Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19.
Antioxidants
/ metabolism
Biomarkers
/ metabolism
Brassica
COVID-19
/ complications
COVID-19 Testing
Desensitization, Immunologic
/ methods
Down-Regulation
Humans
NF-E2-Related Factor 2
/ immunology
Nutrients
/ immunology
Oxidative Stress
/ immunology
SARS-CoV-2
/ immunology
Severity of Illness Index
TRPA1 Cation Channel
/ immunology
TRPV Cation Channels
/ immunology
Up-Regulation
Broccoli
COVID-19
Cough challenge
Nrf2
Pungent foods
TRAP-1
Journal
International archives of allergy and immunology
ISSN: 1423-0097
Titre abrégé: Int Arch Allergy Immunol
Pays: Switzerland
ID NLM: 9211652
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
12
2020
accepted:
15
12
2020
pubmed:
11
2
2021
medline:
10
4
2021
entrez:
10
2
2021
Statut:
ppublish
Résumé
In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies.
Identifiants
pubmed: 33567446
pii: 000514204
doi: 10.1159/000514204
pmc: PMC8018185
doi:
Substances chimiques
Antioxidants
0
Biomarkers
0
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
TRPA1 Cation Channel
0
TRPA1 protein, human
0
TRPV Cation Channels
0
TRPV1 protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
324-338Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 S. Karger AG, Basel.
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