Jon Clardy

Affiliations

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.

Publications (35)

An elusive electron shuttle from a facultative anaerobe.

eLife

Avec: Emily Mevers , Lin Su , Gleb Pishchany , Moshe Baruch , Jose Cornejo , Elissa Hobert , Eric Dimise , Caroline M Ajo-Franklin , Jon Clardy

GABA-modulating bacteria of the human gut microbiota.

Nature microbiology

Avec: Philip Strandwitz , Ki Hyun Kim , Darya Terekhova , Joanne K Liu , Anukriti Sharma , Jennifer Levering , Daniel McDonald , David Dietrich , Timothy R Ramadhar , Asama Lekbua , Nader Mroue , Conor Liston , Eric J Stewart , Marc J Dubin , Karsten Zengler , Rob Knight , Jack A Gilbert , Jon Clardy , Kim Lewis

Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.

Cell host & microbe

Avec: Lihua Ye , Munhyung Bae , Chelsi D Cassilly , Sairam V Jabba , Daniel W Thorpe , Alyce M Martin , Hsiu-Yi Lu , Jinhu Wang , John D Thompson , Colin R Lickwar , Kenneth D Poss , Damien J Keating , Sven-Eric Jordt , Jon Clardy , Rodger A Liddle , John F Rawls

Bacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine

Marine drugs

Avec: Jia-Xuan Yan , Qihao Wu , Eric J N Helfrich , Marc G Chevrette , Doug R Braun , Heino Heyman , Gene E Ananiev , Scott R Rajski , Cameron R Currie , Jon Clardy , Tim S Bugni

Journal of the American Chemical Society

Avec: Jaeyoung Kwon , Munhyung Bae , Dávid Szamosvári , Chelsi D Cassilly , Andrew S Bolze , David R Jackson , Ramnik J Xavier , Jon Clardy

Discovering functional small molecules in the gut microbiome.

Current opinion in chemical biology

Avec: Mohammad R Seyedsayamdost , Jon Clardy

Biosynthesis of the Unusual Epoxy Isonitrile-Containing Antibiotics Aerocyanidin and Amycomicin.

Journal of the American Chemical Society

Avec: Ziyang Zheng , Jon Clardy , Hung-Wen Liu

A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity.

PLoS pathogens

Avec: Roberta M O'Connor , Felix J Nepveux V , Jaypee Abenoja , Gregory Bowden , Patricia Reis , Josiah Beaushaw , Rachel M Bone Relat , Iwona Driskell , Fernanda Gimenez , Michael W Riggs , Deborah A Schaefer , Eric W Schmidt , Zhenjian Lin , Daniel L Distel , Jon Clardy , Timothy R Ramadhar , David R Allred , Heather M Fritz , Pradipsinh Rathod , Laura Chery , John White

Metabolites Involved in Immune Evasion by

Infection and immunity

Avec: Louise A Rollins-Smith , Antonio C Ruzzini , J Scott Fites , Laura K Reinert , Emily M Hall , Bryan A Joosse , Vishvaas I Ravikumar , Megan I Huebner , Audrey Aka , Miles H Kehs , Bria M Gillard , Emily Doe , Julia A Tasca , Thomas P Umile , Jon Clardy , Kevin P C Minbiole

Cycloheximide-Producing

Frontiers in microbiology

Avec: Kirk J Grubbs , Frank Surup , Peter H W Biedermann , Bradon R McDonald , Jonathan L Klassen , Caitlin M Carlson , Jon Clardy , Cameron R Currie

Specialized Metabolites Reveal Evolutionary History and Geographic Dispersion of a Multilateral Symbiosis.

ACS central science

Avec: Taise T H Fukuda , Eric J N Helfrich , Emily Mevers , Weilan G P Melo , Ethan B Van Arnam , David R Andes , Cameron R Currie , Monica T Pupo , Jon Clardy

Akkermansia muciniphila phospholipid induces homeostatic immune responses.

