Paroxetine-Overview of the Molecular Mechanisms of Action.
CYP
EBOV
GRK2
MAT
paroxetine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Feb 2021
07 Feb 2021
Historique:
received:
28
12
2020
revised:
31
01
2021
accepted:
04
02
2021
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
13
4
2021
Statut:
epublish
Résumé
In the 21st century and especially during a pandemic, the diagnosis and treatment of depression is an essential part of the daily practice of many family doctors. It mainly affects patients in the age category 15-44 years, regardless of gender. Anxiety disorders are often diagnosed in children and adolescents. Social phobias can account for up to 13% of these diagnoses. Social anxiety manifests itself in fear of negative social assessment and humiliation, which disrupts the quality of social functioning. Treatment of the above-mentioned disorders is based on psychotherapy and pharmacotherapy. Serious side effects or mortality from antidepressant drug overdose are currently rare. Recent studies indicate that paroxetine (ATC code: N06AB), belonging to the selective serotonin reuptake inhibitors, has promising therapeutic effects and is used off-label in children and adolescents. The purpose of this review is to describe the interaction of paroxetine with several molecular targets in various points of view including the basic chemical and pharmaceutical properties. The central point of the review is focused on the pharmacodynamic analysis based on the molecular mechanism of binding paroxetine to various therapeutic targets.
Identifiants
pubmed: 33562229
pii: ijms22041662
doi: 10.3390/ijms22041662
pmc: PMC7914979
pii:
doi:
Substances chimiques
Antidepressive Agents, Second-Generation
0
Serotonin Antagonists
0
Paroxetine
41VRH5220H
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Clin Pharmacokinet. 1998 Nov;35(5):361-90
pubmed: 9839089
Medicine (Baltimore). 2020 Apr;99(14):e19573
pubmed: 32243377
Sci Rep. 2015 Oct 27;5:15650
pubmed: 26503701
Pain Res Manag. 2016;2016:2020915
pubmed: 27445601
Cancers (Basel). 2019 Jan 09;11(1):
pubmed: 30634506
Onco Targets Ther. 2016 Sep 08;9:5495-505
pubmed: 27660467
Cochrane Database Syst Rev. 2010 Mar 17;(3):CD006932
pubmed: 20238352
Nat Rev Drug Discov. 2007 Sep;6(9):734-45
pubmed: 17690708
J Anxiety Disord. 2012 Jun;26(5):608-16
pubmed: 22445318
Nat Struct Mol Biol. 2018 Feb;25(2):170-175
pubmed: 29379174
ACS Chem Biol. 2012 Nov 16;7(11):1830-9
pubmed: 22882301
Protein Pept Lett. 2011 Jul;18(7):670-8
pubmed: 21413918
Neuropharmacology. 2019 Dec 15;161:107411
pubmed: 30391505
Nature. 2005 Sep 8;437(7056):215-23
pubmed: 16041361
Sci Rep. 2016 Apr 01;6:23789
pubmed: 27032980
Xenobiotica. 1998 Dec;28(12):1203-53
pubmed: 9890159
Pharmacol Ther. 2013 Apr;138(1):103-41
pubmed: 23333322
Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58
