A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Prevention.
Coronavirus disease 2019 (COVID-19)
Extracellular vesicles (EVs)
Mesenchymal stem cells (MSCs)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Journal
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
ISSN: 1557-1904
Titre abrégé: J Neuroimmune Pharmacol
Pays: United States
ID NLM: 101256586
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
18
12
2020
accepted:
28
12
2020
pubmed:
6
2
2021
medline:
11
5
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
Extracellular vesicles (EVs) are the common designation for ectosomes, microparticles and microvesicles serving dominant roles in intercellular communication. Both viable and dying cells release EVs to the extracellular environment for transfer of cell, immune and infectious materials. Defined morphologically as lipid bi-layered structures EVs show molecular, biochemical, distribution, and entry mechanisms similar to viruses within cells and tissues. In recent years their functional capacities have been harnessed to deliver biomolecules and drugs and immunological agents to specific cells and organs of interest or disease. Interest in EVs as putative vaccines or drug delivery vehicles are substantial. The vesicles have properties of receptors nanoassembly on their surface. EVs can interact with specific immunocytes that include antigen presenting cells (dendritic cells and other mononuclear phagocytes) to elicit immune responses or affect tissue and cellular homeostasis or disease. Due to potential advantages like biocompatibility, biodegradation and efficient immune activation, EVs have gained attraction for the development of treatment or a vaccine system against the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infection. In this review efforts to use EVs to contain SARS CoV-2 and affect the current viral pandemic are discussed. An emphasis is made on mesenchymal stem cell derived EVs' as a vaccine candidate delivery system.
Identifiants
pubmed: 33544324
doi: 10.1007/s11481-020-09981-0
pii: 10.1007/s11481-020-09981-0
pmc: PMC7862527
doi:
Substances chimiques
Antiviral Agents
0
Immunologic Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
270-288Subventions
Organisme : NIMH NIH HHS
ID : R01 MH115860
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS034239
Pays : United States
Références
Front Microbiol. 2015 Oct 20;6:1132
pubmed: 26539170
Blood. 2012 Jan 19;119(3):756-66
pubmed: 22031862
Nat Rev Drug Discov. 2013 May;12(5):347-57
pubmed: 23584393
Theranostics. 2017 Jan 15;7(3):733-750
pubmed: 28255363
Engineering (Beijing). 2020 Oct;6(10):1153-1161
pubmed: 32292627
Crit Care Med. 2010 Oct;38(10 Suppl):S569-73
pubmed: 21164399
Infect Genet Evol. 2020 Nov;85:104494
pubmed: 32763440
Int J Mol Sci. 2016 Dec 02;17(12):
pubmed: 27918449
Melanoma Res. 2010 Oct;20(5):435-40
pubmed: 20539243
Immunology. 2012 Aug;136(4):385-96
pubmed: 22486354
Open Virol J. 2018 Sep 28;12:134-148
pubmed: 30416610
J Extracell Vesicles. 2018 Aug 07;7(1):1505403
