Expression and cellular distribution of FGF13 in cortical tubers of the tuberous sclerosis complex.
Cortical tubers
Fibroblast growth factors 13
Intractable epilepsy
Tuberous sclerosis complex
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
19
08
2020
revised:
14
01
2021
accepted:
03
02
2021
pubmed:
15
2
2021
medline:
4
6
2021
entrez:
14
2
2021
Statut:
ppublish
Résumé
Cortical tubers in patients with tuberous sclerosis complex (TSC) are highly associated with intractable epilepsy. Recent evidence suggests a close relationship between FGF13 and seizures. To understand the role of FGF13 in the pathogenesis of cortical tubers, we investigated the expression pattern of FGF13 in cortical tubers of TSC compared with normal control cortices (CTX). We found that both the mRNA and protein levels of FGF13 were significantly higher in the cortical tubers from patients with TSC than in the control cortices. The immunohistochemical results showed strong FGF13 immunoreactivity in abnormal cells, including dysplastic neurons (DNs) and giant cells (GCs). Moreover, double-label immunofluorescence analyses confirmed that FGF13 was mainly localized in neurons and nearly absent in glia-like cells. The protein levels of FGF13 in the TSC samples were positively correlated with the frequency of seizures before surgery. Taken together, these results suggest that the overexpression and distribution pattern of FGF13 may be related to intractable epilepsy caused by TSC.
Identifiants
pubmed: 33582188
pii: S0304-3940(21)00092-6
doi: 10.1016/j.neulet.2021.135714
pii:
doi:
Substances chimiques
fibroblast growth factor 13
330E71H5Q4
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
135714Informations de copyright
Copyright © 2021. Published by Elsevier B.V.