Lyme Disease,
Animals
Antigens, Bacterial
/ chemistry
Bone Marrow Cells
/ drug effects
Borrelia burgdorferi
/ chemistry
Dendritic Cells
/ drug effects
Galactolipids
/ chemical synthesis
Inflammation
/ chemically induced
Lyme Disease
/ immunology
Mice
Toll-Like Receptor 2
/ metabolism
Tumor Necrosis Factor-alpha
/ metabolism
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
16 02 2022
16 02 2022
Historique:
pubmed:
8
2
2022
medline:
12
3
2022
entrez:
7
2
2022
Statut:
ppublish
Résumé
The human immune system detects potentially pathogenic microbes with receptors that respond to microbial metabolites. While the overall immune signaling pathway is known in considerable detail, the initial molecular signals, the microbially produced immunogens, for important diseases like Lyme disease (LD) are often not well-defined. The immunogens for LD are produced by the spirochete
Identifiants
pubmed: 35129341
doi: 10.1021/jacs.1c12202
doi:
Substances chimiques
Antigens, Bacterial
0
Galactolipids
0
Tlr2 protein, mouse
0
Toll-Like Receptor 2
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2474-2478Subventions
Organisme : NCCIH NIH HHS
ID : R01 AT009708
Pays : United States