Dibenzodiazepinone-type muscarinic receptor antagonists conjugated to basic peptides: Impact of the linker moiety and unnatural amino acids on M
Amino Acids
/ antagonists & inhibitors
Animals
Benzodiazepinones
/ chemical synthesis
Cells, Cultured
Dose-Response Relationship, Drug
Humans
Molecular Docking Simulation
Molecular Structure
Muscarinic Antagonists
/ chemical synthesis
Peptides
/ chemistry
Receptor, Muscarinic M2
/ antagonists & inhibitors
Structure-Activity Relationship
Basic amino acid
Dibenzodiazepinone derivative
Induced-fit docking
M2R antagonist
M2R selectivity
MR subtype selectivity
Muscarinic acetylcholine receptors
Peptide
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
05 Mar 2021
05 Mar 2021
Historique:
received:
28
10
2020
revised:
03
01
2021
accepted:
04
01
2021
pubmed:
12
2
2021
medline:
1
5
2021
entrez:
11
2
2021
Statut:
ppublish
Résumé
The family of human muscarinic acetylcholine receptors (MRs) is characterized by a high sequence homology among the five subtypes (M
Identifiants
pubmed: 33571911
pii: S0223-5234(21)00008-8
doi: 10.1016/j.ejmech.2021.113159
pii:
doi:
Substances chimiques
Amino Acids
0
Benzodiazepinones
0
Muscarinic Antagonists
0
Peptides
0
Receptor, Muscarinic M2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113159Informations de copyright
Copyright © 2021 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.