Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against
G6PD
Plasmodium vivax
enzymopathy
epidemiology
global health
glucose-6-phosphate dehydrogenase deficiency
malaria
primaquine
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
05 02 2021
05 02 2021
Historique:
received:
25
08
2020
accepted:
03
02
2021
pubmed:
6
2
2021
medline:
3
2
2022
entrez:
5
2
2021
Statut:
epublish
Résumé
X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear. We fitted a Bayesian statistical model to observed G6PD Med allele frequencies in 999 Pashtun patients presenting with acute
Identifiants
pubmed: 33543710
doi: 10.7554/eLife.62448
pii: 62448
pmc: PMC7884069
doi:
pii:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 107548/Z/15/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 093956/Z/10/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107548Z/15/Z
Pays : United Kingdom
Informations de copyright
© 2021, Awab et al.
Déclaration de conflit d'intérêts
GA, FA, NJ, KS, WP, JW, CW, AD, ND, MI, NW No competing interests declared
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