Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 02 2021
08 02 2021
Historique:
received:
23
06
2020
accepted:
14
01
2021
entrez:
9
2
2021
pubmed:
10
2
2021
medline:
17
2
2021
Statut:
epublish
Résumé
Chimeric antigen receptor T cell (CAR-T) targeting the CD19 antigen represents an innovative therapeutic approach to improve the outcome of relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). Yet, despite a high initial remission rate, CAR-T therapy ultimately fails for some patients. Notably, around half of relapsing patients develop CD19 negative (CD19
Identifiants
pubmed: 33558546
doi: 10.1038/s41467-021-21168-6
pii: 10.1038/s41467-021-21168-6
pmc: PMC7870924
doi:
Substances chimiques
Antigens, CD19
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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