Acute acral eruptions in children during the COVID-19 pandemic: Characteristics of 103 children and their family clusters.
Adolescent
Antibodies, Antinuclear
/ blood
COVID-19
/ complications
Chilblains
/ pathology
Child
Erythema
/ pathology
Family
Female
Hidradenitis
/ pathology
Humans
Immunoglobulin G
/ blood
Lymphocytes
/ pathology
Male
Mucinoses
/ pathology
Pandemics
Retrospective Studies
Skin
/ pathology
Vasculitis
/ pathology
Acral erythema
COVID-19
Chilblains
Children
Familial transmission.
Journal
Annales de dermatologie et de venereologie
ISSN: 0151-9638
Titre abrégé: Ann Dermatol Venereol
Pays: France
ID NLM: 7702013
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
21
07
2020
revised:
15
10
2020
accepted:
26
11
2020
pubmed:
9
2
2021
medline:
18
5
2021
entrez:
8
2
2021
Statut:
ppublish
Résumé
A marked increase in frequency of acute acral eruptions (AAE) was observed in children during the COVID-19 pandemic in the spring period. In this observational multicenter study, based on children with AAE, we aimed to assess the proportion of household members possibly infected by SARS-CoV-2. We collected data from all children observed with AAE, prospectively from April 7, 2020 to June 22, 2020, and retrospectively since February 28, 2020. The primary outcome was the household infection rate, defined as the proportion of family clusters having at least one member with COVID-19 infection other than the child with AAE ("index child"). The definition of a case was based on characteristic clinical signs and a positive PCR or serology. The study included 103 children in 10 French departments and in Quebec. The median age was 13 years and the interquartile range [8-15], with a female-to-male ratio of 1/1.15. In children with AAE, all PCR tests were negative (n=18), and serology was positive in 2/14 (14.3%) cases. We found no significant anomalies in the lab results. A total of 66 of the 103 families (64.1%) of included children had at least one other infected member apart from the index child. The total number of household members was 292, of whom 119 (40.8%) were considered possibly infected by SARS-CoV-2. No index children or households exhibited severe COVID-19. Among the 103 households included, 64.1% had at least one infected member. Neither children with AAE nor their households showed severe COVID-19.
Sections du résumé
BACKGROUND
BACKGROUND
A marked increase in frequency of acute acral eruptions (AAE) was observed in children during the COVID-19 pandemic in the spring period.
OBJECTIVES
OBJECTIVE
In this observational multicenter study, based on children with AAE, we aimed to assess the proportion of household members possibly infected by SARS-CoV-2.
METHODS
METHODS
We collected data from all children observed with AAE, prospectively from April 7, 2020 to June 22, 2020, and retrospectively since February 28, 2020. The primary outcome was the household infection rate, defined as the proportion of family clusters having at least one member with COVID-19 infection other than the child with AAE ("index child"). The definition of a case was based on characteristic clinical signs and a positive PCR or serology.
RESULTS
RESULTS
The study included 103 children in 10 French departments and in Quebec. The median age was 13 years and the interquartile range [8-15], with a female-to-male ratio of 1/1.15. In children with AAE, all PCR tests were negative (n=18), and serology was positive in 2/14 (14.3%) cases. We found no significant anomalies in the lab results. A total of 66 of the 103 families (64.1%) of included children had at least one other infected member apart from the index child. The total number of household members was 292, of whom 119 (40.8%) were considered possibly infected by SARS-CoV-2. No index children or households exhibited severe COVID-19.
DISCUSSION
CONCLUSIONS
Among the 103 households included, 64.1% had at least one infected member. Neither children with AAE nor their households showed severe COVID-19.
Identifiants
pubmed: 33551211
pii: S0151-9638(21)00005-3
doi: 10.1016/j.annder.2020.11.005
pmc: PMC7831537
pii:
doi:
Substances chimiques
Antibodies, Antinuclear
0
Immunoglobulin G
0
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
94-100Informations de copyright
Copyright © 2021. Published by Elsevier Masson SAS.
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