Co-culturing multicellular tumor models: Modeling the tumor microenvironment and analysis techniques.
cancer
co-culture
mass spectrometry
spheroids
tumor microenvironment
Journal
Proteomics
ISSN: 1615-9861
Titre abrégé: Proteomics
Pays: Germany
ID NLM: 101092707
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
19
12
2020
received:
15
08
2020
accepted:
13
01
2021
pubmed:
12
2
2021
medline:
18
9
2021
entrez:
11
2
2021
Statut:
ppublish
Résumé
Advances in two-dimensional (2D) and three-dimensional (3D) cell culture over the last 10 years have led to the development of a plethora of methods for cultivating tumor models. More recently, cellular co-cultures have become a suitable testbed. The first portion of this review focuses on co-culturing methods that have been developed in recent years utilizing the multicellular tumor spheroid model. The latter portion describes techniques that are used to analyze the proteomes of mono- or co-cultured tumor models, with a focus on mass spectrometry (MS)-based analyses. Protein profiles are important indicators of the tumor heterogeneity. Therefore, there is a specific focus within this review on analysis by MS and MS imaging methods evaluating the proteomic profiles of 2D and 3D co-cultures. While these models are incredibly important for biological research, so far, they have not been widely explored on the proteomic level. With this review, we aim to introduce these systems to an analytical audience, with the goal of highlighting MS as an underutilized tool for proteomic analysis of tumor models.
Identifiants
pubmed: 33569922
doi: 10.1002/pmic.202000103
pmc: PMC8262778
mid: NIHMS1715769
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000103Subventions
Organisme : NCI NIH HHS
ID : P30 CA016058
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM110406
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM141955
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01-GM110406
Pays : United States
Informations de copyright
© 2021 Wiley-VCH GmbH.
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