Sex-Specific Effects of Myo-Inositol Ingested During Lactation in the Improvement of Metabolic Health in Adult Rats.
Adipose Tissue, White
/ drug effects
Animals
Body Weight
/ drug effects
Caloric Restriction
Dietary Supplements
Eating
Energy Metabolism
/ drug effects
Female
Gene Expression Regulation
/ drug effects
Inositol
/ pharmacology
Insulin Resistance
Lactation
Leptin
/ blood
Male
Obesity
/ etiology
Pregnancy
Rats, Wistar
Sex Factors
Triglycerides
/ blood
calorie restriction
insulin resistance
metabolic programming
myo-inositol
obesity
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
08
01
2021
received:
03
10
2020
pubmed:
9
2
2021
medline:
1
1
2022
entrez:
8
2
2021
Statut:
ppublish
Résumé
To examine the effects of myo-inositol supplementation during lactation in male and female rats on metabolic parameters and its potential to reverse metabolic alterations associated with a moderate gestational calorie restriction. The offspring of control and 25% gestational calorie-restricted rats are supplemented with myo-inositol or vehicle throughout lactation and exposed to a Western diet (WD) from 5 to 7 months of age. Blood parameters are measured and gene expression and protein levels in retroperitoneal white adipose tissue (rWAT) and liver are analyzed. In male offspring, but not in females, myo-inositol supplementation resulted in lower fasting triglyceride and insulin levels and HOMA-IR at 7 months, and reversed the alterations in these parameters due to gestational calorie restriction. The expression pattern of key genes in metabolism in rWAT and liver support the beneficial effect of myo-inositol supplementation in reversing metabolic alterations programmed by gestational calorie restriction in male rats. Myo-inositol supplementation at physiological doses during lactation improves metabolic health and prevents the programmed trend to develop insulin resistance and hypertriglyceridemia in male rats acquired by inadequate fetal nutrition and exacerbated by a diabetogenic diet in adulthood. The absence of clear effects in females deserves further investigation.
Identifiants
pubmed: 33554468
doi: 10.1002/mnfr.202000965
doi:
Substances chimiques
Leptin
0
Triglycerides
0
Inositol
4L6452S749
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000965Informations de copyright
© 2021 Wiley-VCH GmbH.
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