Membrane Filtration-Assisted Enzymatic Hydrolysis Affects the Biological Activity of Potato Juice.
antioxidant activity
antiproliferative activity
cancer cells
cytotoxicity
in vitro study
nutritional value
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Feb 2021
06 Feb 2021
Historique:
received:
19
01
2021
revised:
02
02
2021
accepted:
03
02
2021
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
12
5
2021
Statut:
epublish
Résumé
The results of recently published studies indicate that potato juice is characterized by interesting biological activity that can be particularly useful in the case of gastrointestinal symptoms. Moreover, the studies also described the high nutritional value of its proteins. This article is a report on the impact of the enzymatic hydrolysis of proteins combined with membrane filtration. The obtained potato juice protein hydrolysate (PJPH) and its concentrate (cPJPH) were characterized in terms of their nutritional value and biological activity. The amino acid profile and scoring, the content of mineral compounds, and the antioxidant and in vitro cytotoxic activity were assessed. The study proved that the antioxidant activity of PJPH is higher than that of fresh potato juice, and the cytotoxicity against human gastric carcinoma cell line (Hs 746T), human colon cancer cell line (Caco-2), human colorectal adenocarcinoma cell line (HT-29), and human normal colon mucosa cell line (CCD 841 CoN) showed biological activity specifically targeted against cancer cells. Therefore, it can be concluded that the membrane filtration-assisted enzymatic hydrolysis of potato juice proteins may increase their biological activity and allow for potato juice to be used in the production of medicinal preparations.
Identifiants
pubmed: 33561978
pii: molecules26040852
doi: 10.3390/molecules26040852
pmc: PMC7914785
pii:
doi:
Substances chimiques
Serine Endopeptidases
EC 3.4.21.-
microbial serine proteinases
EC 3.4.21.62
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Centre (Poland)
ID : 2019/03/X/NZ9/00229
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