Chronic antipsychotic treatment exerts limited effects on the mania-like behavior of dopamine transporter knockdown mice.
Animals
Antipsychotic Agents
/ administration & dosage
Behavior, Animal
/ drug effects
Bipolar Disorder
/ drug therapy
Dibenzocycloheptenes
/ pharmacology
Disease Models, Animal
Dopamine D2 Receptor Antagonists
/ administration & dosage
Dopamine Plasma Membrane Transport Proteins
/ deficiency
Female
Male
Mania
/ drug therapy
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Transgenic
Risperidone
/ pharmacology
Antipsychotic
Behavioral pattern monitor
Bipolar disorder
Dopamine transporter
Mania
Mice
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
07 05 2021
07 05 2021
Historique:
received:
27
08
2020
revised:
02
02
2021
accepted:
03
02
2021
pubmed:
13
2
2021
medline:
27
1
2022
entrez:
12
2
2021
Statut:
ppublish
Résumé
Bipolar disorder is a life-threatening disorder linked to dopamine transporter (DAT) polymorphisms, with reduced DAT levels seen in positron emission tomography and postmortem brains. The purpose of this study was to examine the effects of approved antipsychotics on DAT dysfunction-mediated mania behavior in mice. DAT knockdown mice received either D Chronic risperidone did not reverse mania-like behavior in DAT knockdown mice. Chronic asenapine reduced mania behavior but this effect was more pronounced in wild-type littermates than in DAT knockdown mice. Taken together, these findings suggest that while acute antipsychotic treatment may be beneficial in management of bipolar mania, more targeted therapeutics may be necessary for long-term treatment. Specific investigation into DAT-targeting drugs could improve future treatment of bipolar mania.
Sections du résumé
BACKGROUND
Bipolar disorder is a life-threatening disorder linked to dopamine transporter (DAT) polymorphisms, with reduced DAT levels seen in positron emission tomography and postmortem brains.
AIMS
The purpose of this study was to examine the effects of approved antipsychotics on DAT dysfunction-mediated mania behavior in mice.
METHODS
DAT knockdown mice received either D
RESULTS
Chronic risperidone did not reverse mania-like behavior in DAT knockdown mice. Chronic asenapine reduced mania behavior but this effect was more pronounced in wild-type littermates than in DAT knockdown mice.
CONCLUSION
Taken together, these findings suggest that while acute antipsychotic treatment may be beneficial in management of bipolar mania, more targeted therapeutics may be necessary for long-term treatment. Specific investigation into DAT-targeting drugs could improve future treatment of bipolar mania.
Identifiants
pubmed: 33577882
pii: S0166-4328(21)00054-1
doi: 10.1016/j.bbr.2021.113167
pii:
doi:
Substances chimiques
Antipsychotic Agents
0
Dibenzocycloheptenes
0
Dopamine D2 Receptor Antagonists
0
Dopamine Plasma Membrane Transport Proteins
0
asenapine
JKZ19V908O
Risperidone
L6UH7ZF8HC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113167Subventions
Organisme : NIDA NIH HHS
ID : R01 DA043535
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier B.V.