pubmed: 30108686
Front Immunol. 2020 Jun 09;11:1100
pubmed: 32582186
Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L360-L371
pubmed: 29167125
Stem Cell Res Ther. 2018 Jan 29;9(1):17
pubmed: 29378639
Cell Rep. 2018 Oct 16;25(3):715-725.e4
pubmed: 30332650
Trends Genet. 1997 Aug;13(8):335-40
pubmed: 9260521
Vaccines (Basel). 2019 Aug 28;7(3):
pubmed: 31466253
Nat Rev Immunol. 2014 Mar;14(3):195-208
pubmed: 24566916
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
Biophys J. 2009 Nov 4;97(9):2419-28
pubmed: 19883584
Adv Virol. 2009 Jan 1;2009:6239691-6239699
pubmed: 19865606
Curr Opin Immunol. 1995 Jun;7(3):382-8
pubmed: 7546404
Infect Genet Evol. 2020 Nov;85:104422
pubmed: 32544615
J Cell Biol. 2006 Mar 13;172(6):923-35
pubmed: 16533950
Cells. 2019 Dec 11;8(12):
pubmed: 31835680
J Extracell Vesicles. 2014 Aug 04;3:
pubmed: 25143819
J Intern Med. 2007 Nov;262(5):509-25
pubmed: 17949362
Sci Rep. 2017 Nov 10;7(1):15297
pubmed: 29127410
Stem Cells Transl Med. 2015 Nov;4(11):1302-16
pubmed: 26378259
Theranostics. 2017 Jan 1;7(1):81-96
pubmed: 28042318
J Am Soc Nephrol. 2020 Aug;31(8):1683-1687
pubmed: 32371536
Shock. 2015 May;43(5):443-9
pubmed: 25608138
Viruses. 2020 Apr 26;12(5):
pubmed: 32357553
Cancer Gene Ther. 2020 Jun;27(6):395-398
pubmed: 31477807
Blood. 2000 Feb 1;95(3):930-5
pubmed: 10648405
Expert Rev Vaccines. 2007 Oct;6(5):797-808
pubmed: 17931159
Nanomedicine. 2017 Aug;13(6):2061-2065
pubmed: 28365418
J Neuroimmune Pharmacol. 2020 Sep;15(3):443-458
pubmed: 31485884
Blood. 2004 Nov 1;104(9):2761-6
pubmed: 15242875
Semin Cell Dev Biol. 2015 Apr;40:97-104
pubmed: 25704309
ACS Cent Sci. 2020 Mar 25;6(3):315-331
pubmed: 32226821
Methods. 2020 May 1;177:103-113
pubmed: 31917274
J Extracell Vesicles. 2015 Apr 20;4:26316
pubmed: 25899407
Theranostics. 2018 Apr 9;8(10):2709-2721
pubmed: 29774070
Transfus Apher Sci. 2016 Aug;55(1):84-91
pubmed: 27452643
Retrovirology. 2018 Dec 22;15(1):79
pubmed: 30577804
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Toxicol Pathol. 2007 Jun;35(4):495-516
pubmed: 17562483
Methods. 2020 May 1;177:114-125
pubmed: 31790730
Med Mal Infect. 2012 Aug;42(8):335-43
pubmed: 22766273
Am J Respir Crit Care Med. 2018 Jan 1;197(1):104-116
pubmed: 28853608
Biomolecules. 2020 Sep 11;10(9):
pubmed: 32933047
Cells. 2020 Apr 09;9(4):
pubmed: 32283815
Cancer Lett. 2018 Apr 28;420:228-235
pubmed: 29425686
Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):148-156
pubmed: 26928656
Vet Res. 2016 May 31;47(1):59
pubmed: 27246926
Am J Respir Crit Care Med. 2010 Oct 15;182(8):1047-57
pubmed: 20558630
Nat Biotechnol. 2011 Apr;29(4):341-5
pubmed: 21423189
Nano Today. 2015 Jun 1;10(3):397-409
pubmed: 28458718
Nat Rev Microbiol. 2015 Oct;13(10):620-30
pubmed: 26324094
J Immunol. 2011 Jan 1;186(1):73-82
pubmed: 21106852
J Extracell Vesicles. 2020 Aug 6;9(1):1795365
pubmed: 32944185
Sci Adv. 2020 Nov 13;6(46):
pubmed: 33188016
Neoplasia. 2008 Jun;10(6):521-33
pubmed: 18516289
Front Bioeng Biotechnol. 2020 May 26;8:554
