Nicotinamide for the treatment of heart failure with preserved ejection fraction.


Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
10 02 2021
Historique:
received: 18 07 2020
revised: 05 11 2020
accepted: 12 01 2021
entrez: 11 2 2021
pubmed: 12 2 2021
medline: 13 7 2021
Statut: ppublish

Résumé

Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD

Identifiants

pubmed: 33568522
pii: 13/580/eabd7064
doi: 10.1126/scitranslmed.abd7064
pmc: PMC7611499
mid: EMS132462
pii:
doi:

Substances chimiques

Niacinamide 25X51I8RD4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Austrian Science Fund FWF
ID : I 3165
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : I 3301
Pays : Austria

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Mahmoud Abdellatif (M)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.

Viktoria Trummer-Herbst (V)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.

Franziska Koser (F)

Institute of Physiology II, University of Münster, Münster 48149, Germany.

Sylvère Durand (S)

Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif 94805, France.
Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris 75006, France.

Rui Adão (R)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.
Department of Surgery and Physiology, Cardiovascular Research and Development Centre (UnIC), Faculty of Medicine, University of Porto, Porto 4200-319, Portugal.

Francisco Vasques-Nóvoa (F)

Department of Surgery and Physiology, Cardiovascular Research and Development Centre (UnIC), Faculty of Medicine, University of Porto, Porto 4200-319, Portugal.

Johanna K Freundt (JK)

Institute of Physiology II, University of Münster, Münster 48149, Germany.

Julia Voglhuber (J)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.
BioTechMed Graz, Graz 8010, Austria.

Maria-Rosaria Pricolo (MR)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain.

Michael Kasa (M)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.

Clara Türk (C)

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Cologne 50931, Germany.
Center for Molecular Medicine (CMMC), University of Cologne, Cologne 50931, Germany.

Fanny Aprahamian (F)

Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif 94805, France.
Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris 75006, France.

Elías Herrero-Galán (E)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain.

Sebastian J Hofer (SJ)

Institute of Molecular Biosciences, University of Graz, NAWI Graz, Graz 8010, Austria.

Tobias Pendl (T)

Institute of Molecular Biosciences, University of Graz, NAWI Graz, Graz 8010, Austria.

Lavinia Rech (L)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.

Julia Kargl (J)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz 8010, Austria.

Nathaly Anto-Michel (N)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.

Senka Ljubojevic-Holzer (S)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.
BioTechMed Graz, Graz 8010, Austria.

Julia Schipke (J)

Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover 30625, Germany.

Christina Brandenberger (C)

Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover 30625, Germany.

Martina Auer (M)

Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz 8010, Austria.
Division of Cell Biology, Histology and Embryology, Medical University of Graz, Graz 8010, Austria.

Renate Schreiber (R)

Institute of Molecular Biosciences, University of Graz, NAWI Graz, Graz 8010, Austria.

Chintan N Koyani (CN)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.

Akos Heinemann (A)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz 8010, Austria.

Andreas Zirlik (A)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.

Albrecht Schmidt (A)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.

Dirk von Lewinski (D)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.

Daniel Scherr (D)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.

Peter P Rainer (PP)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria.
BioTechMed Graz, Graz 8010, Austria.

Julia von Maltzahn (J)

Leibniz Institute on Aging, Jena 07745, Germany.

Christian Mühlfeld (C)

Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover 30625, Germany.

Marcus Krüger (M)

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Cologne 50931, Germany.
Center for Molecular Medicine (CMMC), University of Cologne, Cologne 50931, Germany.

Saša Frank (S)

BioTechMed Graz, Graz 8010, Austria.
Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz 8010, Austria.

Frank Madeo (F)

BioTechMed Graz, Graz 8010, Austria.
Institute of Molecular Biosciences, University of Graz, NAWI Graz, Graz 8010, Austria.

Tobias Eisenberg (T)

BioTechMed Graz, Graz 8010, Austria.
Institute of Molecular Biosciences, University of Graz, NAWI Graz, Graz 8010, Austria.

Andreas Prokesch (A)

BioTechMed Graz, Graz 8010, Austria.
Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz 8010, Austria.
Division of Cell Biology, Histology and Embryology, Medical University of Graz, Graz 8010, Austria.

Adelino F Leite-Moreira (AF)

Department of Surgery and Physiology, Cardiovascular Research and Development Centre (UnIC), Faculty of Medicine, University of Porto, Porto 4200-319, Portugal.

André P Lourenço (AP)

Department of Surgery and Physiology, Cardiovascular Research and Development Centre (UnIC), Faculty of Medicine, University of Porto, Porto 4200-319, Portugal.

Jorge Alegre-Cebollada (J)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain.

Stefan Kiechl (S)

Department of Neurology, Medical University of Innsbruck, Innsbruck 6020, Austria.
VASCage, Research Centre for Promoting Vascular Health in the Ageing Community, Innsbruck 6020, Austria.

Wolfgang A Linke (WA)

Institute of Physiology II, University of Münster, Münster 48149, Germany.

Guido Kroemer (G)

Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif 94805, France. simon.sedej@medunigraz.at kroemer@orange.fr.
Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris 75006, France.
Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris 75015, France.
Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou 215000, China.
Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Solna 17164, Sweden.

Simon Sedej (S)

Department of Cardiology, Medical University of Graz, Graz 8036, Austria. simon.sedej@medunigraz.at kroemer@orange.fr.
BioTechMed Graz, Graz 8010, Austria.
Faculty of Medicine, University of Maribor, Maribor 2000, Slovenia.

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