Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.
ENIGMA
brain morphometry
longitudinal trajectories
multisite
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
27
11
2020
received:
22
06
2020
accepted:
06
12
2020
pubmed:
12
2
2021
medline:
29
3
2022
entrez:
11
2
2021
Statut:
ppublish
Résumé
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
Identifiants
pubmed: 33570244
doi: 10.1002/hbm.25320
pmc: PMC8675429
doi:
Types de publication
Journal Article
Meta-Analysis
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
452-469Subventions
Organisme : NIA NIH HHS
ID : R01 AG058854
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010133
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117014
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG068057
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH104284
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH129742
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH117014
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000153
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072976
Pays : United States
Organisme : NCRR NIH HHS
ID : U24 RR025736
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG019771
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025761
Pays : United States
Organisme : NIMH NIH HHS
ID : MH104284
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIH HHS
ID : P30 AG10133
Pays : United States
Organisme : NIH HHS
ID : 1 U24 RR021992
Pays : United States
Organisme : NIMH NIH HHS
ID : MH116147
Pays : United States
Organisme : European Research Council
Pays : International
Organisme : NICHD NIH HHS
ID : RO1HD050735
Pays : United States
Organisme : NIH HHS
ID : UL1 TR000153
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113619
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH120080
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17209
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01MH113619
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD050735
Pays : United States
Organisme : Medical Research Council
ID : G0500092
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR001414
Pays : United States
Organisme : NCRR NIH HHS
ID : U24 RR021992
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH042191
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH042191
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060610
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA101318
Pays : United States
Organisme : NIH HHS
ID : R01 AG19771
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119219
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH090553
Pays : United States
Organisme : NIH HHS
ID : 1 U24 RR025736-01
Pays : United States
Organisme : NIDA NIH HHS
ID : RC2 DA029475
Pays : United States
Informations de copyright
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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