pubmed: 32574317
Blood. 2010 Jan 21;115(3):696-705
pubmed: 19903899
Am J Reprod Immunol. 2011 Oct;66(4):259-69
pubmed: 21410811
Int J Mol Sci. 2017 May 24;18(6):
pubmed: 28538671
J Cell Physiol. 2017 Dec;232(12):3552-3564
pubmed: 28112391
J Extracell Vesicles. 2015 Dec 31;4:30087
pubmed: 26725829
Stem Cells Dev. 2020 Jun 15;29(12):747-754
pubmed: 32380908
J Leukoc Biol. 2011 Mar;89(3):329-42
pubmed: 20940323
Cells. 2019 Sep 27;8(10):
pubmed: 31569696
Annu Rev Physiol. 2013;75:593-615
pubmed: 23398155
J Clin Invest. 1998 Jul 1;102(1):136-44
pubmed: 9649567
Medicine (Baltimore). 2020 Jul 31;99(31):e21429
pubmed: 32756149
Blood. 2007 Nov 1;110(9):3234-44
pubmed: 17666571
Front Immunol. 2012 Mar 15;3:46
pubmed: 22566928
J Clin Invest. 2016 Apr 1;126(4):1173-80
pubmed: 27035808
J Immunol. 1999 Oct 15;163(8):4564-73
pubmed: 10510400
Neurotherapeutics. 2016 Jul;13(3):535-46
pubmed: 27324390
PLoS One. 2013 Jul 22;8(7):e69827
pubmed: 23894549
J Control Release. 2017 Nov 28;266:100-108
pubmed: 28919558
Future Oncol. 2012 Oct;8(10):1273-99
pubmed: 23130928
J Tissue Eng Regen Med. 2019 Sep;13(9):1738-1755
pubmed: 31216380
Adv Exp Med Biol. 2011;716:186-211
pubmed: 21713658
Nat Rev Microbiol. 2017 Sep;15(9):559-572
pubmed: 28649136
Stem Cells. 2010 Dec;28(12):2229-38
pubmed: 20945332
J Biomol Struct Dyn. 2021 Sep;39(15):5831-5842
pubmed: 32643586
Curr Opin Genet Dev. 2000 Dec;10(6):651-5
pubmed: 11088016
Kidney Blood Press Res. 2020;45(5):661-670
pubmed: 32957112
Br J Cancer. 1999 Jul;80(9):1312-21
pubmed: 10424731
Commun Integr Biol. 2010 Sep;3(5):447-50
pubmed: 21057637
Nat Rev Drug Discov. 2020 May;19(5):305-306
pubmed: 32273591
PLoS One. 2011 Apr 14;6(4):e18564
pubmed: 21533172
Nature. 2015 Nov 19;527(7578):329-35
pubmed: 26524530
J Cell Biol. 2013 Feb 18;200(4):373-83
pubmed: 23420871
J Infect. 2020 May;80(5):e14-e17
pubmed: 32171867
J Med Virol. 2020 Nov;92(11):2286-2287
pubmed: 32347980
Front Physiol. 2020 Jan 14;10:1569
pubmed: 32009978
Int J Mol Med. 2017 Sep;40(3):834-844
pubmed: 28737826
ACS Nano. 2020 Oct 27;14(10):12522-12537
pubmed: 33034449
Bone Res. 2020 Jun 19;8:25
pubmed: 32596023
Crit Care Med. 2005 Nov;33(11):2540-6
pubmed: 16276178
Acc Chem Res. 2019 Jul 16;52(7):1761-1770
pubmed: 31181910
Anal Bioanal Chem. 2018 Jun;410(16):3805-3814
pubmed: 29671027
Int J Mol Sci. 2019 Mar 27;20(7):
pubmed: 30934732
Front Biosci. 2008 May 01;13:3415-22
pubmed: 18508443
Sci Rep. 2019 Sep 10;9(1):13012
pubmed: 31506601
Cell Mol Life Sci. 2019 Jun;76(12):2369-2382
pubmed: 30891621
Vaccine. 2011 Aug 5;29(34):5705-10
pubmed: 21679737
FASEB J. 2018 Aug;32(8):4241-4246
pubmed: 29505299
Thromb Res. 2014 Mar;133(3):507-14
pubmed: 24423888
Aging Dis. 2020 Mar 9;11(2):216-228
pubmed: 32257537
Clin Infect Dis. 2020 Nov 19;71(16):2230-2232
pubmed: 32266381
J Trauma Acute Care Surg. 2019 Jul;87(1S Suppl 1):S74-S82
pubmed: 31246910
Cancer Lett. 2009 Oct 8;283(2):168-75
pubmed: 19401262
Matter. 2020 Jul 1;3(1):287-301
pubmed: 32835220
Wiley Interdiscip Rev RNA. 2017 Jul;8(4):
pubmed: 28130830