Nature

Avec: Munhyung Bae , Chelsi D Cassilly , Xiaoxi Liu , Sung-Moo Park , Betsabeh Khoramian Tusi , Xiangjun Chen , Jaeyoung Kwon , Pavel Filipčík , Andrew S Bolze , Zehua Liu , Hera Vlamakis , Daniel B Graham , Sara J Buhrlage , Ramnik J Xavier , Jon Clardy

Gut microbiome lipid metabolism and its impact on host physiology.

Cell host & microbe

Avec: Eric M Brown , Jon Clardy , Ramnik J Xavier

Vaginal lactobacilli produce anti-inflammatory β-carboline compounds.

Cell host & microbe

Avec: Virginia J Glick , Cecilia A Webber , Lauren E Simmons , Morgan C Martin , Maryam Ahmad , Cecilia H Kim , Amanda N D Adams , Sunghee Bang , Michael C Chao , Nicole C Howard , Sarah M Fortune , Manasvi Verma , Marco Jost , Lalit K Beura , Michael J James , Seo Yoon Lee , Caroline M Mitchell , Jon Clardy , Ki Hyun Kim , Smita Gopinath

A conserved coccidian gene is involved in Toxoplasma sensitivity to the anti-apicomplexan compound, tartrolon E.

International journal for parasitology. Drugs and drug resistance

Avec: Gregory D Bowden , Patricia M Reis , Maxwell B Rogers , Rachel M Bone Relat , Kelly A Brayton , Sarah K Wilson , Bruno Martorelli Di Genova , Laura J Knoll , Felix J Nepveux V , Albert K Tai , Timothy R Ramadhar , Jon Clardy , Roberta M O'Connor

Proceedings of the National Academy of Sciences of the United States of America

Avec: Matthew T Henke , Douglas J Kenny , Chelsi D Cassilly , Hera Vlamakis , Ramnik J Xavier , Jon Clardy

Capsular polysaccharide correlates with immune response to the human gut microbe

Proceedings of the National Academy of Sciences of the United States of America

Avec: Matthew T Henke , Eric M Brown , Chelsi D Cassilly , Hera Vlamakis , Ramnik J Xavier , Jon Clardy

Chemical Exchanges between Multilateral Symbionts.

Organic letters

Avec: Munhyung Bae , Emily Mevers , Gleb Pishchany , Sarah G Whaley , Charles O Rock , David R Andes , Cameron R Currie , Monica T Pupo , Jon Clardy

Bacterial diketopiperazines stimulate diatom growth and lipid accumulation.

Plant physiology

Avec: John Sittmann , Munhyung Bae , Emily Mevers , Muzi Li , Andrew Quinn , Ganesh Sriram , Jon Clardy , Zhongchi Liu

Identification of a growth factor required for culturing specific fastidious oral bacteria.

Journal of oral microbiology

Avec: Pallavi Murugkar , Eric Dimise , Eric Stewart , Stéphane N Viala , Jon Clardy , Floyd E Dewhirst , Kim Lewis

Pollen

Frontiers in microbiology

Avec: Kirk J Grubbs , Daniel S May , Joseph A Sardina , Renee K Dermenjian , Thomas P Wyche , Adrián A Pinto-Tomás , Jon Clardy , Cameron R Currie

Plasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in

ACS chemical biology

Avec: David R Jackson , Chelsi D Cassilly , Damian R Plichta , Hera Vlamakis , Hualan Liu , Stephen B Melville , Ramnik J Xavier , Jon Clardy

Microbial community modulates growth of symbiotic fungus required for stingless bee metamorphosis.

PloS one

Avec: Camila Raquel Paludo , Gleb Pishchany , Andres Andrade-Dominguez , Eduardo Afonso Silva-Junior , Cristiano Menezes , Fabio Santos Nascimento , Cameron R Currie , Roberto Kolter , Jon Clardy , Mônica Tallarico Pupo

Pyonitrins A-D: Chimeric Natural Products Produced by

Journal of the American Chemical Society

Avec: Emily Mevers , Josep Saurí , Eric J N Helfrich , Matthew Henke , Kenneth J Barns , Tim S Bugni , David Andes , Cameron R Currie , Jon Clardy

Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A.