pubmed: 9537821
Mol Pharmacol. 2018 Apr;93(4):251-258
pubmed: 29298813
Nat Med. 2007 Mar;13(3):315-23
pubmed: 17322894
Curr Drug Metab. 2008 May;9(4):310-22
pubmed: 18473749
Curr Opin Struct Biol. 2019 Feb;54:161-170
pubmed: 30921707
Am Fam Physician. 2003 Aug 1;68(3):498-504
pubmed: 12924832
Acta Psychiatr Scand Suppl. 1989;350:60-75
pubmed: 2530793
Curr Probl Pediatr Adolesc Health Care. 2010 Apr;40(4):66-99
pubmed: 20381781
Sci Rep. 2019 Sep 10;9(1):13053
pubmed: 31506468
J Pharmacol Exp Ther. 2013 Jul;346(1):113-20
pubmed: 23633618
Int J Psychiatry Clin Pract. 2016;20(1):47-51
pubmed: 26750572
Cardiol Young. 2019 Oct;29(10):1300-1301
pubmed: 31475669
J Mol Model. 2009 Oct;15(10):1155-64
pubmed: 19238460
J Biol Chem. 2006 Mar 17;281(11):7614-22
pubmed: 16352597
Curr Med Res Opin. 2003;19(1):13-21
pubmed: 12661775
Nature. 2002 Jan 10;415(6868):206-12
pubmed: 11805844
Int J Emerg Ment Health. 2014;16(1):247-50
pubmed: 25345238
Acta Psychiatr Scand. 2007 Mar;115(3):169-70
pubmed: 17302616
J Clin Psychopharmacol. 1996 Feb;16(1):3-8
pubmed: 8834412
Mol Pharmacol. 2014 Feb;85(2):237-48
pubmed: 24220010
Am J Physiol. 1990 Aug;259(2 Pt 1):C196-204
pubmed: 2143355
Eur J Pharmacol. 2019 Dec 15;865:172732
pubmed: 31622593
J Chromatogr Sci. 2014 Nov-Dec;52(10):1217-23
pubmed: 24448669
J Cell Mol Med. 2019 Feb;23(2):1106-1115
pubmed: 30421568
Depress Anxiety. 2014 Jun;31(6):472-9
pubmed: 24395386
Breast Cancer Res. 2020 Sep 29;22(1):103
pubmed: 32993785
J Mol Med (Berl). 2009 May;87(5):455-63
pubmed: 19229505
Cochrane Database Syst Rev. 2012 Nov 14;11:CD004851
pubmed: 23152227
Nature. 2013 Nov 7;503(7474):85-90
pubmed: 24037379
J Med Chem. 2018 Feb 8;61(3):724-733
pubmed: 29272110
Expert Rev Neurother. 2007 Feb;7(2):107-20
pubmed: 17286545
J Virol. 2008 Mar;82(6):2699-704
pubmed: 18199658
Circ Res. 2008 Aug 15;103(4):413-22
pubmed: 18635825
Arch Gen Psychiatry. 2006 Mar;63(3):332-9
pubmed: 16520440
J Mol Model. 2020 Jul 4;26(8):197
pubmed: 32623519
ACS Chem Biol. 2017 Oct 20;12(10):2558-2562
pubmed: 28910072
AAPS J. 2017 Nov 27;20(1):6
pubmed: 29181593
ESC Heart Fail. 2020 Aug;7(4):1571-1584
pubmed: 32352228
Curr Drug Metab. 2012 Feb;13(2):167-76
pubmed: 22208531
Int J Psychiatry Clin Pract. 2012 Jun;16(2):77-84
pubmed: 22540422
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617
pubmed: 29140435
Biochemistry. 2005 May 10;44(18):6958-70
pubmed: 15865441
J Pharmacol Exp Ther. 2015 Jul;354(1):43-54
pubmed: 25943764
Mol Pharm. 2012 Dec 3;9(12):3515-25
pubmed: 23051151
Drug Metabol Drug Interact. 2012;27(4):185-97
pubmed: 23152403
Nature. 2016 Apr 21;532(7599):334-9
pubmed: 27049939
Pharmacol Res. 2016 Aug;110:52-64
pubmed: 27180008
Curr Top Med Chem. 2009;9(9):755-70
pubmed: 19754393
World J Cardiol. 2015 Apr 26;7(4):204-14
pubmed: 25914789
Oncotarget. 2017 Jun 15;8(33):55750-55759
