A Fusion Transcription Factor-Driven Cancer Progresses to a Fusion-Independent Relapse via Constitutive Activation of a Downstream Transcriptional Target.
Animals
Apoptosis
Biomarkers, Tumor
/ genetics
Cell Movement
Cell Proliferation
Female
Fibroblast Growth Factor 8
/ genetics
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Inbred NOD
Mice, SCID
Neoplasm Recurrence, Local
/ genetics
Oncogene Proteins, Fusion
/ genetics
Paired Box Transcription Factors
/ genetics
Rhabdomyosarcoma
/ genetics
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
received:
21
05
2020
revised:
22
12
2020
accepted:
11
02
2021
pubmed:
17
2
2021
medline:
5
11
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
Targeted monotherapies usually fail due to development of resistance by a subgroup of cells that evolve into recurrent tumors. Alveolar rhabdomyosarcoma is an aggressive myogenic soft-tissue cancer that is associated with a characteristic
Identifiants
pubmed: 33589519
pii: 0008-5472.CAN-20-1613
doi: 10.1158/0008-5472.CAN-20-1613
pmc: PMC8178207
mid: NIHMS1675840
doi:
Substances chimiques
Biomarkers, Tumor
0
FGF8 protein, human
0
Oncogene Proteins, Fusion
0
PAX3-FOXO1A fusion protein, human
0
Paired Box Transcription Factors
0
Fibroblast Growth Factor 8
148997-75-5
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2930-2942Subventions
Organisme : Intramural NIH HHS
ID : Z99 CA999999
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA BC011387
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
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