A Longitudinal Pilot Study on Cognition and Cerebral Hemodynamics in a Mouse Model of Preeclampsia Superimposed on Hypertension: Looking at Mothers and Their Offspring.
cerebral hemodynamics
cerebrovascular function
cognition
preeclampsia
renin—angiotensin—aldosterone system
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
09
2020
accepted:
06
01
2021
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
16
2
2021
Statut:
epublish
Résumé
Preeclampsia is a common hypertensive disorder in pregnant women and whose causes and consequences have focused primarily on cardiovascular outcomes on the mother and offspring, often without taking into consideration the possible effects on the brain. One possible cause of preeclampsia has been attributed to alterations in the renin-angiotensin system, which has also been linked to cognitive decline. In this pilot study, we use a transgenic mouse model that chronically overexpresses human angiotensinogen and renin (R
Identifiants
pubmed: 33584345
doi: 10.3389/fphys.2021.611984
pmc: PMC7878560
doi:
Types de publication
Journal Article
Langues
eng
Pagination
611984Informations de copyright
Copyright © 2021 Trigiani, Lecrux, Royea, Lavoie, Lesage, Pilote and Hamel.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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