pubmed: 28903457
Cell Rep. 2019 Feb 12;26(7):1841-1853.e6
pubmed: 30759394
J Med Chem. 2017 Apr 13;60(7):3052-3069
pubmed: 28323425
Pharm Res. 1988 Feb;5(2):67-75
pubmed: 3073382
J Mol Cell Cardiol. 2001 May;33(5):887-905
pubmed: 11343413
Nature. 2013 Nov 7;503(7474):141-5
pubmed: 24121440
Acad Pediatr. 2009 Mar-Apr;9(2):81-8
pubmed: 19329098
J Am Acad Dermatol. 2020 Nov;83(5):1487-1489
pubmed: 32473973
Clin Exp Vaccine Res. 2015 Jan;4(1):17-22
pubmed: 25648530
Drugs. 2017 Dec;77(18):1987-2001
pubmed: 29139090
Toxicol Sci. 2014 May;139(1):198-209
pubmed: 24496634
Expert Opin Ther Targets. 2018 Jan;22(1):75-83
pubmed: 29166798
J Biol Chem. 2012 Dec 21;287(52):43694-707
pubmed: 23086945
Int J Mol Sci. 2018 May 30;19(6):
pubmed: 29848998
Front Pharmacol. 2019 Feb 19;10:112
pubmed: 30837878
J Clin Pharmacol. 2006 Dec;46(12):1426-38
pubmed: 17101742
Profiles Drug Subst Excip Relat Methodol. 2013;38:367-406
pubmed: 23668408
Toxicol Sci. 2015 Oct;147(2):446-57
pubmed: 26141389
Arch Gen Psychiatry. 1981 Nov;38(11):1278-82
pubmed: 7305609
CNS Drug Rev. 2001 Spring;7(1):25-47
pubmed: 11420571
AAPS J. 2012 Dec;14(4):759-63
pubmed: 22826034
Am J Public Health. 2006 Oct;96(10):1744-51
pubmed: 17008567
Am J Psychiatry. 1990 Feb;147(2):207-10
pubmed: 2301661
Pediatrics. 2010 May;125(5):876-88
pubmed: 20385637
Mol Cancer. 2018 Feb 19;17(1):36
pubmed: 29455664
Curr Drug Metab. 2008 Sep;9(7):598-610
pubmed: 18781911
J Clin Oncol. 2007 Mar 1;25(7):884-96
pubmed: 17327610
Clin Chim Acta. 2019 Jan;488:196-201
pubmed: 30439354
J Chem Inf Model. 2011 Oct 24;51(10):2778-86
pubmed: 21919503
Medicine (Baltimore). 2018 Jul;97(28):e11547
pubmed: 29995828
Nat Rev Drug Discov. 2017 Dec;16(12):829-842
pubmed: 29075003
Curr Drug Metab. 2006 Oct;7(7):705-14
pubmed: 17073575
J Psychopharmacol. 2005 Nov;19(6):567-96
pubmed: 16272179
Mol Pharmacol. 2011 Aug;80(2):294-303
pubmed: 21596927
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Org Biomol Chem. 2020 May 6;18(17):3334-3345
pubmed: 32301459
Nature. 2016 Jul 7;535(7610):169-172
pubmed: 27362232
Int J Adolesc Med Health. 2005 Jul-Sep;17(3):211-20
pubmed: 16231472
Encephale. 2005 May-Jun;31(3):309-16
pubmed: 16142045
Elife. 2020 Jul 03;9:
pubmed: 32618269
Psychopharmacol Bull. 2016 Mar 1;46(1):77-104
pubmed: 27738376
Acta Psychiatr Scand Suppl. 1989;350:24-6
pubmed: 2530779
BMJ. 2016 Jan 28;352:i545
pubmed: 26821942
Future Med Chem. 2010 Sep;2(9):1451-68
pubmed: 21103389
Nat Prod Rep. 2002 Aug;19(4):477-93
pubmed: 12195813
Int J Neuropsychopharmacol. 2015 Jul 18;19(2):
pubmed: 26188343
Magn Reson Chem. 2005 Nov;43(11):910-7
pubmed: 16052604
J Biol Inorg Chem. 2017 Apr;22(2-3):209-220
pubmed: 28091754
Expert Opin Pharmacother. 2008 Apr;9(5):787-94
pubmed: 18345955
Clin Ther. 2014 Jul 1;36(7):1074-86
pubmed: 25047498
Genes (Basel). 2020 Oct 30;11(11):
pubmed: 33143137