Gait variability across neurodegenerative and cognitive disorders: Results from the Canadian Consortium of Neurodegeneration in Aging (CCNA) and the Gait and Brain Study.
Aged
Aging
/ physiology
Alzheimer Disease
/ physiopathology
Biomarkers
Brain
/ physiopathology
Canada
Cognition Disorders
/ physiopathology
Dementia
/ physiopathology
Frontotemporal Dementia
/ physiopathology
Gait
/ physiology
Humans
Lewy Body Disease
/ physiopathology
Parkinson Disease
/ physiopathology
biomarker
cognition
dementia
gait variability
neurodegenerative diseases
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
27
12
2020
received:
21
10
2020
accepted:
01
01
2021
pubmed:
17
2
2021
medline:
20
11
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
Gait impairment is common in neurodegenerative disorders. Specifically, gait variability-the stride-to-stride fluctuations in distance and time-has been associated with neurodegeneration and cognitive impairment. However, quantitative comparisons of gait impairments across the cognitive spectrum of dementias have not been systematically investigated. Older adults (N = 500) with subjective cognitive impairment, Parkinson disease (PD), mild cognitive impairment (MCI), PD-MCI, Alzheimer's disease (AD), PD-dementia, Lewy body dementia, and frontotemporal dementia, as well cognitive normal controls, who were assessed for their gait and cognitive performance. Factor analyses grouped 11 quantitative gait parameters and identified four independent gait domains: rhythm, pace, variability, and postural control, for group comparisons and classification analysis. Among these domains, only high gait variability was associated with lower cognitive performance and accurately discriminated AD from other neurodegenerative and cognitive conditions. Our findings indicate that high gait variability is a marker of cognitive-cortical dysfunction, which can help to identify Alzheimer's disease dementia.
Identifiants
pubmed: 33590967
doi: 10.1002/alz.12298
pmc: PMC8451764
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1317-1328Subventions
Organisme : CIHR
ID : MOP 211220
Pays : Canada
Organisme : CIHR
ID : PJT 153100
Pays : Canada
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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