A Review on Potential Footprints of Ferulic Acid for Treatment of Neurological Disorders.
Alzheimer’s disease
Depression
Epilepsy
Ferulic acid
Ischemia‐reperfusion injury
Parkinson’s disease
Journal
Neurochemical research
ISSN: 1573-6903
Titre abrégé: Neurochem Res
Pays: United States
ID NLM: 7613461
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
20
07
2020
accepted:
22
01
2021
revised:
16
01
2021
pubmed:
7
2
2021
medline:
28
9
2021
entrez:
6
2
2021
Statut:
ppublish
Résumé
Ferulic acid is being screened in preclinical settings to combat various neurological disorders. It is a naturally occurring dietary flavonoid commonly found in grains, fruits, and vegetables such as rice, wheat, oats, tomatoes, sweet corn etc., which exhibits protective effects against a number of neurological diseases such as epilepsy, depression, ischemia-reperfusion injury, Alzheimer's disease, and Parkinson's disease. Ferulic acid prevents and treats different neurological diseases pertaining to its potent anti-oxidative and anti-inflammatory effects, beside modulating unique neuro-signaling pathways. It stays in the bloodstream for longer periods than other dietary polyphenols and antioxidants and easily crosses blood brain barrier. The use of novel drug delivery systems such as solid-lipid nanoparticles (SLNs) or its salt forms (sodium ferulate, ethyl ferulate, and isopentyl ferulate) further enhance its bioavailability and cerebral penetration. Based on reported studies, ferulic acid appears to be a promising molecule for treatment of neurological disorders; however, more preclinical (in vitro and in vivo) mechanism-based studies should be planned and conceived followed by its testing in clinical settings.
Identifiants
pubmed: 33547615
doi: 10.1007/s11064-021-03257-6
pii: 10.1007/s11064-021-03257-6
doi:
Substances chimiques
Coumaric Acids
0
Nerve Tissue Proteins
0
Neuroprotective Agents
0
ferulic acid
AVM951ZWST
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1043-1057Références
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