Integrated immune dynamics define correlates of COVID-19 severity and antibody responses.

Adaptive Immunity Adult Aged Antibodies, Viral / blood Antibody Formation B-Lymphocytes / cytology COVID-19 / immunology Female Humans Immunity, Innate Interleukin-18 / metabolism Interleukin-6 / metabolism Male Middle Aged Receptors, CXCR3 / metabolism Receptors, Interleukin-6 / metabolism SARS-CoV-2 / immunology Severity of Illness Index Th1 Cells / cytology Young Adult
CD38 HLA-DR IL-18 IL-6 SARS-CoV-2 T follicular helper cells acute COVID-19 antibody-secreting cells convalescent COVID-19 soluble IL-6 receptor

Journal

Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894

Informations de publication

Date de publication:
16 03 2021
Historique:
received: 17 09 2020
revised: 05 11 2020
accepted: 01 02 2021
pubmed: 11 2 2021
medline: 11 2 2021
entrez: 10 2 2021
Statut: ppublish

Résumé

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or convalescent time points, up to 102 days after symptom onset, quantifying 184 immunological parameters. Acute COVID-19 presented with high levels of IL-6, IL-18, and IL-10 and broad activation marked by the upregulation of CD38 on innate and adaptive lymphocytes and myeloid cells. Importantly, activated CXCR3

Identifiants

DOI: 10.1016/j.xcrm.2021.100208 PMID: 33564749 PMC: PMC7862905
pubmed: 33564749
doi: 10.1016/j.xcrm.2021.100208
pii: S2666-3791(21)00019-7
pmc: PMC7862905
doi:

Substances chimiques

Antibodies, Viral 0
CXCR3 protein, human 0
Interleukin-18 0
Interleukin-6 0
Receptors, CXCR3 0
Receptors, Interleukin-6 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

