Cannabidiol in the Treatment of Epilepsy.
Journal
Clinical drug investigation
ISSN: 1179-1918
Titre abrégé: Clin Drug Investig
Pays: New Zealand
ID NLM: 9504817
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
accepted:
15
01
2021
pubmed:
10
2
2021
medline:
5
5
2021
entrez:
9
2
2021
Statut:
ppublish
Résumé
Anecdotal reports addressing the successful seizure treatment of severe epilepsies with cannabidiol (CBD) have increased both public interest and academic research. Placebo-controlled, randomized, controlled trials proved the efficacy of pharmaceutical-grade CBD in epilepsy treatment, thus leading to pharmaceutical-grade CBD approval by the US Food and Drug Administration and the European Medicines Agency for the treatment of seizures in Dravet syndrome and Lennox-Gastaut syndrome as well as for tuberous complex syndrome by the Food and Drug Administration only. However, the CBD market is confusing because an array of products of different origins, purity, and concentration is available. Additionally, the results from the pivotal studies with plant-derived, pharmaceutical-grade CBD cannot simply be transferred to other epilepsy types or CBD of any origin. Because of the high demands and expectations that patients with epilepsy and their caregivers have regarding CBD, information outlining the proven facts and potential risks is essential. The aim of this article is to thoroughly review available research data and practical recommendations to provide the treating physician with the necessary information for counseling patients with epilepsy.
Identifiants
pubmed: 33559102
doi: 10.1007/s40261-021-01003-y
pii: 10.1007/s40261-021-01003-y
pmc: PMC7946683
doi:
Substances chimiques
Anticonvulsants
0
Cannabidiol
19GBJ60SN5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
211-220Références
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