COVID-19 and developmental origins of health and disease.


Journal

Early human development
ISSN: 1872-6232
Titre abrégé: Early Hum Dev
Pays: Ireland
ID NLM: 7708381

Informations de publication

Date de publication:
04 2021
Historique:
received: 31 08 2020
revised: 14 01 2021
accepted: 17 01 2021
pubmed: 12 2 2021
medline: 15 4 2021
entrez: 11 2 2021
Statut: ppublish

Résumé

From the moment of the identification of SARS-CoV-2 as an etiological agent of the severe clinical pictures of pneumonia that were being slowly observed all over the world, numerous studies have been conducted to increase the knowledge about what was an unknown virus until then. The efforts were mainly aimed to acquire epidemiological, microbiological, pathogenetic, clinical, diagnostic, therapeutic and preventive information in order to increase the available weapons to fight an infection which was rapidly taking on the characteristics of the pandemic. Given the topicality of the problem, not everything has yet been fully understood and clarified, especially in the maternal-fetal‑neonatal field, where we are beginning to question what could be the outcomes of newborn babies born to mothers who contracted SARS-CoV-2 infection during pregnancy. Thus, the aim of this review is to analyze the long-term outcomes of this infection that could affect the offspring, regardless of a possible maternal-fetal transmission, focusing on, above all, the role of maternal immune activation and the expression of the Angiotensin-converting enzyme 2 (ACE2) in particular at the placental level.

Identifiants

pubmed: 33571742
pii: S0378-3782(21)00018-9
doi: 10.1016/j.earlhumdev.2021.105322
pmc: PMC7837628
pii:
doi:

Substances chimiques

ACE2 protein, human EC 3.4.17.23
Angiotensin-Converting Enzyme 2 EC 3.4.17.23

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

105322

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

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Auteurs

Stefano Forestieri (S)

School of Pediatrics, University of Cagliari, Cagliari, Italy.

Roberta Pintus (R)

Department of Surgery, Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Italy. Electronic address: gomberta@icloud.com.

Maria Antonietta Marcialis (MA)

Neonatal Intensive Care Unit, AOU, Cagliari, Cagliari, Italy.

Maria Cristina Pintus (MC)

Neonatal Intensive Care Unit, AOU, Cagliari, Cagliari, Italy.

Vassilios Fanos (V)

Department of Surgery, Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Italy; Neonatal Intensive Care Unit, AOU, Cagliari, Cagliari, Italy.

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Classifications MeSH