Science (New York, N.Y.)

Avec: Solomon H Reisberg , Yang Gao , Allison S Walker , Eric J N Helfrich , Jon Clardy , Phil S Baran

Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering.

Beilstein journal of organic chemistry

Avec: Eric J N Helfrich , Geng-Min Lin , Christopher A Voigt , Jon Clardy

Applied and environmental microbiology

Avec: Charlotte B Francoeur , Daniel S May , Margaret W Thairu , Don Q Hoang , Olivia Panthofer , Tim S Bugni , Mônica T Pupo , Jon Clardy , Adrián A Pinto-Tomás , Cameron R Currie

Neuronal control of maternal provisioning in response to social cues.

Science advances

Avec: Jadiel A Wasson , Gareth Harris , Sabine Keppler-Ross , Trisha J Brock , Abdul R Dar , Rebecca A Butcher , Sylvia E J Fischer , Konstantinos Kagias , Jon Clardy , Yun Zhang , Susan E Mango

Revisiting Coley's Toxins: Immunogenic Cardiolipins from

Journal of the American Chemical Society

Avec: Yern-Hyerk Shin , Sunghee Bang , Sung-Moo Park , Xiao Ma , Chelsi Cassilly , Daniel Graham , Ramnik Xavier , Jon Clardy

Benefiting from big data in natural products: importance of preserving foundational skills and prioritizing data quality.

Natural product reports

Avec: Nadja B Cech , Marnix H Medema , Jon Clardy

A Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters.

Journal of chemical information and modeling

Avec: Allison S Walker , Jon Clardy

Lyme Disease,

Journal of the American Chemical Society

Avec: Dávid Szamosvári , Munhyung Bae , Sunghee Bang , Betsabeh Khoramian Tusi , Chelsi D Cassilly , Sung-Moo Park , Daniel B Graham , Ramnik J Xavier , Jon Clardy

A Cardiolipin from

Journal of the American Chemical Society

Avec: Sunghee Bang , Yern-Hyerk Shin , Xiao Ma , Sung-Moo Park , Daniel B Graham , Ramnik J Xavier , Jon Clardy

Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra.

Nature microbiology

Avec: Andrew M King , Zhengan Zhang , Emerson Glassey , Piro Siuti , Jon Clardy , Christopher A Voigt

Functional Redundancy and Dual Function of a Hypothetical Protein in the Biosynthesis of Eunicellane-Type Diterpenoids.

ACS chemical biology

Avec: Ayesha Ahmed Chaudhri , Yuya Kakumu , Sirinthra Thiengmag , Jack Chun-Ting Liu , Geng-Min Lin , Suhan Durusu , Friederike Biermann , Miriam Boeck , Christopher A Voigt , Jon Clardy , Reiko Ueoka , Allison S Walker , Eric J N Helfrich

