Immune Responses and Viral Persistence in Simian/Human Immunodeficiency Virus SHIV.C.CH848-Infected Rhesus Macaques.

Animals Anti-Retroviral Agents / therapeutic use Antibodies, Neutralizing / immunology CD4-Positive T-Lymphocytes / cytology Disease Models, Animal HIV Infections / drug therapy HIV-1 Humans Macaca mulatta Simian Acquired Immunodeficiency Syndrome / drug therapy Simian Immunodeficiency Virus Viral Load / drug effects Viremia / drug therapy
SHIV autologous neutralizing Abs autologous neutralizing Abs and evolution evolution persistent infection viral reservoirs

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
12 04 2021
Historique:
received: 18 11 2020
accepted: 01 02 2021
pubmed: 12 2 2021
medline: 14 5 2021
entrez: 11 2 2021
Statut: epublish

Résumé

Chimeric simian/human immunodeficiency viruses (SHIVs) are widely used in nonhuman primate models to recapitulate human immunodeficiency virus (HIV) infection in humans, yet most SHIVs fail to establish persistent viral infection. We investigated immunological and virological events in rhesus macaques infected with the newly developed SHIV.C.CH848 (SHIVC) and treated with combined antiretroviral therapy (cART). Similar to HIV/simian immunodeficiency virus (SIV) infection, SHIV.C.CH848 infection established viral reservoirs in CD4

Identifiants

DOI: 10.1128/JVI.02198-20 PMID: 33568508 PMC: PMC8104099
pubmed: 33568508
pii: JVI.02198-20
doi: 10.1128/JVI.02198-20
pmc: PMC8104099
pii:
doi:

Substances chimiques

Anti-Retroviral Agents 0
Antibodies, Neutralizing 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD099857
Pays : United States
Organisme : NIAID NIH HHS
ID : R61 AI161818
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI147372
Pays : United States
Organisme : NIH HHS
ID : P51 OD011104
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI114380
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI099795
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI160607
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131251
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI165080
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118549
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE025432
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI122953
Pays : United States

Informations de copyright

Copyright © 2021 Ziani et al.

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Auteurs

Widade Ziani (W)

Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, USA.

Anya Bauer (A)

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
ORCID: 0000-0002-5793-0079

Hong Lu (H)

Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

Xiaolei Wang (X)

Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, USA.

Xueling Wu (X)

Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

Katharine J Bar (KJ)

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Hui Li (H)

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Dongfang Liu (D)

Department of Pathology, Immunology and Laboratory Medicine, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA.

George M Shaw (GM)

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Ronald S Veazey (RS)

Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, USA.

Huanbin Xu (H)

Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, USA hxu@tulane.edu.
ORCID: 0000-0003-1742-0979

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Immune Responses and Viral Persistence in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Immune Responses and Viral Persistence in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Immune Responses and Viral Persistence in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Immune Responses and Viral Persistence in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Immune Responses and Viral Persistence in...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Immune Responses and Viral Persistence in...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Immune Responses and Viral Persistence in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immune Responses and Viral Persistence in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Immune Responses and Viral Persistence in...
questionsmedicales.fr › Maladies de l'animal › Maladies des primates › Maladies des singes › Syndrome d'immunodéficience acquise du singe › Immune Responses and Viral Persistence in...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Rétrovirus simiens › Virus de l'immunodéficience simienne › Immune Responses and Viral Persistence in...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › Immune Responses and Viral Persistence in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Virémie › Immune Responses and Viral Persistence in...