J Clin Invest. 2016 Apr 1;126(4):1139-43
pubmed: 27035805
Cell Host Microbe. 2012 Oct 18;12(4):558-70
pubmed: 23084922
Cancer Sci. 2017 May;108(5):824-830
pubmed: 28256033
J Neurooncol. 2013 May;113(1):1-11
pubmed: 23456661
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Disaster Med Public Health Prep. 2021 Apr;15(2):e29-e31
pubmed: 32576315
Biotechnol J. 2018 Apr;13(4):e1700443
pubmed: 29274250
Stem Cells Int. 2020 Sep 24;2020:8835986
pubmed: 33014070
J Virol. 2009 Jan;83(2):512-21
pubmed: 18987139
J Immunol Methods. 2008 Sep 30;338(1-2):21-30
pubmed: 18675270
Mol Ther. 2018 Dec 5;26(12):2838-2847
pubmed: 30341012
Nat Nanotechnol. 2020 Aug;15(8):630-645
pubmed: 32661375
Cytotherapy. 2020 Sep;22(9):482-485
pubmed: 32425691
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17380-5
pubmed: 24101524
Nano Lett. 2015 Jan 14;15(1):266-74
pubmed: 25506626
Biochem Genet. 1972 Dec;7(3):253-8
pubmed: 4646764
J Clin Invest. 2016 Apr 1;126(4):1181-9
pubmed: 27035809
J Transl Med. 2018 Jan 9;16(1):1
pubmed: 29316942
Arch Pharm Res. 2012 Feb;35(2):213-21
pubmed: 22370776
Sci Rep. 2015 Aug 19;5:13243
pubmed: 26285688
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6328-33
pubmed: 20304794
Sci Rep. 2018 Jan 19;8(1):1171
pubmed: 29352188
Respir Res. 2018 Nov 9;19(1):218
pubmed: 30413158
Kidney Int. 2020 Jul;98(1):219-227
pubmed: 32327202
J Extracell Vesicles. 2014 Dec 22;3:25465
pubmed: 25536933
Science. 2020 May 29;368(6494):948-950
pubmed: 32393526
J Clin Pathol. 2021 Feb;74(2):76-83
pubmed: 32817204
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E894-901
pubmed: 26831114
Front Microbiol. 2017 Jun 09;8:1053
pubmed: 28649237
J Extracell Vesicles. 2015 May 14;4:27066
pubmed: 25979354
Nat Biomed Eng. 2018 Nov;2(11):831-840
pubmed: 31015615
Sci Rep. 2016 Nov 16;6:37242
pubmed: 27849050
Cytometry A. 2013 Feb;83(2):242-50
pubmed: 23125136
Exp Mol Med. 2018 Apr 13;50(4):1-12
pubmed: 29650962
Cell Death Dis. 2020 Jul 27;11(7):584
pubmed: 32719324
Clin Sci (Lond). 2013 Jul 1;125(2):77-85
pubmed: 23379624
Autoimmun Rev. 2020 Jul;19(7):102554
pubmed: 32380316
Stem Cell Res Ther. 2017 Feb 16;8(1):38
pubmed: 28209182
Methods Mol Biol. 2015;1295:179-209
pubmed: 25820723
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4991-6
pubmed: 25368198
Clin Biochem. 2014 Jan;47(1-2):135-8
pubmed: 24183884
Drug Deliv. 2020 Dec;27(1):585-598
pubmed: 32264719
Nat Rev Immunol. 2009 Aug;9(8):581-93
pubmed: 19498381
Am J Pathol. 2007 Apr;170(4):1136-47
pubmed: 17392154
EMBO J. 2020 Aug 17;39(16):e105057
pubmed: 32643835
Cell Host Microbe. 2013 Sep 11;14(3):232-41
pubmed: 24034610
Oxid Med Cell Longev. 2020 Jan 18;2020:4213541
pubmed: 32051731
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
J Immunol Res. 2016;2016:3623898
pubmed: 27066504
PLoS Pathog. 2019 Feb 4;15(2):e1007536
pubmed: 30716130
Curr Biol. 1999 Aug 26;9(16):861-8
pubmed: 10469592
Infect Immun. 2010 Dec;78(12):5116-25
pubmed: 20837713
Cancer Gene Ther. 2017 Feb;24(2):48-56
pubmed: 27982021
PLoS One. 2008 Jun 18;3(6):e2461
