Amanda B Hummon

Affiliations

Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, United States.

ORCID: 0000-0002-1969-9013

Publications (37)

Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis.

Journal of medicinal chemistry

Avec: Patrick G Dougherty , Jack H Wellmerling , Amritendu Koley , Jessica K Lukowski , Amanda B Hummon , Estelle Cormet-Boyaka , Dehua Pei

MS imaging of multicellular tumor spheroids and organoids as an emerging tool for personalized medicine and drug discovery.

The Journal of biological chemistry

Avec: Yijia Wang , Amanda B Hummon

Lipidomic comparison of 2D and 3D colon cancer cell culture models.

Journal of mass spectrometry : JMS

Avec: Fernando Tobias , Amanda B Hummon

Tracking Drugs and Lipids: Quantitative Mass Spectrometry Imaging of Liposomal Doxorubicin Delivery and Bilayer Fate in Three-Dimensional Tumor Models.

Analytical chemistry

Avec: Arbil Lopez , Joseph H Holbrook , Gabrielle E Kemper , Jessica K Lukowski , William T Andrews , Amanda B Hummon

Single Cell MALDI-MSI Analysis of Lipids and Proteins within a Replicative Senescence Fibroblast Model.

Journal of the American Society for Mass Spectrometry

Avec: Emily R Sekera , Lorena Rosas , Joseph H Holbrook , Quetzalli D Angeles-Lopez , Timur Khaliullin , Mauricio Rojas , Ana L Mora , Amanda B Hummon

Electroblotting through a tryptic membrane for LC-MS/MS analysis of proteins separated in electrophoretic gels.

The Analyst

Avec: A N Bickner , M M Champion , A B Hummon , M L Bruening

Proteomics of Colorectal Cancer: Tumors, Organoids, and Cell Cultures-A Minireview.

Frontiers in molecular biosciences

Avec: Philip H Lindhorst , Amanda B Hummon

Quantification of Irinotecan in Single Spheroids Using Internal Standards by MALDI Mass Spectrometry Imaging.

Analytical chemistry

Avec: Yijia Wang , Amanda B Hummon

Quantitative mass spectrometry imaging: therapeutics & biomolecules.

Chemical communications (Cambridge, England)

Avec: Joseph H Holbrook , Gabrielle E Kemper , Amanda B Hummon

Lipidomics Profiling Reveals Differential Alterations after FAS Inhibition in 3D Colon Cancer Cell Culture Models.

Journal of proteome research

Avec: Brian D Fries , Fernando Tobias , Yijia Wang , Joseph H Holbrook , Amanda B Hummon

Mass Spectrometry Imaging and Histology for the Analysis of Budding Intestinal Organoids.

Analytical chemistry

Avec: Emily R Sekera , Kubra B Akkaya-Colak , Arbil Lopez , Maria M Mihaylova , Amanda B Hummon

Mass spectrometric investigations of caloric restriction mimetics.

Proteomics

Avec: Michael J Bibyk , Melanie J Campbell , Amanda B Hummon

Co-culturing multicellular tumor models: Modeling the tumor microenvironment and analysis techniques.

Proteomics

Avec: Ariana E Shannon , Claire E Boos , Amanda B Hummon

Advances in stable isotope labeling: dynamic labeling for spatial and temporal proteomic analysis.

Molecular omics

Avec: Nicole C Beller , Amanda B Hummon

Spatial Stable Isotopic Labeling by Amino Acids in Cell Culture: Pulse-Chase Labeling of Three-Dimensional Multicellular Spheroids for Global Proteome Analysis.

Analytical chemistry

Avec: Nicole C Beller , Jessica K Lukowski , Katelyn R Ludwig , Amanda B Hummon

Gas-Phase Fractionation Data-Independent Acquisition Analysis of 3D Cocultured Spheroid Tumor Model Reveals Altered Translational Processes and Signaling Using Proteomics.

Journal of proteome research

Avec: Ariana E Shannon , Claire E Boos , Brian C Searle , Amanda B Hummon

FAS Inhibited Proteomics and Phosphoproteomics Profiling of Colorectal Cancer Spheroids Shows Activation of Ferroptotic Death Mechanism.

