"The Heidelberg Five" personality dimensions: Genome-wide associations, polygenic risk for neuroticism, and psychopathology 20 years after assessment.
Adult
Aged
Anxiety Disorders
/ epidemiology
Female
Genetic Markers
Genome-Wide Association Study
Genotype
Germany
Humans
Longitudinal Studies
Male
Middle Aged
Mood Disorders
/ epidemiology
Neuroticism
Personality Disorders
/ epidemiology
Phenotype
Polymorphism, Single Nucleotide
Psychopathology
Time Factors
control
executive
longitudinal
psychoticism
Journal
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISSN: 1552-485X
Titre abrégé: Am J Med Genet B Neuropsychiatr Genet
Pays: United States
ID NLM: 101235742
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
16
12
2020
revised:
19
01
2021
accepted:
21
01
2021
pubmed:
17
2
2021
medline:
31
7
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
HeiDE is a longitudinal population-based study that started in the 1990s and, at baseline, assessed an array of health-related personality questionnaires in 5133 individuals. Five latent personality dimensions (The Heidelberg Five) were identified and interpreted as Emotional Lability (ELAB), Lack of Behavioral Control (LBCN), Type A Behavior (TYAB), Locus of Control over Disease (LOCC), and Psychoticism (PSYC). At follow-up, 3268 HeiDE participants (post-QC) were genotyped on single nucleotide polymorphism (SNP) arrays. To further characterize The Heidelberg Five, we analyzed genomic underpinnings, their relations to the genetic basis of the Big Five trait Neuroticism, and longitudinal associations with psychiatric symptoms at follow-up. SNP-based heritability was significant for ELAB (34%) and LBCN (29%). A genome-wide association study for each personality dimension was conducted; only the phenotype PSYC yielded a genome-wide significant finding (p < 5 × 10
Identifiants
pubmed: 33590662
doi: 10.1002/ajmg.b.32837
doi:
Substances chimiques
Genetic Markers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-89Subventions
Organisme : UNC Clinical and Translational Science Award
ID : UL1TR002489
Organisme : NIA NIH HHS
ID : R01 AG056479
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118255
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD011680
Pays : United States
Informations de copyright
© 2021 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.
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