CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy.
Animals
CD8-Positive T-Lymphocytes
/ immunology
Folate Receptor 2
/ immunology
Humans
Immunosuppression Therapy
Immunotherapy, Adoptive
/ methods
Mesothelin
Mice
Mice, Inbred C57BL
Monocytes
/ immunology
Neoplasms
/ immunology
Receptors, Chimeric Antigen
/ immunology
Tumor Cells, Cultured
Tumor Microenvironment
/ immunology
Tumor-Associated Macrophages
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 02 2021
09 02 2021
Historique:
received:
27
04
2020
accepted:
22
12
2020
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
24
2
2021
Statut:
epublish
Résumé
The immunosuppressive tumor microenvironment (TME) represents a major barrier for effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous and plastic cell components of the TME which can either promote tumor progression (M2-like) or boost antitumor immunity (M1-like). Here, we demonstrate that a subset of TAMs that express folate receptor β (FRβ) possess an immunosuppressive M2-like profile. In syngeneic tumor mouse models, chimeric antigen receptor (CAR)-T cell-mediated selective elimination of FRβ
Identifiants
pubmed: 33563975
doi: 10.1038/s41467-021-20893-2
pii: 10.1038/s41467-021-20893-2
pmc: PMC7873057
doi:
Substances chimiques
Folate Receptor 2
0
Msln protein, mouse
0
Receptors, Chimeric Antigen
0
Mesothelin
J27WDC343N
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
877Subventions
Organisme : NCI NIH HHS
ID : R01 CA226983
Pays : United States
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