Fusion Genes and RNAs in Cancer Development.
FISH
RNA sequence
RT-PCR
chromosomal rearrangements
cis-splicing
fusion RNAs
gene fusions
non-RT-based assay
trans-splicing
Journal
Non-coding RNA
ISSN: 2311-553X
Titre abrégé: Noncoding RNA
Pays: Switzerland
ID NLM: 101652294
Informations de publication
Date de publication:
04 Feb 2021
04 Feb 2021
Historique:
received:
31
12
2020
revised:
02
02
2021
accepted:
03
02
2021
entrez:
9
2
2021
pubmed:
10
2
2021
medline:
10
2
2021
Statut:
epublish
Résumé
Fusion RNAs are a hallmark of some cancers. They result either from chromosomal rearrangements or from splicing mechanisms that are non-chromosomal rearrangements. Chromosomal rearrangements that result in gene fusions are particularly prevalent in sarcomas and hematopoietic malignancies; they are also common in solid tumors. The splicing process can also give rise to more complex RNA patterns in cells. Gene fusions frequently affect tyrosine kinases, chromatin regulators, or transcription factors, and can cause constitutive activation, enhancement of downstream signaling, and tumor development, as major drivers of oncogenesis. In addition, some fusion RNAs have been shown to function as noncoding RNAs and to affect cancer progression. Fusion genes and RNAs will therefore become increasingly important as diagnostic and therapeutic targets for cancer development. Here, we discuss the function, biogenesis, detection, clinical relevance, and therapeutic implications of oncogenic fusion genes and RNAs in cancer development. Further understanding the molecular mechanisms that regulate how fusion RNAs form in cancers is critical to the development of therapeutic strategies against tumorigenesis.
Identifiants
pubmed: 33557176
pii: ncrna7010010
doi: 10.3390/ncrna7010010
pmc: PMC7931065
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 17KK0163
Organisme : Japan Society for the Promotion of Science
ID : 18H02570
Organisme : Japan Society for the Promotion of Science
ID : 18KT0016
Organisme : Japan Society for the Promotion of Science
ID : 20H04838
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