Chemical Exchanges between Multilateral Symbionts.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
05 03 2021
05 03 2021
Historique:
pubmed:
17
2
2021
medline:
5
10
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis.
Identifiants
pubmed: 33591189
doi: 10.1021/acs.orglett.1c00068
pmc: PMC8465764
mid: NIHMS1741319
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1648-1652Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM034496
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142720
Pays : United States
Organisme : FIC NIH HHS
ID : U19 TW009872
Pays : United States
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