100208

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Références

Nat Med. 2020 Sep;26(9):1428-1434
pubmed: 32661393
Sci Transl Med. 2018 Feb 14;10(428):
pubmed: 29444980
J Immunol. 2019 Jan 15;202(2):360-367
pubmed: 30617117
Immunity. 2015 Sep 15;43(3):591-604
pubmed: 26362266
Nature. 2020 Aug;584(7821):463-469
pubmed: 32717743
Immunity. 2020 Oct 13;53(4):864-877.e5
pubmed: 32791036
J Immunol. 2015 Apr 15;194(8):3890-900
pubmed: 25732728
Nature. 2016 May 5;533(7601):100-4
pubmed: 27147028
Nature. 2020 Jul;583(7816):437-440
pubmed: 32434211
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
Med J Aust. 2020 Jun;212(10):459-462
pubmed: 32237278
Int J Mol Sci. 2019 Feb 02;20(3):
pubmed: 30717382
Cytometry A. 2011 Feb;79(2):167-74
pubmed: 21265010
Front Immunol. 2018 Apr 20;9:763
pubmed: 29731751
Am J Respir Crit Care Med. 2014 Feb 15;189(4):449-62
pubmed: 24308446
Nat Med. 2020 Apr;26(4):453-455
pubmed: 32284614
Sci Transl Med. 2017 Jun 7;9(393):
pubmed: 28592561
Methods Mol Biol. 2019;1989:159-192
pubmed: 31077106
Virology. 2013 Jan 5;435(1):157-69
pubmed: 23217625
Nat Med. 2020 Jul;26(7):1033-1036
pubmed: 32398876
Nat Med. 2020 Aug;26(8):1200-1204
pubmed: 32555424
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Nat Commun. 2015 Dec 21;6:10224
pubmed: 26687547
J Exp Med. 2019 Aug 5;216(8):1857-1873
pubmed: 31175140
JAMA Intern Med. 2020 Sep 1;180(9):1152-1154
pubmed: 32602883
Sci Immunol. 2020 Jun 26;5(48):
pubmed: 32591408
J Immunol. 2008 Jun 1;180(11):7102-6
pubmed: 18490707
Curr Protoc Microbiol. 2020 Jun;57(1):e100
pubmed: 32302069
Cell. 2020 Oct 1;183(1):143-157.e13
pubmed: 32877699
J Stat Softw. 2017 Aug;79:
pubmed: 30686944
Science. 2020 May 1;368(6490):473-474
pubmed: 32303591
PLoS One. 2016 Mar 01;11(3):e0150018
pubmed: 26930607
Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24384-24391
pubmed: 32913053
Nat Commun. 2018 Feb 26;9(1):824
pubmed: 29483513
Nat Rev Drug Discov. 2020 May;19(5):305-306
pubmed: 32273591
Bioinformatics. 2014 Oct;30(19):2811-2
pubmed: 24930139
Sci Rep. 2019 Jul 12;9(1):10090
pubmed: 31300682
Front Med (Lausanne). 2020 Oct 28;7:583897
pubmed: 33195334
Nature. 2020 Jul;583(7816):366-368
pubmed: 32661414
J Virol. 2016 Nov 28;90(24):11259-11278
pubmed: 27707928
Cytometry A. 2020 Mar;97(3):268-278
pubmed: 31633883
Science. 2020 Sep 4;369(6508):
pubmed: 32669297
Cancer Discov. 2016 Jun;6(6):664-79
pubmed: 27076371
Hepatology. 2014 Mar;59(3):803-13
pubmed: 24123114
Clin Transl Immunology. 2020 May 13;9(5):e1129
pubmed: 32419947
JCI Insight. 2020 Sep 3;5(17):
pubmed: 32706339
Nat Med. 2020 Oct;26(10):1623-1635
pubmed: 32807934
J Infect Dis. 2018 Jan 4;217(2):245-256
pubmed: 29112724
Cytometry A. 2015 Jul;87(7):636-45
pubmed: 25573116
Lancet Rheumatol. 2020 Oct;2(10):e579-e580
pubmed: 32838322
Nat Immunol. 2019 May;20(5):613-625
pubmed: 30778243
Cells. 2020 Jan 16;9(1):
pubmed: 31963337
Sci Immunol. 2020 Jul 15;5(49):
pubmed: 32669287
Cell Host Microbe. 2020 Sep 9;28(3):364-370
pubmed: 32798444
JCI Insight. 2020 Sep 3;5(17):
pubmed: 32687484
J Immunol. 2015 May 15;194(10):4836-45
pubmed: 25870238
Cold Spring Harb Perspect Biol. 2018 Feb 1;10(2):
pubmed: 28620096
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):769-74
pubmed: 24367104

Auteurs

Marios Koutsakos (M)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Louise C Rowntree (LC)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Luca Hensen (L)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Brendon Y Chua (BY)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan.

Carolien E van de Sandt (CE)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Jennifer R Habel (JR)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Wuji Zhang (W)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Xiaoxiao Jia (X)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Lukasz Kedzierski (L)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC, Australia.

Thomas M Ashhurst (TM)

Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney, Sydney, NSW, Australia.
Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, NSW, Australia.

Givanna H Putri (GH)

Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
School of Computer Science, University of Sydney, Sydney, NSW, Australia.

Felix Marsh-Wakefield (F)

Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Vascular Immunology Unit, Discipline of Pathology, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.

Mark N Read (MN)

Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
School of Computer Science, University of Sydney, Sydney, NSW, Australia.
The Westmead Initiative, University of Sydney, Sydney, NSW, Australia.

Davis N Edwards (DN)

School of Computer Science, University of Sydney, Sydney, NSW, Australia.
The Westmead Initiative, University of Sydney, Sydney, NSW, Australia.

E Bridie Clemens (EB)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Chinn Yi Wong (CY)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Francesca L Mordant (FL)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Jennifer A Juno (JA)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Fatima Amanat (F)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.

