An aging and p53 related marker:
DNA methylation
HOXA5
ageing
gene expression
p53
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
05 02 2021
05 02 2021
Historique:
received:
10
09
2020
accepted:
04
01
2021
pubmed:
7
2
2021
medline:
23
7
2021
entrez:
6
2
2021
Statut:
ppublish
Résumé
The process of aging has been associated with differential patterns of DNA methylation which relate to changes in gene expression. Hence, we aimed to identify genes with significant age-related methylation differences and to study their mRNA and protein expression profile. Genome-wide DNA methylation analysis was performed with the Illumina Infinium Methylation EPIC BeadChip Microarray on bisulfite-converted DNA prepared from monocytes derived from young (average age: 23.8 yrs) and old (average age: 81.5 yrs) volunteers that are separated by at least 50 years of age difference, n=4, respectively. Differentially methylated CpG sites were assigned to the associated genes and validated by deep sequencing analysis (n=20). Demonstrating an age-associated significant increase of methylation in the promoter region (p=1x10
Identifiants
pubmed: 33547267
pii: 202621
doi: 10.18632/aging.202621
pmc: PMC7950283
doi:
Substances chimiques
HOXA5 protein, human
0
Homeodomain Proteins
0
RNA, Messenger
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4831-4849Références
Epigenetics. 2006 Jul-Sep;1(3):127-30
pubmed: 17965610
Aging (Albany NY). 2018 Apr 18;10(4):573-591
pubmed: 29676998
Nature. 2000 Jun 22;405(6789):974-8
pubmed: 10879542
BMC Bioinformatics. 2017 Apr 14;18(1):216
pubmed: 28410574
Mol Cell. 2001 Aug;8(2):317-25
pubmed: 11545734
Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):900-5
pubmed: 8570656
Nat Cell Biol. 2013 Dec;15(12):1495-506
pubmed: 24270890
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10522-7
pubmed: 22689993
J Biol Chem. 1987 Feb 5;262(4):1740-7
pubmed: 3805051
Nat Biotechnol. 2013 Dec;31(12):1137-42
pubmed: 24108092
J Infect Dis. 2015 Nov 15;212(10):1563-73
pubmed: 25969563
Mol Carcinog. 2009 Dec;48(12):1109-15
pubmed: 19554572
PLoS One. 2013 Apr 24;8(4):e61946
pubmed: 23637934
Biochem J. 2009 Mar 15;418(3):475-89
pubmed: 19228121
Clin Cancer Res. 2007 Sep 1;13(17):5048-55
pubmed: 17785556
Histol Histopathol. 2008 Sep;23(9):1143-9
pubmed: 18581285
Aging (Albany NY). 2017 Apr;9(4):1143-1152
pubmed: 28377537
Front Oncol. 2019 May 21;9:394
pubmed: 31165042
Aging Cell. 2012 Apr;11(2):181-6
pubmed: 22321768
BMC Med Genomics. 2020 Jan 8;13(1):6
pubmed: 31914996
Science. 2002 Nov 1;298(5595):1039-43
pubmed: 12351676
Database (Oxford). 2016 Apr 05;2016:
pubmed: 27048349
Leuk Lymphoma. 2016 May;57(5):1201-4
pubmed: 26437212
Epigenomics. 2016 Mar;8(3):389-99
pubmed: 26673039
Nat Rev Mol Cell Biol. 2015 Oct;16(10):593-610
pubmed: 26373265
Oncogene. 2011 Mar 24;30(12):1390-401
pubmed: 21132003
Epigenetics. 2013 Jul;8(7):765-71
pubmed: 23803588
Pathol Int. 2010 Oct;60(10):661-6
pubmed: 20846263
PLoS One. 2013 Jun 27;8(6):e67378
pubmed: 23826282
Mol Cell. 2013 Jan 24;49(2):359-367
pubmed: 23177740
PLoS One. 2009 Jun 09;4(6):e5846
pubmed: 19513108
Sci Adv. 2016 Jul 29;2(7):e1600584
pubmed: 27482540
Biogerontology. 2014 Aug;15(4):317-28
pubmed: 24770842
Genome Biol. 2014 Feb 03;15(2):R24
pubmed: 24490752
Nature. 2005 Aug 4;436(7051):725-30
pubmed: 16079851
Dev Cell. 2010 Nov 16;19(5):698-711
pubmed: 21074720
Mutat Res. 2008 Dec 1;647(1-2):30-8
pubmed: 18778722
Lymphat Res Biol. 2005;3(4):240-52
pubmed: 16379594
Nature. 2012 Sep 6;489(7414):57-74
pubmed: 22955616
Aging (Albany NY). 2017 Feb 14;9(2):419-446
pubmed: 28198702
Neuropsychopharmacology. 2013 Jan;38(1):23-38
pubmed: 22781841
Cell. 2016 Dec 15;167(7):1719-1733.e12
pubmed: 27984723
World J Gastroenterol. 2011 Aug 7;17(29):3407-19
pubmed: 21876633
Clin Epigenetics. 2016 Nov 21;8:122
pubmed: 27895806
Mol Carcinog. 2004 Sep;41(1):54-66
pubmed: 15352125
Cell Adh Migr. 2007 Oct-Dec;1(4):185-95
pubmed: 19262140
Physiol Genomics. 2010 Apr 1;41(2):194-200
pubmed: 20145203
Cancer Res. 2016 Jun 15;76(12):3446-50
pubmed: 27256564
Aging Cell. 2010 Feb;9(1):54-63
pubmed: 19895632
Mamm Genome. 2009 Sep-Oct;20(9-10):674-80
pubmed: 19777308
J Cell Physiol. 2001 Aug;188(2):161-9
pubmed: 11424082
Breast Cancer Res Treat. 2017 Jul;164(1):209-219
pubmed: 28364215
Mol Cell. 2006 Aug;23(4):575-87
pubmed: 16916644
Sci Adv. 2017 Nov 17;3(11):eaao1799
pubmed: 29159284
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Cell Rep. 2012 Nov 29;2(5):1151-8
pubmed: 23177625
Nat Methods. 2014 Nov;11(11):1138-1140
pubmed: 25262207
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W551-6
pubmed: 21565797
Cancer Cell. 2003 Feb;3(2):117-30
pubmed: 12620407
Nucleic Acids Res. 2008 Nov;36(19):e122
pubmed: 18753151
Gene. 2019 Mar 20;689:18-23
pubmed: 30521886
FASEB J. 2014 Jul;28(7):3261-72
pubmed: 24858281
Aging (Albany NY). 2018 Jul 26;10(7):1758-1775
pubmed: 30048243
Aging (Albany NY). 2015 Dec;7(12):1159-70
pubmed: 26678252
Genome Biol. 2013;14(10):R115
pubmed: 24138928
Epigenetics. 2014 Aug;9(8):1061-70
pubmed: 24802768
Blood. 2009 Feb 5;113(6):1315-25
pubmed: 18832655
Genome Biol. 2019 Mar 14;20(1):55
pubmed: 30871603
Cancer Immunol Immunother. 2009 Dec;58(12):1909-17
pubmed: 19139887
Epigenetics. 2016 Apr 2;11(4):247-58
pubmed: 26890304
J Cancer. 2017 Apr 9;8(6):1071-1081
pubmed: 28529621