Circulating bioactive sclerostin levels in an Austrian population-based cohort.
Age
Body mass index
Bone mineral density
Bone turnover markers
Gender
Journal
Wiener klinische Wochenschrift
ISSN: 1613-7671
Titre abrégé: Wien Klin Wochenschr
Pays: Austria
ID NLM: 21620870R
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
16
09
2020
accepted:
13
01
2021
pubmed:
6
2
2021
medline:
8
2
2022
entrez:
5
2
2021
Statut:
ppublish
Résumé
Circulating serum sclerostin levels are supposed to give a good estimation of the levels of this negative regulator of bone mass within bone. Most studies evaluating total serum sclerostin found different levels in males compared to females and in older compared to younger subjects. Besides an ELISA detecting total sclerostin an ELISA determining bioactive sclerostin has been developed. The aim of this study was to investigate serum levels of bioactive sclerostin in an Austrian population-based cohort. We conducted a cross-sectional observational study in 235 healthy subjects. Using the bioactive ELISA assay (Biomedica) bioactive sclerostin levels were evaluated. Serum levels of bioactive sclerostin were higher in men than in women (24%). The levels correlated positively with age (r = 0.47). A positive correlation could also be detected with body mass index and bone mineral density. Using the ELISA detecting bioactive sclerostin our results are consistent with data in the literature obtained by different sclerostin assays. The determination of sclerostin concentrations in peripheral blood thus appears to be a robust parameter of bone metabolism.
Sections du résumé
BACKGROUND
BACKGROUND
Circulating serum sclerostin levels are supposed to give a good estimation of the levels of this negative regulator of bone mass within bone. Most studies evaluating total serum sclerostin found different levels in males compared to females and in older compared to younger subjects. Besides an ELISA detecting total sclerostin an ELISA determining bioactive sclerostin has been developed. The aim of this study was to investigate serum levels of bioactive sclerostin in an Austrian population-based cohort.
METHODS
METHODS
We conducted a cross-sectional observational study in 235 healthy subjects. Using the bioactive ELISA assay (Biomedica) bioactive sclerostin levels were evaluated.
RESULTS
RESULTS
Serum levels of bioactive sclerostin were higher in men than in women (24%). The levels correlated positively with age (r = 0.47). A positive correlation could also be detected with body mass index and bone mineral density.
CONCLUSION
CONCLUSIONS
Using the ELISA detecting bioactive sclerostin our results are consistent with data in the literature obtained by different sclerostin assays. The determination of sclerostin concentrations in peripheral blood thus appears to be a robust parameter of bone metabolism.
Identifiants
pubmed: 33544208
doi: 10.1007/s00508-021-01815-0
pii: 10.1007/s00508-021-01815-0
pmc: PMC8813720
doi:
Substances chimiques
Biomarkers
0
Bone Morphogenetic Proteins
0
Genetic Markers
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-44Informations de copyright
© 2021. The Author(s).
Références
Osteoporos Int. 2013 Feb;24(2):489-94
pubmed: 22525978
Exp Gerontol. 2016 Jan;73:49-58
pubmed: 26608808
J Biol Chem. 2005 Jul 22;280(29):26770-5
pubmed: 15908424
J Bone Miner Res. 2011 Jan;26(1):27-34
pubmed: 20499362
Ginekol Pol. 2019;90(7):371-375
pubmed: 31392705
J Bone Miner Res. 2012 Dec;27(12):2592-602
pubmed: 22836717
PLoS One. 2015 Sep 24;10(9):e0138347
pubmed: 26402159
Acta radiol. 1955 Aug;44(2):109-20
pubmed: 13258333
J Clin Endocrinol Metab. 2010 Nov;95(11):5056-62
pubmed: 20631014
J Endocrinol Invest. 2016 Aug;39(8):855-63
pubmed: 26850415
PLoS One. 2017 May 30;12(5):e0178637
pubmed: 28558021
Age (Dordr). 2008 Dec;30(4):273-82
pubmed: 19424851
J Am Geriatr Soc. 2014 Jun;62(6):1023-9
pubmed: 24779429
J Bone Miner Res. 2013 Apr;28(4):855-64
pubmed: 23165952
Gerontology. 2014;60(6):493-501
pubmed: 24943689
Chin Med J (Engl). 2013 Jul;126(13):2480-4
pubmed: 23823821
Wien Klin Wochenschr. 2020 Jan;132(1-2):19-26
pubmed: 31912287
Bone. 2019 Oct;127:612-619
pubmed: 31351195
Front Cell Dev Biol. 2020 Feb 07;8:57
pubmed: 32117983
J Clin Endocrinol Metab. 2014 Apr;99(4):E665-73
pubmed: 24423318
J Bone Miner Metab. 2013 Sep;31(5):579-84
pubmed: 23525828
PLoS One. 2019 Dec 27;14(12):e0227133
pubmed: 31881044
Arch Gynecol Obstet. 2017 Mar;295(3):785-793
pubmed: 28138749
BMC Musculoskelet Disord. 2019 Jun 5;20(1):276
pubmed: 31164134
Bone. 2003 Jun;32(6):681-6
pubmed: 12810175
J Clin Endocrinol Metab. 2012 Jan;97(1):148-54
pubmed: 21994959
J Bone Joint Surg Br. 1958 May;40-B(2):209-18
pubmed: 13539104