Recovery of Contrast Sensitivity After Descemet Membrane Endothelial Keratoplasty.
Aged
Aged, 80 and over
Blister
/ physiopathology
Cell Count
Color Vision
/ physiology
Contrast Sensitivity
/ physiology
Corneal Diseases
/ physiopathology
Corneal Endothelial Cell Loss
/ physiopathology
Corneal Wavefront Aberration
/ physiopathology
Descemet Stripping Endothelial Keratoplasty
Endothelium, Corneal
/ pathology
Female
Fuchs' Endothelial Dystrophy
/ physiopathology
Humans
Male
Mesopic Vision
/ physiology
Postoperative Complications
Postoperative Period
Prospective Studies
Recovery of Function
/ physiology
Journal
Cornea
ISSN: 1536-4798
Titre abrégé: Cornea
Pays: United States
ID NLM: 8216186
Informations de publication
Date de publication:
01 Sep 2021
01 Sep 2021
Historique:
received:
26
06
2020
accepted:
01
01
2021
pubmed:
17
2
2021
medline:
15
12
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
To study the change in contrast sensitivities in eyes with Fuchs endothelial dystrophy and bullous keratopathy after Descemet membrane endothelial keratoplasty (DMEK). In this prospective study, 50 pseudophakic eyes of 50 patients who received DMEK surgery at the Charité-Universitätsmedizin Berlin were included. Visual acuity; contrast sensitivity using OPTEC 6500 at spatial frequencies of 1.5, 3, 6, 12, and 18 cycles/degree in photopic and mesopic light with and without glare; central corneal thickness (CCT); and anterior and posterior corneal aberrations were measured preoperatively and at 3 and 12 months postoperatively. Best-corrected visual acuity (preoperative 0.67 ± 0.46 and after 12 months 0.19 ± 0.16 LogMAR, P < 0.001) and photopic and mesopic contrast sensitivities with and without glare improved significantly, whereas CCT decreased significantly (preoperative 677 ± 114 μm, after 12 months 527 ± 29 μm, P < 0.001). Preoperative CCT correlates significantly with preoperative photopic contrast sensitivity (correlation coefficient -0.462, P = 0.002), and postoperative total anterior aberrations correlates with postoperative photopic contrast sensitivity (correlation coefficient -0.361, P = 0.006). Photopic and mesopic contrast sensitivities, especially with glare, are impaired in patients with Fuchs endothelial dystrophy and bullous keratopathy. The extent of the corneal thickening seems to mainly influence the contrast sensitivity preoperatively. DMEK surgery improves the contrast sensitivity significantly. However, higher postoperative anterior corneal aberrations limit the postoperative contrast sensitivities.
Identifiants
pubmed: 33591041
doi: 10.1097/ICO.0000000000002686
pii: 00003226-202109000-00009
doi:
Banques de données
ClinicalTrials.gov
['NCT02020044']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1110-1116Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors have no funding or conflicts of interest to disclose.
Références
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