Journal of proteome research

Avec: Brian D Fries , Amanda B Hummon

Generation of Proteins with Free N-Terminal Cysteine by Aminopeptidases.

Journal of the American Chemical Society

Avec: Jordan P Hempfling , Emily R Sekera , Amar Sarkar , Amanda B Hummon , Dehua Pei

Development of Spheroid-FPOP: An In-Cell Protein Footprinting Method for 3D Tumor Spheroids.

Journal of the American Society for Mass Spectrometry

Avec: Raquel L Shortt , Yijia Wang , Amanda B Hummon , Lisa M Jones

Crystalline Nanoparticles of Water-Soluble Covalent Basket Cages (CBCs) for Encapsulation of Anticancer Drugs.

Angewandte Chemie (International ed. in English)

Avec: Vageesha W Liyana Gunawardana , Carson Ward , Han Wang , Joseph H Holbrook , Emily R Sekera , Honggang Cui , Amanda B Hummon , Jovica D Badjić

Enhancement of Lipid Signals in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry with Ammonium Fluoride as a Matrix Additive.

Analytical chemistry

Avec: Joseph H Holbrook , Emily R Sekera , Arbil Lopez , Brian D Fries , Fernando Tobias , Kubra Akkaya , Maria M Mihaylova , Amanda B Hummon

Considerations for MALDI-Based Quantitative Mass Spectrometry Imaging Studies.

Journal of proteome research

Avec: Fernando Tobias , Amanda B Hummon

Quantitative evaluation of liposomal doxorubicin and its metabolites in spheroids.

Analytical and bioanalytical chemistry

Avec: Jessica K Lukowski , Amanda B Hummon

Developing a Drug Screening Platform: MALDI-Mass Spectrometry Imaging of Paper-Based Cultures.

Analytical chemistry

Avec: Fernando Tobias , Julie C McIntosh , Gabriel J LaBonia , Matthew W Boyce , Matthew R Lockett , Amanda B Hummon

Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line.

Analytical chemistry

Avec: Daoyang Chen , Katelyn R Ludwig , Oleg V Krokhin , Vic Spicer , Zhichang Yang , Xiaojing Shen , Amanda B Hummon , Liangliang Sun

Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.

Neoplasia (New York, N.Y.)

Avec: Darawalee Wangsa , Rüdiger Braun , Christina H Stuelten , Markus Brown , Kerry M Bauer , Georg Emons , Leigh A Weston , Yue Hu , Howard H Yang , Maria Vila-Casadesús , Maxwell P Lee , Philip Brauer , Lidia Warner , Madhvi Upender , Amanda B Hummon , Jordi Camps , Thomas Ried

A Peptidyl Inhibitor that Blocks Calcineurin-NFAT Interaction and Prevents Acute Lung Injury.

Journal of medicinal chemistry

Avec: Patrick G Dougherty , Manjula Karpurapu , Amritendu Koley , Jessica K Lukowski , Ziqing Qian , Teja Srinivas Nirujogi , Luiza Rusu , Sangwoon Chung , Amanda B Hummon , Hao W Li , John W Christman , Dehua Pei

Electroblotting through Enzymatic Membranes to Enhance Molecular Tissue Imaging.

Journal of the American Society for Mass Spectrometry

Avec: William T Andrews , Adrianna N Bickner , Fernando Tobias , Kendall A Ryan , Merlin L Bruening , Amanda B Hummon

Multi-glycomic analysis of spheroid glycocalyx differentiates 2- and 3-dimensional cell models.

Glycobiology

Avec: Qingwen Zhou , Michael Russelle S Alvarez , Kemal Solakyildirim , Jennyfer Tena , Luster Mae N Serrano , Matthew Lam , Cynthia Nguyen , Fernando Tobias , Amanda B Hummon , Ruel C Nacario , Carlito B Lebrilla

How to Apply Supervised Machine Learning Tools to MS Imaging Files: Case Study with Cancer Spheroids Undergoing Treatment with the Monoclonal Antibody Cetuximab.