Jennifer Audsley (J)

Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Natasha E Holmes (NE)

Department of Infectious Diseases, Austin Hospital, Heidelberg, VIC, Australia.
Department of Medicine and Radiology, University of Melbourne, Parkville, VIC, Australia.
Data Analytics Research and Evaluation (DARE) Centre, Austin Health and University of Melbourne, Heidelberg, VIC, Australia.
Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.

Claire L Gordon (CL)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Department of Infectious Diseases, Austin Hospital, Heidelberg, VIC, Australia.

Olivia C Smibert (OC)

Department of Infectious Diseases, Austin Hospital, Heidelberg, VIC, Australia.
Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.
National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.

Jason A Trubiano (JA)

Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.
Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.
National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, VIC, Australia.

Carly M Hughes (CM)

Monash Infectious Diseases, Monash Medical Centre, Monash Health, Melbourne, VIC, Australia.

Mike Catton (M)

Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Justin T Denholm (JT)

Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Victorian Infectious Diseases Services, Royal Melbourne Hospital and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne VIC, Australia.

Steven Y C Tong (SYC)

Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Victorian Infectious Diseases Services, Royal Melbourne Hospital and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne VIC, Australia.
Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.

Denise L Doolan (DL)

Centre for Molecular Therapeutics, Australian Institute of Tropical Health & Medicine, James Cook University, Cairns, QLD, Australia.

Tom C Kotsimbos (TC)

Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Department of Allergy, Immunology, and Respiratory Medicine, Alfred Hospital, Melbourne, VIC, Australia.

David C Jackson (DC)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan.

Florian Krammer (F)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Dale I Godfrey (DI)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Australian Research Council Centre of Excellence for Advanced Molecular Imaging at the University of Melbourne, Melbourne, VIC, Australia.

Amy W Chung (AW)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Nicholas J C King (NJC)

Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney, Sydney, NSW, Australia.
Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, NSW, Australia.
Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Viral Immunopathology Laboratory, Discipline of Pathology, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.
Sydney Nano, University of Sydney, Sydney, NSW 2006, Australia.

Sharon R Lewin (SR)

Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Victorian Infectious Diseases Services, Royal Melbourne Hospital and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne VIC, Australia.
Department of Infectious Diseases, Monash University and Alfred Hospital, Melbourne, VIC, Australia.

Adam K Wheatley (AK)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, VIC, Australia.

Stephen J Kent (SJ)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, VIC, Australia.
Melbourne Sexual Health Centre, Infectious Diseases Department, Alfred Health, Central Clinical School, Monash University, Melbourne, VIC, Australia.

Kanta Subbarao (K)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
World Health Organization Collaborating Centre for Reference and Research on Influenza at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

James McMahon (J)

Monash Infectious Diseases, Monash Medical Centre, Monash Health, Melbourne, VIC, Australia.
Department of Infectious Diseases, Monash University and Alfred Hospital, Melbourne, VIC, Australia.

Irani Thevarajan (I)

Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Victorian Infectious Diseases Services, Royal Melbourne Hospital and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne VIC, Australia.

Thi H O Nguyen (THO)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Allen C Cheng (AC)

School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC, Australia.

Katherine Kedzierska (K)

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan.

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Classifications MeSH

questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Integrated immune dynamics define correlates...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Integrated immune dynamics define correlates...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Integrated immune dynamics define correlates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Integrated immune dynamics define correlates...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité active › Production d'anticorps › Integrated immune dynamics define correlates...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Integrated immune dynamics define correlates...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Integrated immune dynamics define correlates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Integrated immune dynamics define correlates...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Integrated immune dynamics define correlates...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-18 › Integrated immune dynamics define correlates...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Integrated immune dynamics define correlates...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Integrated immune dynamics define correlates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › Récepteurs CXCR › Récepteurs CXCR3 › Integrated immune dynamics define correlates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-6 › Integrated immune dynamics define correlates...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Integrated immune dynamics define correlates...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Integrated immune dynamics define correlates...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › Integrated immune dynamics define correlates...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Integrated immune dynamics define correlates...