Thyroid function, sex hormones and sexual function: a Mendelian randomization study.
Adult
Erectile Dysfunction
/ etiology
Estradiol
/ blood
Female
Gonadal Steroid Hormones
Humans
Hyperthyroidism
/ complications
Hypothyroidism
/ complications
Male
Mendelian Randomization Analysis
/ methods
Middle Aged
Sex Hormone-Binding Globulin
/ metabolism
Sexual Dysfunction, Physiological
/ etiology
Sexual Dysfunctions, Psychological
/ etiology
Testosterone
Thyroid Gland
/ physiology
Thyrotropin
/ blood
Thyroxine
/ blood
Erectile dysfunction
Mendelian randomization
Reproductive lifespan
SHBG
Testosterone
Thyroid function
Journal
European journal of epidemiology
ISSN: 1573-7284
Titre abrégé: Eur J Epidemiol
Pays: Netherlands
ID NLM: 8508062
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
07
10
2020
accepted:
20
01
2021
pubmed:
7
2
2021
medline:
12
6
2021
entrez:
6
2
2021
Statut:
ppublish
Résumé
Hypothyroidism and hyperthyroidism are observationally associated with sex hormone concentrations and sexual dysfunction, but causality is unclear. We investigated whether TSH, fT4, hypo- and hyperthyroidism are causally associated with sex hormones and sexual function. We used publicly available summary statistics from genome-wide association studies on TSH and fT4 and hypo- and hyperthyroidism from the ThyroidOmics Consortium (N ≤ 54,288). Outcomes from UK Biobank (women ≤ 194,174/men ≤ 167,020) and ReproGen (women ≤ 252,514) were sex hormones (sex hormone binding globulin [SHBG], testosterone, estradiol, free androgen index [FAI]) and sexual function (ovulatory function in women: duration of menstrual period, age at menarche and menopause, reproductive lifespan, and erectile dysfunction in men). We performed two-sample Mendelian randomization (MR) analyses on summary level, and unweighted genetic risk score (GRS) analysis on individual level data. One SD increase in TSH was associated with a 1.332 nmol/L lower (95% CI: - 0.717,- 1.946; p = 2 × 10
Identifiants
pubmed: 33548002
doi: 10.1007/s10654-021-00721-z
pii: 10.1007/s10654-021-00721-z
pmc: PMC7612952
mid: EMS146271
doi:
Substances chimiques
Gonadal Steroid Hormones
0
Sex Hormone-Binding Globulin
0
Testosterone
3XMK78S47O
Estradiol
4TI98Z838E
Thyrotropin
9002-71-5
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
335-344Subventions
Organisme : Wellcome Trust
ID : 204623
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204623/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00002/7
Pays : United Kingdom
Références
Stat Med. 2017 May 20;36(11):1783-1802
pubmed: 28114746
J Reprod Immunol. 2011 Jun;90(1):58-66
pubmed: 21641659
Int J Epidemiol. 2016 Dec 1;45(6):1717-1726
pubmed: 28338968
Lancet. 2012 Mar 24;379(9821):1142-54
pubmed: 22273398
Front Immunol. 2018 Oct 04;9:2279
pubmed: 30337927
PLoS Genet. 2014 Feb 27;10(2):e1004123
pubmed: 24586183
Nat Commun. 2018 Oct 26;9(1):4455
pubmed: 30367059
Nat Genet. 2016 Jul;48(7):709-17
pubmed: 27182965
Nat Genet. 2018 May;50(5):693-698
pubmed: 29686387
J Endocrinol Invest. 2019 May;42(5):567-576
pubmed: 30284222
Stat Med. 2008 Apr 15;27(8):1133-63
pubmed: 17886233
Hormones (Athens). 2019 Dec;18(4):365-381
pubmed: 31734887
Eur J Endocrinol. 2009 Jun;160(6):985-91
pubmed: 19273570
N Engl J Med. 2001 Jun 7;344(23):1743-9
pubmed: 11396440
Eur J Epidemiol. 2018 Oct;33(10):947-952
pubmed: 30039250
Horm Mol Biol Clin Investig. 2019 Mar 9;38(1):
pubmed: 30851158
J Mol Endocrinol. 2009 Jul;43(1):19-27
pubmed: 19336534
Genet Epidemiol. 2016 May;40(4):304-14
pubmed: 27061298
Endocrine. 2017 Dec;58(3):397-407
pubmed: 28429281
Clin Endocrinol (Oxf). 1990 Mar;32(3):301-6
pubmed: 2344696
Biol Reprod. 2018 Nov 1;99(5):907-921
pubmed: 29767691
Sex Med Rev. 2019 Jan;7(1):57-70
pubmed: 30057137
Sex Med Rev. 2020 Apr;8(2):217-230
pubmed: 30458985
Int J Epidemiol. 2016 Dec 1;45(6):1961-1974
pubmed: 27616674
Fertil Steril. 1987 Aug;48(2):318-20
pubmed: 3111894
J Steroid Biochem Mol Biol. 2019 Jun;190:207-211
pubmed: 30970279
Thyroid. 2014 Nov;24(11):1642-9
pubmed: 25087688
Hum Mol Genet. 2018 Aug 1;27(R2):R195-R208
pubmed: 29771313
Stat Med. 2015 Sep 20;34(21):2926-40
pubmed: 25950993
Mol Cell Endocrinol. 2018 May 15;467:49-59
pubmed: 29175529
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120