Reproductive Characteristics and Pregnancy Outcomes in Hidden Celiac Disease Autoimmunity.
Journal
The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
received:
31
07
2020
accepted:
22
12
2020
pubmed:
10
2
2021
medline:
16
3
2021
entrez:
9
2
2021
Statut:
ppublish
Résumé
Untreated symptomatic celiac disease (CD) adversely affects female reproduction; however, the effect of hidden CD autoimmunity is uncertain. We identified women who were not previously diagnosed with CD and tested positive for tissue transglutaminase and endomysial antibodies between 2006 and 2011 in a community-based retrospective cohort study. We evaluated (i) the rate of adverse pregnancy outcomes and medical complications of pregnancy in successful singleton deliveries and (ii) reproductive characteristics in seropositive women without a clinical diagnosis of CD and age-matched seronegative women. Among 17,888 women whose serum samples were tested for CD autoimmunity, 215 seropositive and 415 seronegative women were included. We reviewed 231 and 509 live singleton deliveries of 117 seropositive and 250 seronegative mothers, respectively. Menarche and menopausal age, gravidity, parity, and age at first child were similar in seropositive and seronegative women. CD seropositivity was not associated with an increased risk of maternal pregnancy complications. Maternal seropositivity was associated with small for gestational age in boys (OR 3.77, 95% CI: 1.47-9.71; P = 0.006), but not in girls (OR 0.57, 95% CI: 0.15-2.17; P = 0.41). CD serum positivity was not associated with prematurity, small for gestational age (birth weight <10th percentile), or 5-minute Apgar score of less than 7. Although underpowered, the present study did not show any difference in reproductive characteristics or rates of adverse pregnancy outcomes in women with and without CD autoimmunity, except for birth weight in male offspring. Larger studies are needed to determine the effects of CD autoimmunity on female reproduction.
Identifiants
pubmed: 33560653
doi: 10.14309/ajg.0000000000001148
pii: 00000434-202103000-00028
doi:
Substances chimiques
Autoantibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
593-599Informations de copyright
Copyright © 2021 by The American College of Gastroenterology.
Références
Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States. Arch Intern Med 2003;163:286.
Choung RS, Larson SA, Khaleghi S, et al. Prevalence and morbidity of undiagnosed celiac disease from a community-based study. Gastroenterology 2017;152:830–9.e5.
Kurppa K, Paavola A, Collin P, et al. Benefits of a gluten-free diet for asymptomatic patients with serologic markers of celiac disease. Gastroenterology 2014;147:610–7.e1.
West J. Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 2003;52:960–5.
Norgard B, Fonager K, Sorensen HT, et al. Birth outcomes of women with celiac disease: A nationwide historical cohort study. Am J Gastroenterol 1999;94:2435–40.
Ludvigsson JF, Montgomery SM, Ekbom A. Celiac disease and risk of adverse fetal outcome: A population-based cohort study. Gastroenterology 2005;129:454–63.
Khashan AS, Henriksen TB, Mortensen PB, et al. The impact of maternal celiac disease on birthweight and preterm birth: A Danish population-based cohort study. Hum Reprod 2010;25:528–34.
Saccone G, Berghella V, Sarno L, et al. Celiac disease and obstetric complications: A systematic review and metaanalysis. Am J Obstet Gynecol 2016;214:225–34.
Tersigni C, Castellani R, de Waure C, et al. Celiac disease and reproductive disorders: meta-analysis of epidemiologic associations and potential pathogenic mechanisms. Hum Reprod Update 2014;20:582–93.
Barker DJ. The developmental origins of chronic adult disease. Acta Paediatr Suppl 2004;93:26–33.
Lisonkova S, Sabr Y, Mayer C, et al. Maternal morbidity associated with early-onset and late-onset preeclampsia. Obstet Gynecol 2014;124:771–81.
Mårild K, Stephansson O, Montgomery S, et al. Pregnancy outcome and risk of celiac disease in offspring: A nationwide case-control study. Gastroenterology 2012;142:39–45.e3.
Sandberg-Bennich S, Dahlquist G, Källén B. Coeliac disease is associated with intrauterine growth and neonatal infections. Acta Paediatr 2002;91:30–3.
Walker MM, Murray JA, Ronkainen J, et al. Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study. Gastroenterology 2010;139:112–9.
Katz KD, Rashtak S, Lahr BD, et al. Screening for celiac disease in a North American population: Sequential serology and gastrointestinal symptoms. Am J Gastroenterol 2011;106:1333–9.
Kumar V, Lerner A, Valeski JE, et al. Endomysial antibodies in the diagnosis of celiac disease and the effect of gluten on antibody titers. Immunol Invest 1989;18:533–44.
Murray JA, Herlein J, Mitros F, et al. Serologic testing for celiac disease in the United States: Results of a multilaboratory comparison study. 2000;7:584–7.
Choung RS, Khaleghi S, Cartee AK, et al. Community-based study of celiac disease autoimmunity progression in adults. Gastroenterology 2020;158:151–159.e153.
Biagi F, Trotta L, Alfano C, et al. Prevalence and natural history of potential celiac disease in adult patients. Scand J Gastroenterol 2013;48:537–42.
Vilppula A, Kaukinen K, Luostarinen L, et al. Increasing prevalence and high incidence of celiac disease in elderly people. A population-based study 2009;9:49.
