Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption.
PDAC
ROS
cancer
centrosome amplification
exosomes
extracellular vesicles
invasion
lysosomes
multivesicular bodies
stellate cells
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
12 04 2021
12 04 2021
Historique:
received:
20
08
2020
revised:
01
12
2020
accepted:
08
01
2021
pubmed:
17
2
2021
medline:
22
1
2022
entrez:
16
2
2021
Statut:
ppublish
Résumé
Bidirectional communication between cells and their surrounding environment is critical in both normal and pathological settings. Extracellular vesicles (EVs), which facilitate the horizontal transfer of molecules between cells, are recognized as an important constituent of cell-cell communication. In cancer, alterations in EV secretion contribute to the growth and metastasis of tumor cells. However, the mechanisms underlying these changes remain largely unknown. Here, we show that centrosome amplification is associated with and sufficient to promote small extracellular vesicle (
Identifiants
pubmed: 33592190
pii: S0960-9822(21)00061-0
doi: 10.1016/j.cub.2021.01.028
pmc: PMC8047808
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1403-1416.e7Subventions
Organisme : Cancer Research UK
ID : C355/A25137
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C10847/A27781
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T000538/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P009417/1
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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