Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside.
Molecular pathomechanisms of radiation-induced heart disease
Onco-cardiology
Prevention and therapy of radiation-induced heart disease
Radiation heart sequelae
Journal
Clinical research in cardiology : official journal of the German Cardiac Society
ISSN: 1861-0692
Titre abrégé: Clin Res Cardiol
Pays: Germany
ID NLM: 101264123
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
29
10
2020
accepted:
16
01
2021
pubmed:
17
2
2021
medline:
20
11
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
Cancer management has undergone significant improvements, which led to increased long-term survival rates among cancer patients. Radiotherapy (RT) has an important role in the treatment of thoracic tumors, including breast, lung, and esophageal cancer, or Hodgkin's lymphoma. RT aims to kill tumor cells; however, it may have deleterious side effects on the surrounding normal tissues. The syndrome of unwanted cardiovascular adverse effects of thoracic RT is termed radiation-induced heart disease (RIHD), and the risk of developing RIHD is a critical concern in current oncology practice. Premature ischemic heart disease, cardiomyopathy, heart failure, valve abnormalities, and electrical conduct defects are common forms of RIHD. The underlying mechanisms of RIHD are still not entirely clear, and specific therapeutic interventions are missing. In this review, we focus on the molecular pathomechanisms of acute and chronic RIHD and propose preventive measures and possible pharmacological strategies to minimize the burden of RIHD.
Identifiants
pubmed: 33591377
doi: 10.1007/s00392-021-01809-y
pii: 10.1007/s00392-021-01809-y
pmc: PMC8055626
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
507-531Subventions
Organisme : Hungarian Scientific Research Fund
ID : FK129094
Organisme : Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
ID : GINOP-2.3.2-15-2016-00040
Organisme : Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
ID : EFOP-3.6.2-16-2017-00006 (LIVE LONGER)
Organisme : Emberi Eroforrások Minisztériuma
ID : ÚNKP-20-5-SZTE-166
Organisme : Emberi Eroforrások Minisztériuma
ID : ÚNKP-20-4-SZTE-150
Organisme : Emberi Eroforrások Minisztériuma
ID : UNKP-19-3-SZTE-159
Organisme : Emberi Eroforrások Minisztériuma
ID : UNKP-19-3-SZTE-160
Organisme : Magyar Tudományos Akadémia
ID : Bolyai János Kutatási Ösztöndíj
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