EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction.
Apoptosis
/ drug effects
Binding Sites
Catechin
/ analogs & derivatives
Cell Line, Tumor
Epitopes
Humans
Protein Binding
Proto-Oncogene Proteins c-mdm2
/ chemistry
Scattering, Small Angle
Tea
Tumor Suppressor Protein p53
/ chemistry
Ubiquitin-Protein Ligases
/ metabolism
Ubiquitination
X-Ray Diffraction
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
12 02 2021
12 02 2021
Historique:
received:
23
05
2020
accepted:
11
01
2021
entrez:
13
2
2021
pubmed:
14
2
2021
medline:
3
3
2021
Statut:
epublish
Résumé
Epigallocatechin gallate (EGCG) from green tea can induce apoptosis in cancerous cells, but the underlying molecular mechanisms remain poorly understood. Using SPR and NMR, here we report a direct, μM interaction between EGCG and the tumor suppressor p53 (K
Identifiants
pubmed: 33579943
doi: 10.1038/s41467-021-21258-5
pii: 10.1038/s41467-021-21258-5
pmc: PMC7881117
doi:
Substances chimiques
Epitopes
0
TP53 protein, human
0
Tea
0
Tumor Suppressor Protein p53
0
Catechin
8R1V1STN48
epigallocatechin gallate
BQM438CTEL
MDM2 protein, human
EC 2.3.2.27
Proto-Oncogene Proteins c-mdm2
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
986Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM114300
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM128119
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM127040
Pays : United States
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