Predictive Value of Cardiopulmonary Exercise Testing Parameters in Ambulatory Advanced Heart Failure.
ambulatory heart failure
cardiac transplant
cardiopulmonary exercise stress test
mechanical circulatory support
predictors
Journal
JACC. Heart failure
ISSN: 2213-1787
Titre abrégé: JACC Heart Fail
Pays: United States
ID NLM: 101598241
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
10
08
2020
revised:
03
11
2020
accepted:
12
11
2020
pubmed:
8
2
2021
medline:
25
2
2023
entrez:
7
2
2021
Statut:
ppublish
Résumé
This study sought to determine cardiopulmonary exercise (CPX) predictors of the combined outcome of durable mechanical circulatory support (MCS), transplantation, or death at 1 year among patients with ambulatory advanced heart failure (HF). Optimal CPX predictors of outcomes in contemporary ambulatory advanced HF patients are unclear. REVIVAL (Registry Evaluation of Vital Information for ventricular assist devices [VADs] in Ambulatory Life) enrolled 400 systolic HF patients, INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) profiles 4-7. CPX was performed by 273 subjects 2 ± 1 months after study enrollment. Discriminative power of maximal (peak oxygen consumption [peak VO At 1 year, there were 39 events (6 transplants, 15 deaths, 18 MCS implantations). Peak VO Among patients with ambulatory advanced HF, the strongest maximal and submaximal CPX predictor of MCS implantation, transplantation, or death at 1 year were CP and VE/VCO
Sections du résumé
OBJECTIVES
This study sought to determine cardiopulmonary exercise (CPX) predictors of the combined outcome of durable mechanical circulatory support (MCS), transplantation, or death at 1 year among patients with ambulatory advanced heart failure (HF).
BACKGROUND
Optimal CPX predictors of outcomes in contemporary ambulatory advanced HF patients are unclear.
METHODS
REVIVAL (Registry Evaluation of Vital Information for ventricular assist devices [VADs] in Ambulatory Life) enrolled 400 systolic HF patients, INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) profiles 4-7. CPX was performed by 273 subjects 2 ± 1 months after study enrollment. Discriminative power of maximal (peak oxygen consumption [peak VO
RESULTS
At 1 year, there were 39 events (6 transplants, 15 deaths, 18 MCS implantations). Peak VO
CONCLUSIONS
Among patients with ambulatory advanced HF, the strongest maximal and submaximal CPX predictor of MCS implantation, transplantation, or death at 1 year were CP and VE/VCO
Identifiants
pubmed: 33549559
pii: S2213-1779(20)30703-4
doi: 10.1016/j.jchf.2020.11.008
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT01369407']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
226-236Subventions
Organisme : NHLBI NIH HHS
ID : HHSN268201100026C
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002240
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132154
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Funding support and Author Disclosures Supported by U.S. National Institutes of Health, National Heart, Lung, and Blood Institute (NHLBI) contract HHSN268201100026C, and National Center for Advancing Translational Sciences grant UL1TR002240. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, or the US Department of Health and Human Services. Dr. Lanfear has received research grants from NHLBI (R01HL132154), Amgen, Bayer, and Janssen; and is a consultant for Amgen, Janssen, Ortho Diagnostics, and Novartis. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.