Abdul Sultan A, Tata LJ, Fleming KM, et al. Pregnancy complications and adverse birth outcomes among women with celiac disease: A population-based study from England. Am J Gastroenterol 2014;109:1653–61.
Kiefte-de Jong JC, Jaddoe VW, Uitterlinden AG, et al. Levels of antibodies against tissue transglutaminase during pregnancy are associated with reduced fetal weight and birth weight. Gastroenterology 2013;144:726–35.e2.
Martinelli P, Troncone R, Paparo F, et al. Coeliac disease and unfavourable outcome of pregnancy. Gut 2000;46:332–5.
Ciacci C, Cirillo M, Auriemma G, et al. Celiac disease and pregnancy outcome. Am J Gastroenterol 1996;91:718–22.
Greco L, Veneziano A, Di Donato L, et al. Undiagnosed coeliac disease does not appear to be associated with unfavourable outcome of pregnancy. Gut 2004;53:149–51.
Gasbarrini A, Torre ES, Trivellini C, et al. Recurrent spontaneous abortion and intrauterine fetal growth retardation as symptoms of coeliac disease. Lancet 2000;356:399–400.
Sharma KA, Kumar A, Kumar N, et al. Celiac disease in intrauterine growth restriction. Int J Gynaecol Obstet 2007;98:57–9.
Salvatore S, Finazzi S, Radaelli G, et al. Prevalence of undiagnosed celiac disease in the parents of preterm and/or small for gestational age infants. Am J Gastroenterol 2007;102:168–73.
Wolf H, Ilsen A, van Pampus MG, et al. Celiac serology in women with severe pre-eclampsia or delivery of a small for gestational age neonate. Int J Gynaecol Obstet 2008;103:175–7.
Kumar A, Meena M, Begum N, et al. Latent celiac disease in reproductive performance of women. Fertil Steril 2011;95:922–7.
St Sauver JL, Grossardt BR, Leibson CL, et al. Generalizability of epidemiological findings and public health decisions: An illustration from the Rochester Epidemiology Project. Mayo Clinic Proc 2012;87:151–60.
St Sauver JL, Grossardt BR, Yawn BP, et al. Use of a medical records linkage system to enumerate a dynamic population over time: The Rochester Epidemiology Project. Am J Epidemiol 2011;173:1059–68.
Rocca WA, Yawn BP, St Sauver JL, et al. History of the Rochester Epidemiology Project: Half a century of medical records linkage in a US population. Mayo Clinic Proc 2012;87:1202–13.
Olsen IE, Groveman SA, Lawson ML, et al. New intrauterine growth curves based on United States data. Pediatrics 2010;125:e214–24.
ACOG committee opinion no. 548: Weight gain during pregnancy. Obstet Gynecol 2013;121:210–2.
Grode L, Bech BH, Plana-Ripoll O, et al. Reproductive life in women with celiac disease; a nationwide, population-based matched cohort study. Hum Reprod 2018;33:1538–1547.
Zugna D, Richiardi L, Akre O, et al. A nationwide population-based study to determine whether coeliac disease is associated with infertility. Gut 2010;59:1471–5.
Kotze LMS. Gynecologic and obstetric findings related to nutritional status and adherence to a gluten-free diet in Brazilian patients with celiac disease. J Clin Gastroenterol 2004;38:567–74.
Bledsoe AC, King KS, Larson JJ, et al. Micronutrient deficiencies are common in contemporary celiac disease despite lack of overt malabsorption symptoms. Mayo Clin Proc 2019;94:1253–60.
Di Simone N, Silano M, Castellani R, et al. Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro. Am J Gastroenterol 2010;105:2254–61.
Simon-Vecsei Z, Kiraly R, Bagossi P, et al. A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effects. Proc Natl Acad Sci 2012;109:431–6.
Anjum N, Baker PN, Robinson NJ, et al. Maternal celiac disease autoantibodies bind directly to syncytiotrophoblast and inhibit placental tissue transglutaminase activity. Reprod Biol Endocrinol 2009;7:16.
Catassi C, Kryszak D, Bhatti B, et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med 2010;42:530–8.
Clifton VL. Review: Sex and the human placenta: Mediating differential strategies of fetal growth and survival. Placenta 2010;31(Suppl):S33–9.
DiPietro JA, Voegtline KM. The gestational foundation of sex differences in development and vulnerability. Neuroscience 2017;342:4–20.
Gualtieri T, Hicks RE. An immunoreactive theory of selective male affliction. Behav Brain Sci 1985;8:427–41.
Lakshmanan A, Chiu Y-HM, Coull BA, et al. Associations between prenatal traffic-related air pollution exposure and birth weight: Modification by sex and maternal pre-pregnancy body mass index. Environ Res 2015;137:268–77.
Sher KS, Mayberry JF. Female fertility, obstetric and gynaecological history in coeliac disease: A case control study. Acta Paediatr Suppl 1996;412:76–7.
Smecuol E, Maurino E, Vazquez H, et al. Gynaecological and obstetric disorders in coeliac disease: Frequent clinical onset during pregnancy or the puerperium. Eur J Gastroenterol Hepatol 1996;8:63–89.
Tata LJ, Card TR, Logan RF, et al. Fertility and pregnancy-related events in women with celiac disease: A population-based cohort study. Gastroenterology 2005;128:849–55.