Replication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 02 2021
08 02 2021
Historique:
received:
17
07
2020
accepted:
29
12
2020
entrez:
9
2
2021
pubmed:
10
2
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Podoconiosis, a debilitating lymphoedema of the leg, results from barefoot exposure to volcanic clay soil in genetically susceptible individuals. A previous genome-wide association study (GWAS) conducted in the Wolaita ethnic group from Ethiopia showed association between single nucleotide polymorphisms (SNPs) in the HLA class II region and podoconiosis. We aimed to conduct a second GWAS in a new sample (N = 1892) collected from the Wolaita and two other Ethiopian populations, the Amhara and the Oromo, also affected by podoconiosis. Fourteen SNPs in the HLA class II region showed significant genome-wide association (P < 5.0 × 10
Identifiants
pubmed: 33558538
doi: 10.1038/s41598-021-81836-x
pii: 10.1038/s41598-021-81836-x
pmc: PMC7870958
doi:
Substances chimiques
HLA-DRB1 Chains
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3285Subventions
Organisme : Medical Research Council
ID : MR/J008621/1
Pays : United Kingdom
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