Alcohol Use Disorder and Its Comorbidity With HIV Infection Disrupts Anterior Cingulate Cortex Functional Connectivity.
Alcohol use disorder
Alcoholism
Anterior cingulate cortex
HIV infection
Hippocampus
Orbitofrontal cortex
Resting state
fMRI
Journal
Biological psychiatry. Cognitive neuroscience and neuroimaging
ISSN: 2451-9030
Titre abrégé: Biol Psychiatry Cogn Neurosci Neuroimaging
Pays: United States
ID NLM: 101671285
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
29
07
2020
revised:
16
11
2020
accepted:
17
11
2020
pubmed:
10
2
2021
medline:
10
11
2022
entrez:
9
2
2021
Statut:
ppublish
Résumé
Individuals with alcohol use disorder (AUD) have a heightened risk of contracting HIV infection. The effects of these two diseases and their comorbidity on brain structure have been well described, but their effects on brain function have never been investigated at the scale of whole-brain connectomes. In contrast with prior studies that restricted analyses to specific brain networks or examined relatively small groups of participants, our analyses are based on whole-brain functional connectomes of 292 participants. Relative to participants without AUD, the functional connectivity between the anterior cingulate cortex and orbitofrontal cortex was lower for participants with AUD. Compared with participants without AUD+HIV comorbidity, the functional connectivity between the anterior cingulate cortex and hippocampus was lower for the AUD+HIV participants. Compromised connectivity between these pairs was significantly correlated with greater total lifetime alcohol consumption; the effects of total lifetime alcohol consumption on executive functioning were significantly mediated by the functional connectivity between the pairs. Taken together, our results suggest that the functional connectivity of the anterior cingulate cortex is disrupted in individuals with AUD alone and AUD with HIV infection comorbidity. Moreover, the affected connections are associated with deficits in executive functioning, including heightened impulsiveness.
Sections du résumé
BACKGROUND
Individuals with alcohol use disorder (AUD) have a heightened risk of contracting HIV infection. The effects of these two diseases and their comorbidity on brain structure have been well described, but their effects on brain function have never been investigated at the scale of whole-brain connectomes.
METHODS
In contrast with prior studies that restricted analyses to specific brain networks or examined relatively small groups of participants, our analyses are based on whole-brain functional connectomes of 292 participants.
RESULTS
Relative to participants without AUD, the functional connectivity between the anterior cingulate cortex and orbitofrontal cortex was lower for participants with AUD. Compared with participants without AUD+HIV comorbidity, the functional connectivity between the anterior cingulate cortex and hippocampus was lower for the AUD+HIV participants. Compromised connectivity between these pairs was significantly correlated with greater total lifetime alcohol consumption; the effects of total lifetime alcohol consumption on executive functioning were significantly mediated by the functional connectivity between the pairs.
CONCLUSIONS
Taken together, our results suggest that the functional connectivity of the anterior cingulate cortex is disrupted in individuals with AUD alone and AUD with HIV infection comorbidity. Moreover, the affected connections are associated with deficits in executive functioning, including heightened impulsiveness.
Identifiants
pubmed: 33558196
pii: S2451-9022(20)30354-2
doi: 10.1016/j.bpsc.2020.11.012
pmc: PMC8160024
mid: NIHMS1650379
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1127-1136Subventions
Organisme : NIAAA NIH HHS
ID : U01 AA017347
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA010723
Pays : United States
Organisme : NIAAA NIH HHS
ID : U24 AA021697
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113406
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA023165
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA010723
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA005965
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA013521
Pays : United States
Informations de copyright
Copyright © 2020 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.