Journal of the American Society for Mass Spectrometry

Avec: David Hua , Xin Liu , Eden P Go , Yijia Wang , Amanda B Hummon , Heather Desaire

ColoType: a forty gene signature for consensus molecular subtyping of colorectal cancer tumors using whole-genome assay or targeted RNA-sequencing.

Scientific reports

Avec: Steven A Buechler , Melissa T Stephens , Amanda B Hummon , Katelyn Ludwig , Emily Cannon , Tonia C Carter , Jeffrey Resnick , Yesim Gökmen-Polar , Sunil S Badve

In situ metabolite and lipid analysis of GluN2D

Analytical and bioanalytical chemistry

Avec: William T Andrews , Deborah Donahue , Adam Holmes , Rashna Balsara , Francis J Castellino , Amanda B Hummon

Targeting a xenobiotic transporter to ameliorate vincristine-induced sensory neuropathy.

JCI insight

Avec: Yang Li , Thomas Drabison , Mahesh Nepal , Richard H Ho , Alix F Leblanc , Alice A Gibson , Yan Jin , Wenjian Yang , Kevin M Huang , Muhammad Erfan Uddin , Mingqing Chen , Duncan F DiGiacomo , Xihui Chen , Sobia Razzaq , Jeffrey R Tonniges , Dana M McTigue , Alice S Mims , Maryam B Lustberg , Yijia Wang , Amanda B Hummon , William E Evans , Sharyn D Baker , Guido Cavaletti , Alex Sparreboom , Shuiying Hu

Evaluating the Pharmacokinetics and Pharmacodynamics of Chemotherapeutics within a Spatial SILAC-Labeled Spheroid Model System.

Analytical chemistry

Avec: Nicole C Beller , Yijia Wang , Amanda B Hummon

Workflow for Evaluating Normalization Tools for Omics Data Using Supervised and Unsupervised Machine Learning.

Journal of the American Society for Mass Spectrometry

Avec: Aleesa E Chua , Leah D Pfeifer , Emily R Sekera , Amanda B Hummon , Heather Desaire

Deep top-down proteomics revealed significant proteoform-level differences between metastatic and nonmetastatic colorectal cancer cells.

Science advances

Avec: Elijah N McCool , Tian Xu , Wenrong Chen , Nicole C Beller , Scott M Nolan , Amanda B Hummon , Xiaowen Liu , Liangliang Sun

Single Cell MALDI-MS Imaging of Lipids and Proteins in Senescent Fibroblasts.

bioRxiv : the preprint server for biology

Avec: Emily R Sekera , Lorena Rosas , Joseph H Holbrook , Quetzalli D Angeles , Timur Khaliullin , Mauricio Rojas , Ana L Mora , Amanda B Hummon

