Akkermansia muciniphila phospholipid induces homeostatic immune responses.

Akkermansia / chemistry Cell Membrane / chemistry Cytokines / immunology Homeostasis / immunology Humans Immunity Inflammation Mediators / chemical synthesis Phosphatidylethanolamines / chemical synthesis Structure-Activity Relationship Toll-Like Receptor 1 / immunology Toll-Like Receptor 2 / agonists

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
08 2022
Historique:
received: 21 01 2021
accepted: 16 06 2022
pubmed: 28 7 2022
medline: 9 8 2022
entrez: 27 7 2022
Statut: ppublish

Résumé

Multiple studies have established associations between human gut bacteria and host physiology, but determining the molecular mechanisms underlying these associations has been challenging

Identifiants

DOI: 10.1038/s41586-022-04985-7 PMID: 35896748 PMC: PMC9328018
pubmed: 35896748
doi: 10.1038/s41586-022-04985-7
pii: 10.1038/s41586-022-04985-7
pmc: PMC9328018
doi:

Substances chimiques

Cytokines 0
Inflammation Mediators 0
Phosphatidylethanolamines 0
TLR1 protein, human 0
TLR2 protein, human 0
Toll-Like Receptor 1 0
Toll-Like Receptor 2 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

168-173

Subventions

Organisme : NCCIH NIH HHS
ID : R01 AT009708
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK043351
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK127171
Pays : United States
Organisme : NIDDK NIH HHS
ID : RC2 DK114784
Pays : United States
Organisme : NCCIH NIH HHS
ID : F32 AT010415
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK131742
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI172147
Pays : United States

Informations de copyright

© 2022. The Author(s).

Références

Nat Med. 2017 Jan;23(1):107-113
pubmed: 27892954
Immunobiology. 2008;213(3-4):205-24
pubmed: 18406368
Immunity. 2009 Dec 18;31(6):873-84
pubmed: 19931471
Science. 2019 Jun 21;364(6446):1179-1184
pubmed: 31221858
Elife. 2013 Sep 10;2:e01456
pubmed: 24040512
Mol Pharm. 2019 May 6;16(5):2037-2047
pubmed: 30924661
Nat Med. 2022 Feb;28(2):315-324
pubmed: 35115705
Methods Mol Biol. 2019;1979:25-44
pubmed: 31028630
Front Microbiol. 2017 Sep 22;8:1765
pubmed: 29018410
Nat Med. 2019 Jul;25(7):1096-1103
pubmed: 31263284
Cell. 2007 Sep 21;130(6):1071-82
pubmed: 17889651
Chemistry. 2006 May 15;12(15):4170-5
pubmed: 16541473
Nutrients. 2020 Sep 20;12(9):
pubmed: 32962219
Science. 2021 Aug 27;373(6558):966-967
pubmed: 34446595
Nat Rev Immunol. 2014 Sep;14(9):585-600
pubmed: 25145755
Nat Rev Microbiol. 2008 Mar;6(3):222-33
pubmed: 18264115
Nat Rev Clin Oncol. 2018 Jun;15(6):382-396
pubmed: 29636538
Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12672-12677
pubmed: 31182571
Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26157-26166
pubmed: 31811024
Sci Adv. 2015;1(3):
pubmed: 26101787
PLoS One. 2017 Mar 1;12(3):e0173004
pubmed: 28249045
Nat Biotechnol. 2016 May;34(5):525-7
pubmed: 27043002
Curr Opin Immunol. 2008 Aug;20(4):414-9
pubmed: 18585456
Nature. 2021 Dec;600(7888):302-307
pubmed: 34759313
Curr Protoc Immunol. 2015 Apr 01;109:14.12.1-14.12.10
pubmed: 25845562
BMJ. 2018 Jun 13;361:k2139
pubmed: 29898882
Microorganisms. 2018 Jul 23;6(3):
pubmed: 30041463
J Med Chem. 2019 Mar 28;62(6):2938-2949
pubmed: 30829478
Cell. 2018 Mar 8;172(6):1198-1215
pubmed: 29522742
FEMS Microbiol Rev. 2016 Jan;40(1):133-59
pubmed: 25862689
Synth Commun. 2012 Dec 1;42(24):3614-3618
pubmed: 23264701
Bioinformatics. 2016 Oct 1;32(19):3047-8
pubmed: 27312411
Nat Rev Microbiol. 2021 Jan;19(1):55-71
pubmed: 32887946
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8698-E8706
pubmed: 30150374
Org Biomol Chem. 2020 Jul 15;18(27):5073-5094
pubmed: 32582902
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Nov;1862(11):1300-1309
pubmed: 27668701
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
Acta Crystallogr D Struct Biol. 2017 Feb 1;73(Pt 2):112-122
pubmed: 28177307
Nat Rev Immunol. 2004 Jul;4(7):499-511
pubmed: 15229469
F1000Res. 2018 Aug 24;7:1338
pubmed: 30254741
Nat Chem Biol. 2018 Nov;14(11):1021-1031
pubmed: 30327559
Science. 2018 Jan 5;359(6371):91-97
pubmed: 29097494
Immunity. 2017 Apr 18;46(4):562-576
pubmed: 28423337
Front Immunol. 2020 Apr 09;11:645
pubmed: 32328074
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71
pubmed: 23671105
Protein Sci. 2018 Jan;27(1):14-25
pubmed: 28710774
J Phys Chem B. 2019 Jul 11;123(27):5814-5821
pubmed: 31251616

Auteurs

Munhyung Bae (M)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.
College of Pharmacy, Gachon University, Incheon, South Korea.

Chelsi D Cassilly (CD)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.
ORCID: 0000-0001-9611-7438

Xiaoxi Liu (X)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.
Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

Sung-Moo Park (SM)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Betsabeh Khoramian Tusi (BK)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Xiangjun Chen (X)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Jaeyoung Kwon (J)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.
Natural Product Informatics Research Center, Korea Institute of Science and Technology (KIST), Ganeung, South Korea.

Pavel Filipčík (P)

Biochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
SBGrid Consortium, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.

Andrew S Bolze (AS)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Zehua Liu (Z)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Hera Vlamakis (H)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0003-1086-9191

Daniel B Graham (DB)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-8403-8115

Sara J Buhrlage (SJ)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.
Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

Ramnik J Xavier (RJ)

Broad Institute of MIT and Harvard, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.
Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.
ORCID: 0000-0002-5630-5167

Jon Clardy (J)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA. jon_clardy@hms.harvard.edu.
ORCID: 0000-0003-0213-8356

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Verrucomicrobia › Akkermansia (genre) › Akkermansia muciniphila phospholipid induces...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Akkermansia muciniphila phospholipid induces...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Akkermansia muciniphila phospholipid induces...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Akkermansia muciniphila phospholipid induces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Akkermansia muciniphila phospholipid induces...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Akkermansia muciniphila phospholipid induces...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Akkermansia muciniphila phospholipid induces...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyléthanolamine › Akkermansia muciniphila phospholipid induces...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Akkermansia muciniphila phospholipid induces...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-1 › Akkermansia muciniphila phospholipid induces...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-2 › Akkermansia muciniphila phospholipid induces...