Dose-dependent beneficial effects of citrulline supplementation in short bowel syndrome in rats.

Animals Citrulline Dietary Supplements Ileum Intestinal Mucosa Intestine, Small Rats Short Bowel Syndrome / drug therapy
Citrulline Muscle Nutrition Protein synthesis mTOR

Journal

Nutrition (Burbank, Los Angeles County, Calif.)
ISSN: 1873-1244
Titre abrégé: Nutrition
Pays: United States
ID NLM: 8802712

Informations de publication

Date de publication:
05 2021
Historique:
received: 13 08 2020
revised: 04 12 2020
accepted: 07 12 2020
pubmed: 6 2 2021
medline: 24 6 2021
entrez: 5 2 2021
Statut: ppublish

Résumé

Supplementing diet with citrulline has proved an efficient means of preserving nitrogen balance and improving nutritional status after massive intestinal resection. The aim of this study was to model the action of citrulline in gut-resected rats using a dose-ranging study focused on skeletal muscle nitrogen homeostasis. Forty-six rats were randomly assigned to one of the following groups: citrulline 0.5 g·kg·d There was a significant dose-dependent association between rat weight and citrulline dose up to 2.5 g·kg·d Citrulline promotes body weight gain, preserves muscle trophicity, and enhances intestinal adaptation in a dose-dependent manner in a model of resected rats.

Identifiants

DOI: 10.1016/j.nut.2020.111118 PMID: 33545544
pubmed: 33545544
pii: S0899-9007(20)30401-9
doi: 10.1016/j.nut.2020.111118
pii:
doi:

Substances chimiques

Citrulline 29VT07BGDA

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

111118

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Jerome Filippi (J)

Laboratoire de Biologie de la Nutrition, Faculté de Pharmacie, Université Paris-Descartes, Paris, France; Département de Gastroentérologie et Nutrition, Hôpital L'Archet, Nice, France.

Amandine Rubio (A)

Université Grenoble Alpes, Laboratoire Bioénergétique Fondamental et Appliqué, Grenoble, France; Département de Pédiatrie, Hôpital Couple Enfant, CHU Grenoble Alpes, Grenoble, France.

Virgine Lasserre (V)

Laboratoire de Biomathématiques, Faculté de Pharmacie, Université Paris-Descartes, Paris, France.

Jean Maccario (J)

Laboratoire de Biomathématiques, Faculté de Pharmacie, Université Paris-Descartes, Paris, France.

Stephanie Walrand (S)

Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France; Service de Biochimie, Hôtel-Dieu Cochin, APHP, Paris, France.

Nathalie Neveux (N)

Laboratoire de Biologie de la Nutrition, Faculté de Pharmacie, Université Paris-Descartes, Paris, France; Service de Biochimie, Hôtel-Dieu Cochin, APHP, Paris, France.

Servane Le Plénier (SL)

Laboratoire de Biologie de la Nutrition, Faculté de Pharmacie, Université Paris-Descartes, Paris, France.

Xavier Hébuterne (X)

Département de Gastroentérologie et Nutrition, Hôpital L'Archet, Nice, France.

Luc Cynober (L)

Laboratoire de Biologie de la Nutrition, Faculté de Pharmacie, Université Paris-Descartes, Paris, France; Service de Biochimie, Hôtel-Dieu Cochin, APHP, Paris, France.

Christophe Moinard (C)

Laboratoire de Biologie de la Nutrition, Faculté de Pharmacie, Université Paris-Descartes, Paris, France; Université Grenoble Alpes, Laboratoire Bioénergétique Fondamental et Appliqué, Grenoble, France. Electronic address: christophe.moinard@univ-grenoble-alpes.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dose-dependent beneficial effects of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés diaminés › Citrulline › Dose-dependent beneficial effects of...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Dose-dependent beneficial effects of...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Iléum › Dose-dependent beneficial effects of...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Dose-dependent beneficial effects of...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Intestin grêle › Dose-dependent beneficial effects of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Dose-dependent beneficial effects of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Syndrome de l'intestin court › Dose-dependent beneficial effects of...