Réseau de co-auteurs

Yijia Wang 7 collaborations

Fernando Tobias 7 collaborations

Joseph H Holbrook 7 collaborations

Emily R Sekera 7 collaborations

Jessica K Lukowski 5 collaborations

Nicole C Beller 4 collaborations

Dehua Pei 3 collaborations

Arbil Lopez 3 collaborations

William T Andrews 3 collaborations

Brian D Fries 3 collaborations

Patrick G Dougherty 2 collaborations

Amritendu Koley 2 collaborations

Gabrielle E Kemper 2 collaborations

Lorena Rosas 2 collaborations

Timur Khaliullin 2 collaborations

Mauricio Rojas 2 collaborations

Ana L Mora 2 collaborations

Maria M Mihaylova 2 collaborations

Ariana E Shannon 2 collaborations

Claire E Boos 2 collaborations

Katelyn R Ludwig 2 collaborations

Liangliang Sun 2 collaborations

Heather Desaire 2 collaborations

Jack H Wellmerling 1 collaboration

Estelle Cormet-Boyaka 1 collaboration

Quetzalli D Angeles-Lopez 1 collaboration

A N Bickner 1 collaboration

M M Champion 1 collaboration

A B Hummon 1 collaboration

M L Bruening 1 collaboration

Philip H Lindhorst 1 collaboration

Kubra B Akkaya-Colak 1 collaboration

Michael J Bibyk 1 collaboration

Melanie J Campbell 1 collaboration

Brian C Searle 1 collaboration

Jordan P Hempfling 1 collaboration

Amar Sarkar 1 collaboration

Raquel L Shortt 1 collaboration

Lisa M Jones 1 collaboration

Vageesha W Liyana Gunawardana 1 collaboration

Carson Ward 1 collaboration

Han Wang 1 collaboration

Honggang Cui 1 collaboration

Jovica D Badjić 1 collaboration

Kubra Akkaya 1 collaboration

Julie C McIntosh 1 collaboration

Gabriel J LaBonia 1 collaboration

Matthew W Boyce 1 collaboration

Matthew R Lockett 1 collaboration

Daoyang Chen 1 collaboration

Oleg V Krokhin 1 collaboration

Vic Spicer 1 collaboration

Zhichang Yang 1 collaboration

Xiaojing Shen 1 collaboration

Darawalee Wangsa 1 collaboration

Rüdiger Braun 1 collaboration

Christina H Stuelten 1 collaboration

Markus Brown 1 collaboration

Kerry M Bauer 1 collaboration

Georg Emons 1 collaboration

Leigh A Weston 1 collaboration

Yue Hu 1 collaboration

Howard H Yang 1 collaboration

Maria Vila-Casadesús 1 collaboration

Maxwell P Lee 1 collaboration

Philip Brauer 1 collaboration

Lidia Warner 1 collaboration

Madhvi Upender 1 collaboration

Jordi Camps 1 collaboration

Thomas Ried 1 collaboration

Manjula Karpurapu 1 collaboration

Ziqing Qian 1 collaboration

Teja Srinivas Nirujogi 1 collaboration

Luiza Rusu 1 collaboration

Sangwoon Chung 1 collaboration

Hao W Li 1 collaboration

John W Christman 1 collaboration

Adrianna N Bickner 1 collaboration

Kendall A Ryan 1 collaboration

Merlin L Bruening 1 collaboration

Qingwen Zhou 1 collaboration

Michael Russelle S Alvarez 1 collaboration

Kemal Solakyildirim 1 collaboration

Jennyfer Tena 1 collaboration

Luster Mae N Serrano 1 collaboration

Matthew Lam 1 collaboration

Cynthia Nguyen 1 collaboration

Ruel C Nacario 1 collaboration

Carlito B Lebrilla 1 collaboration

David Hua 1 collaboration

Xin Liu 1 collaboration

Eden P Go 1 collaboration

Steven A Buechler 1 collaboration

Melissa T Stephens 1 collaboration

Katelyn Ludwig 1 collaboration

Emily Cannon 1 collaboration

Tonia C Carter 1 collaboration

Jeffrey Resnick 1 collaboration

Yesim Gökmen-Polar 1 collaboration

Sunil S Badve 1 collaboration

Deborah Donahue 1 collaboration

Adam Holmes 1 collaboration

Rashna Balsara 1 collaboration

Francis J Castellino 1 collaboration

Yang Li 1 collaboration

Thomas Drabison 1 collaboration

Mahesh Nepal 1 collaboration

Richard H Ho 1 collaboration

Alix F Leblanc 1 collaboration

Alice A Gibson 1 collaboration

Yan Jin 1 collaboration

Wenjian Yang 1 collaboration

Kevin M Huang 1 collaboration

Muhammad Erfan Uddin 1 collaboration

Mingqing Chen 1 collaboration

Duncan F DiGiacomo 1 collaboration

Xihui Chen 1 collaboration

Sobia Razzaq 1 collaboration

Jeffrey R Tonniges 1 collaboration

Dana M McTigue 1 collaboration

Alice S Mims 1 collaboration

Maryam B Lustberg 1 collaboration

William E Evans 1 collaboration

Sharyn D Baker 1 collaboration

Guido Cavaletti 1 collaboration

Alex Sparreboom 1 collaboration

Shuiying Hu 1 collaboration

Aleesa E Chua 1 collaboration

Leah D Pfeifer 1 collaboration

Elijah N McCool 1 collaboration

Tian Xu 1 collaboration

Wenrong Chen 1 collaboration

Scott M Nolan 1 collaboration

Xiaowen Liu 1 collaboration

Quetzalli D Angeles 1 collaboration