Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease.
arrhythmias
cardiac fibroblasts
cardiomyocytes
fibrosis
heart failure
myofibroblast
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
16
2
2021
medline:
15
10
2021
entrez:
15
2
2021
Statut:
ppublish
Résumé
Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance of fibrosis in processes of wound healing, excessive fibroblast proliferation and activation can lead to pathological remodeling, driving heart failure and the onset of arrhythmias. Our understanding of the mechanisms driving the cardiac fibroblast activation and proliferation is expanding, and evidence for their direct and indirect effects on cardiac myocyte function is accumulating. In this review, we focus on the importance of the fibroblast-to-myofibroblast transition and the cross talk of cardiac fibroblasts with cardiac myocytes. We also consider the current use of models used to explore these questions.
Identifiants
pubmed: 33586463
doi: 10.1161/JAHA.120.019338
pmc: PMC8174279
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e019338Subventions
Organisme : British Heart Foundation
ID : FS/19/12/34204
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/K000225/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/12/40/29712
Pays : United Kingdom
Organisme : British Heart Foundation
ID : SP/15/9/31605
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/13/1/30181
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/14/59/31000
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 201543/Z/16/Z
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/C013202/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/14/1/30588
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RM/13/30157
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 109604/Z/15/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 201543/B/16/Z
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/C013105/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/17/15/33106
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/19/16/34169
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/T001747/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : P47352/CRM
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L012618/1
Pays : United Kingdom
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