Exposure to fine particulate matter (PM

Animals Cell Differentiation / physiology Demyelinating Diseases / chemically induced Disease Models, Animal Male Mice Mice, Inbred C57BL Myelin Sheath / pathology Particulate Matter / administration & dosage Trachea / pathology White Matter / pathology
Air pollution Glial reactivity Multiple sclerosis Oligodendrocytes Remyelination

Journal

Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959

Informations de publication

Date de publication:
05 2021
Historique:
received: 28 08 2020
revised: 05 01 2021
accepted: 10 02 2021
pubmed: 16 2 2021
medline: 19 11 2021
entrez: 15 2 2021
Statut: ppublish

Résumé

Epidemiological studies show a strong association between exposure to air pollution - and particularly to particulate matter (PM) -, increased prevalence of Multiple Sclerosis (MS) and higher rates of hospital admissions for MS and MS relapses. Besides having immunomodulatory effects and sustaining a systemic oxidative-inflammatory response, PM may participate in MS pathogenesis by targeting also Central Nervous System (CNS)-specific processes, such as myelin repair. Here we show that, in a mouse model of lysolecithin-induced demyelination of the subcortical white matter, post-injury exposure to fine PM hampers remyelination, disturbs oligodendroglia differentiation dynamics and promotes astroglia and microglia reactivity. These findings support the view that exposure to fine PM can contribute to demyelinating pathologies by targeting the endogenous regenerative capability of the CNS tissue.

Identifiants

DOI: 10.1016/j.neuint.2021.104991 PMID: 33587955
pubmed: 33587955
pii: S0197-0186(21)00037-1
doi: 10.1016/j.neuint.2021.104991
pii:
doi:

Substances chimiques

Particulate Matter 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

104991

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Roberta Parolisi (R)

Department of Neuroscience Rita Levi-Montalcini, University of Turin, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Regione Gonzole, 10, 10043, Orbassano (Turin), Italy.

Francesca Montarolo (F)

Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Regione Gonzole, 10, 10043, Orbassano (Turin), Italy; Neurobiology Unit, Neurology-CReSM (Regional Referring Center of Multiple Sclerosis), AOU San Luigi Gonzaga, Regione Gonzole 10, 10043, Orbassano, Italy; Department of Molecular Biotechnology and Health Sciences, University of Turin, via Nizza 52, 10126, Turin, Italy.

Alessandro Pini (A)

Department of Clinical and Experimental Medicine, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy.

Sabrina Rovelli (S)

Department of Science and High Technology, University of Insubria, 22100, Como, Italy.

Andrea Cattaneo (A)

Department of Science and High Technology, University of Insubria, 22100, Como, Italy.

Antonio Bertolotto (A)

Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Regione Gonzole, 10, 10043, Orbassano (Turin), Italy; Neurobiology Unit, Neurology-CReSM (Regional Referring Center of Multiple Sclerosis), AOU San Luigi Gonzaga, Regione Gonzole 10, 10043, Orbassano, Italy.

Annalisa Buffo (A)

Department of Neuroscience Rita Levi-Montalcini, University of Turin, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Regione Gonzole, 10, 10043, Orbassano (Turin), Italy.

Valentina Bollati (V)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Enrica Boda (E)

Department of Neuroscience Rita Levi-Montalcini, University of Turin, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Regione Gonzole, 10, 10043, Orbassano (Turin), Italy. Electronic address: enrica.boda@unito.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Exposure to fine particulate matter (PM
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Exposure to fine particulate matter (PM
questionsmedicales.fr › Maladies du système nerveux › Maladies démyélinisantes › Exposure to fine particulate matter (PM
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Exposure to fine particulate matter (PM
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Exposure to fine particulate matter (PM
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Exposure to fine particulate matter (PM
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Gaine de myéline › Exposure to fine particulate matter (PM
questionsmedicales.fr › Mélanges complexes › Matière particulaire › Exposure to fine particulate matter (PM
questionsmedicales.fr › Appareil respiratoire › Trachée › Exposure to fine particulate matter (PM
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Exposure to fine particulate matter (PM