Plasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in

Clostridium perfringens / genetics Enterococcus faecalis / metabolism Escherichia coli / genetics Genes, Bacterial Open Reading Frames Operon Oxidation-Reduction Plasmalogens / biosynthesis

Journal

ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906

Informations de publication

Date de publication:
15 01 2021
Historique:
pubmed: 23 12 2020
medline: 8 7 2021
entrez: 22 12 2020
Statut: ppublish

Résumé

Plasmalogens are vinyl ether-containing lipids produced by mammals and bacteria. The aerobic biosynthetic pathway in eukaryotes and bacteria is known, but the anaerobic pathway has remained a mystery. Here, we describe a two-gene operon (plasmalogen synthase,

Identifiants

DOI: 10.1021/acschembio.0c00673 PMID: 33350306 PMC: PMC7812594
pubmed: 33350306
doi: 10.1021/acschembio.0c00673
pmc: PMC7812594
doi:

Substances chimiques

Plasmalogens 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

6-13

Subventions

Organisme : NCCIH NIH HHS
ID : F32 AT010415
Pays : United States
Organisme : NIGMS NIH HHS
ID : F32 GM122233
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT009708
Pays : United States

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Auteurs

David R Jackson (DR)

Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston Massachusetts 02115, United States.
ORCID: 0000-0002-8676-9464

Chelsi D Cassilly (CD)

Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston Massachusetts 02115, United States.

Damian R Plichta (DR)

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.

Hera Vlamakis (H)

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.

Hualan Liu (H)

Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia 24061, United States.

Stephen B Melville (SB)

Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia 24061, United States.

Ramnik J Xavier (RJ)

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.
Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.

Jon Clardy (J)

Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston Massachusetts 02115, United States.
ORCID: 0000-0003-0213-8356

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bactéries à Gram positif formant des endospores › Clostridium › Clostridium perfringens › Plasmalogen Biosynthesis by Anaerobic...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Lactobacillales › Enterococcaceae › Enterococcus › Enterococcus faecalis › Plasmalogen Biosynthesis by Anaerobic...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Plasmalogen Biosynthesis by Anaerobic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Gènes bactériens › Plasmalogen Biosynthesis by Anaerobic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Cadres ouverts de lecture › Plasmalogen Biosynthesis by Anaerobic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Opéron › Plasmalogen Biosynthesis by Anaerobic...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Plasmalogen Biosynthesis by Anaerobic...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Éther-phospholipides › Acétalphosphatides › Plasmalogen Biosynthesis by Anaerobic...