pubmed: 18560543
J Biomol Struct Dyn. 2021 May;39(8):3034-3060
pubmed: 32351170
Stem Cell Res Ther. 2020 Aug 18;11(1):361
pubmed: 32811531
Biology (Basel). 2020 Jan 20;9(1):
pubmed: 31968627
Nanomaterials (Basel). 2020 Sep 15;10(9):
pubmed: 32942556
Stem Cells Transl Med. 2015 Dec;4(12):1500-10
pubmed: 26494779
J Control Release. 2020 Sep 10;325:135-140
pubmed: 32622963
Int J Mol Sci. 2019 Aug 30;20(17):
pubmed: 31480219
Hum Vaccin Immunother. 2012 Feb;8(2):174-83
pubmed: 22426368
J Extracell Vesicles. 2018 Nov 30;7(1):1541396
pubmed: 30533204
Virology. 2007 May 25;362(1):26-37
pubmed: 17258782
PLoS Biol. 2013 Jul;11(7):e1001604
pubmed: 23874151
J Biol Chem. 2014 Aug 8;289(32):22258-67
pubmed: 24951588
Drug Discov Today. 2020 Jul;25(7):1124-1125
pubmed: 32387262
Int J Mol Sci. 2019 Sep 21;20(19):
pubmed: 31546622
Traffic. 2010 May;11(5):675-87
pubmed: 20136776
Cold Spring Harb Protoc. 2015 Apr 01;2015(4):319-23
pubmed: 25834266
PLoS Pathog. 2017 Aug 24;13(8):e1006524
pubmed: 28837697
Cell Mol Neurobiol. 2016 Apr;36(3):301-12
pubmed: 27053351
ScientificWorldJournal. 2015;2015:657086
pubmed: 25695100
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
J Cell Mol Med. 2006 Apr-Jun;10(2):364-75
pubmed: 16796805
Curr Environ Health Rep. 2019 Sep;6(3):73-79
pubmed: 31102182
J Clin Med. 2018 Oct 14;7(10):
pubmed: 30322213
Trends Parasitol. 2012 Aug;28(8):311-9
pubmed: 22727810
AIDS Res Hum Retroviruses. 2011 Feb;27(2):167-78
pubmed: 20964480
JAMA. 2020 May 12;323(18):1843-1844
pubmed: 32159775
Thorax. 2012 Jun;67(6):533-9
pubmed: 22250097
EMBO Rep. 2015 Jan;16(1):24-43
pubmed: 25488940
Front Immunol. 2018 Apr 12;9:723
pubmed: 29706960
J Thromb Haemost. 2016 May;14(5):1031-42
pubmed: 26857798
J Extracell Vesicles. 2015 Jul 17;4:27031
pubmed: 26194179
Anal Chem. 2018 Jul 3;90(13):8011-8019
pubmed: 29806448
Colloids Surf B Biointerfaces. 2017 Nov 1;159:62-77
pubmed: 28780462
Nanomedicine. 2015 May;11(4):879-83
pubmed: 25659648
Biochem J. 1991 Mar 1;274 ( Pt 2):381-6
pubmed: 1848755
Med Res Rev. 2014 Sep;34(5):1100-26
pubmed: 24866817
Int J Mol Sci. 2017 Mar 20;18(3):
pubmed: 28335522
Annu Rev Immunol. 2018 Apr 26;36:435-459
pubmed: 29400984
Chin Med J (Engl). 2020 May 5;133(9):1039-1043
pubmed: 32118639
AIDS Res Hum Retroviruses. 2010 Feb;26(2):173-92
pubmed: 20156100
J Extracell Vesicles. 2016 Oct 31;5:32945
pubmed: 27802845
J Neuroimmune Pharmacol. 2020 Sep;15(3):359-386
pubmed: 32696264
Trends Mol Med. 2018 Mar;24(3):242-256
pubmed: 29449149
Stem Cells Int. 2016;2016:7653489
pubmed: 26770213
Cells. 2020 Apr 16;9(4):
pubmed: 32316248
Histopathology. 2020 Nov;77(5):823-831
pubmed: 32374419
Cytogenet Genome Res. 2004;105(2-4):351-62
pubmed: 15237223
J Immunol. 2012 Jul 15;189(2):744-54
pubmed: 22711894
Front Immunol. 2011 Nov 29;2:67
pubmed: 22566856
PLoS One. 2017 Jan 23;12(1):e0170628
pubmed: 28114422
Signal Transduct Target Ther. 2020 Sep 15;5(1):203
pubmed: 32934211
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017 Aug;60(8):826-829
pubmed: 28677049