Réseau de co-auteurs

Cameron R Currie 8 collaborations

Ramnik J Xavier 8 collaborations

Chelsi D Cassilly 7 collaborations

Munhyung Bae 6 collaborations

Eric J N Helfrich 6 collaborations

Emily Mevers 5 collaborations

Sung-Moo Park 4 collaborations

Hera Vlamakis 4 collaborations

Sunghee Bang 4 collaborations

Gleb Pishchany 3 collaborations

Timothy R Ramadhar 3 collaborations

Tim S Bugni 3 collaborations

Daniel B Graham 3 collaborations

Allison S Walker 3 collaborations

Christopher A Voigt 3 collaborations

Eric Dimise 2 collaborations

Ki Hyun Kim 2 collaborations

Kim Lewis 2 collaborations

Jaeyoung Kwon 2 collaborations

Dávid Szamosvári 2 collaborations

Andrew S Bolze 2 collaborations

David R Jackson 2 collaborations

Roberta M O'Connor 2 collaborations

Felix J Nepveux V 2 collaborations

Rachel M Bone Relat 2 collaborations

Kirk J Grubbs 2 collaborations

David R Andes 2 collaborations

Monica T Pupo 2 collaborations

Betsabeh Khoramian Tusi 2 collaborations

Eric M Brown 2 collaborations

Matthew T Henke 2 collaborations

Daniel S May 2 collaborations

Adrián A Pinto-Tomás 2 collaborations

Geng-Min Lin 2 collaborations

Yern-Hyerk Shin 2 collaborations

Xiao Ma 2 collaborations

Lin Su 1 collaboration

Moshe Baruch 1 collaboration

Jose Cornejo 1 collaboration

Elissa Hobert 1 collaboration

Caroline M Ajo-Franklin 1 collaboration

Philip Strandwitz 1 collaboration

Darya Terekhova 1 collaboration

Joanne K Liu 1 collaboration

Anukriti Sharma 1 collaboration

Jennifer Levering 1 collaboration

Daniel McDonald 1 collaboration

David Dietrich 1 collaboration

Asama Lekbua 1 collaboration

Nader Mroue 1 collaboration

Conor Liston 1 collaboration

Eric J Stewart 1 collaboration

Marc J Dubin 1 collaboration

Karsten Zengler 1 collaboration

Rob Knight 1 collaboration

Jack A Gilbert 1 collaboration

Lihua Ye 1 collaboration

Sairam V Jabba 1 collaboration

Daniel W Thorpe 1 collaboration

Alyce M Martin 1 collaboration

Hsiu-Yi Lu 1 collaboration

Jinhu Wang 1 collaboration

John D Thompson 1 collaboration

Colin R Lickwar 1 collaboration

Kenneth D Poss 1 collaboration

Damien J Keating 1 collaboration

Sven-Eric Jordt 1 collaboration

Rodger A Liddle 1 collaboration

John F Rawls 1 collaboration

Jia-Xuan Yan 1 collaboration

Qihao Wu 1 collaboration

Marc G Chevrette 1 collaboration

Doug R Braun 1 collaboration

Heino Heyman 1 collaboration

Gene E Ananiev 1 collaboration

Scott R Rajski 1 collaboration

Mohammad R Seyedsayamdost 1 collaboration

Ziyang Zheng 1 collaboration

Hung-Wen Liu 1 collaboration

Jaypee Abenoja 1 collaboration

Gregory Bowden 1 collaboration

Patricia Reis 1 collaboration

Josiah Beaushaw 1 collaboration

Iwona Driskell 1 collaboration

Fernanda Gimenez 1 collaboration

Michael W Riggs 1 collaboration

Deborah A Schaefer 1 collaboration

Eric W Schmidt 1 collaboration

Zhenjian Lin 1 collaboration

Daniel L Distel 1 collaboration

David R Allred 1 collaboration

Heather M Fritz 1 collaboration

Pradipsinh Rathod 1 collaboration

Laura Chery 1 collaboration

John White 1 collaboration

Louise A Rollins-Smith 1 collaboration

Antonio C Ruzzini 1 collaboration

J Scott Fites 1 collaboration

Laura K Reinert 1 collaboration

Emily M Hall 1 collaboration

Bryan A Joosse 1 collaboration

Vishvaas I Ravikumar 1 collaboration

Megan I Huebner 1 collaboration

Audrey Aka 1 collaboration

Miles H Kehs 1 collaboration

Bria M Gillard 1 collaboration

