Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.

Animals Animals, Genetically Modified Cholinergic Neurons / metabolism Edwardsiella tarda / metabolism Enteric Nervous System / cytology Enteroendocrine Cells / physiology Gastrointestinal Motility / physiology Intestinal Mucosa / cytology Proto-Oncogene Proteins c-ret / genetics Serotonin / metabolism Signal Transduction TRPA1 Cation Channel / metabolism Tryptophan / metabolism Zebrafish Zebrafish Proteins / genetics
Danio rerio bacterial tryptophan catabolism enteroendocrine cells gut microbes gut-brain axis communication indole indole-3-carboxaldehyde intestinal peristalsis serotonin

Journal

Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316

Informations de publication

Date de publication:
10 02 2021
Historique:
received: 23 06 2020
revised: 08 09 2020
accepted: 19 11 2020
pubmed: 23 12 2020
medline: 17 8 2021
entrez: 22 12 2020
Statut: ppublish

Résumé

The intestinal epithelium senses nutritional and microbial stimuli using epithelial sensory enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous system, but whether they also relay signals from intestinal microbes remains unknown. Using in vivo real-time measurements of EEC and nervous system activity in zebrafish, we discovered that the bacteria Edwardsiella tarda activate EECs through the receptor transient receptor potential ankyrin A1 (Trpa1) and increase intestinal motility. Microbial, pharmacological, or optogenetic activation of Trpa1

Identifiants

DOI: 10.1016/j.chom.2020.11.011 PMID: 33352109 PMC: PMC7997396
pubmed: 33352109
pii: S1931-3128(20)30633-8
doi: 10.1016/j.chom.2020.11.011
pmc: PMC7997396
mid: NIHMS1658039
pii:
doi:

Substances chimiques

TRPA1 Cation Channel 0
Zebrafish Proteins 0
Serotonin 333DO1RDJY
Tryptophan 8DUH1N11BX
Proto-Oncogene Proteins c-ret EC 2.7.10.1
Ret protein, zebrafish EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

179-196.e9

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM074057
Pays : United States
Organisme : NCCIH NIH HHS
ID : F32 AT010415
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL150713
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK093399
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK125527
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007568
Pays : United States
Organisme : NIH HHS
ID : S10 OD020010
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109368
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES030672
Pays : United States
Organisme : BLRD VA
ID : I01 BX002230
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Lihua Ye (L)

Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA; Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

Munhyung Bae (M)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Chelsi D Cassilly (CD)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Sairam V Jabba (SV)

Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA.

Daniel W Thorpe (DW)

Flinders Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.

Alyce M Martin (AM)

Flinders Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.

Hsiu-Yi Lu (HY)

Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA.

Jinhu Wang (J)

Division of Cardiology, School of Medicine, Emory University, Atlanta, GA 30322, USA.

John D Thompson (JD)

Department of Cell Biology, Regeneration Next, Duke University School of Medicine, Durham, NC 27710, USA.

Colin R Lickwar (CR)

Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA; Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

Kenneth D Poss (KD)

Department of Cell Biology, Regeneration Next, Duke University School of Medicine, Durham, NC 27710, USA.

Damien J Keating (DJ)

Flinders Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.

Sven-Eric Jordt (SE)

Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA.

Jon Clardy (J)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Rodger A Liddle (RA)

Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Department of Veterans Affairs, Durham, NC 27705, USA.

John F Rawls (JF)

Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA; Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: john.rawls@duke.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Cellules › Neurones › Neurones cholinergiques › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Edwardsiella › Edwardsiella tarda › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Système nerveux autonome › Système nerveux entérique › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Motilité gastrointestinale › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-ret › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Membre-1 de la sous-famille A de canaux cationiques à potentiel de récepteur transitoire › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Tryptophane › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Enteroendocrine cells sense bacterial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de poisson › Protéines de poisson-zèbre › Enteroendocrine cells sense bacterial...