Hyperbaric Oxygen Preconditioning Upregulates Heme OxyGenase-1 and Anti-Apoptotic Bcl-2 Protein Expression in Spontaneously Hypertensive Rats with Induced Postischemic Acute Kidney Injury.
Acute Kidney Injury
/ etiology
Animals
Creatinine
/ metabolism
Disease Models, Animal
Heme Oxygenase (Decyclizing)
/ metabolism
Humans
Hyperbaric Oxygenation
/ methods
Hypertension
/ complications
Kidney
/ blood supply
Male
Oxygen
/ administration & dosage
Phosphates
/ metabolism
Proto-Oncogene Proteins c-bcl-2
/ metabolism
Rats
Rats, Inbred SHR
Rats, Wistar
Renal Elimination
/ physiology
Reperfusion Injury
/ etiology
Up-Regulation
Urea
/ metabolism
Bcl-2
Wistar rats
acute kidney injury
heme oxygenase-1, Bax
hyperbaric oxygen preconditioning
spontaneously hypertensive rats
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Jan 2021
30 Jan 2021
Historique:
received:
31
12
2020
revised:
22
01
2021
accepted:
23
01
2021
entrez:
12
2
2021
pubmed:
13
2
2021
medline:
8
9
2021
Statut:
epublish
Résumé
Renal ischemia and reperfusion (I/R) injury is the most common cause of acute kidney injury (AKI). Pathogenesis of postischemic AKI involves hemodynamic changes, oxidative stress, inflammation process, calcium ion overloading, apoptosis and necrosis. Up to date, therapeutic approaches to treat AKI are extremely limited. Thus, the aim of this study was to evaluate the effects of hyperbaric oxygen (HBO) preconditioning on citoprotective enzyme, heme oxygenase-1 (HO-1), pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins expression, in postischemic AKI induced in normotensive Wistar and spontaneously hypertensive rats (SHR). The animals were randomly divided into six experimental groups: SHAM-operated Wistar rats (W-SHAM), Wistar rats with induced postischemic AKI (W-AKI) and Wistar group with HBO preconditioning before AKI induction (W-AKI + HBO). On the other hand, SHR rats were also divided into same three groups: SHR-SHAM, SHR-AKI and SHR-AKI + HBO. We demonstrated that HBO preconditioning upregulated HO-1 and anti-apoptotic Bcl-2 protein expression, in both Wistar and SH rats. In addition, HBO preconditioning improved glomerular filtration rate, supporting by significant increase in creatinine, urea and phosphate clearances in both rat strains. Considering our results, we can also say that even in hypertensive conditions, we can expect protective effects of HBO preconditioning in experimental model of AKI.
Identifiants
pubmed: 33573145
pii: ijms22031382
doi: 10.3390/ijms22031382
pmc: PMC7866496
pii:
doi:
Substances chimiques
Bcl2 protein, rat
0
Phosphates
0
Proto-Oncogene Proteins c-bcl-2
0
Urea
8W8T17847W
Creatinine
AYI8EX34EU
Heme Oxygenase (Decyclizing)
EC 1.14.14.18
Hmox1 protein, rat
EC 1.14.14.18
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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