Emily Doe 1 collaboration

Julia A Tasca 1 collaboration

Thomas P Umile 1 collaboration

Kevin P C Minbiole 1 collaboration

Frank Surup 1 collaboration

Peter H W Biedermann 1 collaboration

Bradon R McDonald 1 collaboration

Jonathan L Klassen 1 collaboration

Caitlin M Carlson 1 collaboration

Taise T H Fukuda 1 collaboration

Weilan G P Melo 1 collaboration

Ethan B Van Arnam 1 collaboration

Xiaoxi Liu 1 collaboration

Xiangjun Chen 1 collaboration

Pavel Filipčík 1 collaboration

Zehua Liu 1 collaboration

Sara J Buhrlage 1 collaboration

Virginia J Glick 1 collaboration

Cecilia A Webber 1 collaboration

Lauren E Simmons 1 collaboration

Morgan C Martin 1 collaboration

Maryam Ahmad 1 collaboration

Cecilia H Kim 1 collaboration

Amanda N D Adams 1 collaboration

Michael C Chao 1 collaboration

Nicole C Howard 1 collaboration

Sarah M Fortune 1 collaboration

Manasvi Verma 1 collaboration

Marco Jost 1 collaboration

Lalit K Beura 1 collaboration

Michael J James 1 collaboration

Seo Yoon Lee 1 collaboration

Caroline M Mitchell 1 collaboration

Smita Gopinath 1 collaboration

Gregory D Bowden 1 collaboration

Patricia M Reis 1 collaboration

Maxwell B Rogers 1 collaboration

Kelly A Brayton 1 collaboration

Sarah K Wilson 1 collaboration

Bruno Martorelli Di Genova 1 collaboration

Laura J Knoll 1 collaboration

Albert K Tai 1 collaboration

Douglas J Kenny 1 collaboration

Sarah G Whaley 1 collaboration

Charles O Rock 1 collaboration

John Sittmann 1 collaboration

Muzi Li 1 collaboration

Andrew Quinn 1 collaboration

Ganesh Sriram 1 collaboration

Zhongchi Liu 1 collaboration

Pallavi Murugkar 1 collaboration

Eric Stewart 1 collaboration

Stéphane N Viala 1 collaboration

Floyd E Dewhirst 1 collaboration

Joseph A Sardina 1 collaboration

Renee K Dermenjian 1 collaboration

Thomas P Wyche 1 collaboration

Damian R Plichta 1 collaboration

Hualan Liu 1 collaboration

Stephen B Melville 1 collaboration

Camila Raquel Paludo 1 collaboration

Andres Andrade-Dominguez 1 collaboration

Eduardo Afonso Silva-Junior 1 collaboration

Cristiano Menezes 1 collaboration

Fabio Santos Nascimento 1 collaboration

Roberto Kolter 1 collaboration

Mônica Tallarico Pupo 1 collaboration

Josep Saurí 1 collaboration

Matthew Henke 1 collaboration

Kenneth J Barns 1 collaboration

David Andes 1 collaboration

Solomon H Reisberg 1 collaboration

Yang Gao 1 collaboration

Phil S Baran 1 collaboration

Charlotte B Francoeur 1 collaboration

Margaret W Thairu 1 collaboration

Don Q Hoang 1 collaboration

Olivia Panthofer 1 collaboration

Mônica T Pupo 1 collaboration

Jadiel A Wasson 1 collaboration

Gareth Harris 1 collaboration

Sabine Keppler-Ross 1 collaboration

Trisha J Brock 1 collaboration

Abdul R Dar 1 collaboration

Rebecca A Butcher 1 collaboration

Sylvia E J Fischer 1 collaboration

Konstantinos Kagias 1 collaboration

Yun Zhang 1 collaboration

Susan E Mango 1 collaboration

Chelsi Cassilly 1 collaboration

Daniel Graham 1 collaboration

Ramnik Xavier 1 collaboration

Nadja B Cech 1 collaboration

Marnix H Medema 1 collaboration

Andrew M King 1 collaboration

Zhengan Zhang 1 collaboration

Emerson Glassey 1 collaboration

Piro Siuti 1 collaboration

Ayesha Ahmed Chaudhri 1 collaboration

Yuya Kakumu 1 collaboration

Sirinthra Thiengmag 1 collaboration

Jack Chun-Ting Liu 1 collaboration

Suhan Durusu 1 collaboration

Friederike Biermann 1 collaboration

Miriam Boeck 1 collaboration

Reiko Ueoka 1 collaboration