Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy.
Adjuvants, Immunologic
/ therapeutic use
Animals
Antiviral Agents
/ immunology
COVID-19
/ immunology
COVID-19 Vaccines
/ immunology
Granulocyte-Macrophage Colony-Stimulating Factor
/ immunology
Humans
MAP Kinase Signaling System
/ drug effects
Macrophages, Alveolar
/ immunology
Recombinant Proteins
/ immunology
SARS-CoV-2
/ immunology
IFN
Pro-inflammatory cytokines
Vaccine
Virus
Journal
Cytokine & growth factor reviews
ISSN: 1879-0305
Titre abrégé: Cytokine Growth Factor Rev
Pays: England
ID NLM: 9612306
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
09
10
2020
revised:
28
12
2020
accepted:
04
01
2021
pubmed:
18
2
2021
medline:
25
5
2021
entrez:
17
2
2021
Statut:
ppublish
Résumé
GM-CSF acts as a pro-inflammatory cytokine and a key growth factor produced by several immune cells such as macrophages and activated T cells. In this review, we discuss recent studies that point to the crucial role of GM-CSF in the immune response against infections. Upon induction, GM-CSF activates four main signalling networks including the JAK/STAT, PI3K, MAPK, and NFκB pathways. Many of these transduction pathways such as JAK/STAT signal via proteins commonly activated with other antiviral signalling cascades, such as those induced by IFNs. GM-CSF also helps defend against respiratory infections by regulating alveolar macrophage differentiation and enhancing innate immunity in the lungs. Here, we also summarize the numerous clinical trials that have taken advantage of GM-CSF's mechanistic attributes in immunotherapy. Moreover, we discuss how GM-CSF is used as an adjuvant in vaccines and how its activity is interfered with to reduce inflammation such as in the case of COVID-19. This review brings forth the current knowledge on the antiviral actions of GM-CSF, the associated signalling cascades, and its application in immunotherapy.
Identifiants
pubmed: 33593661
pii: S1359-6101(21)00001-0
doi: 10.1016/j.cytogfr.2021.01.001
pmc: PMC8064670
pii:
doi:
Substances chimiques
Adjuvants, Immunologic
0
Antiviral Agents
0
COVID-19 Vaccines
0
Recombinant Proteins
0
sargramostim
5TAA004E22
Granulocyte-Macrophage Colony-Stimulating Factor
83869-56-1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-110Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
J Immunol. 2019 May 15;202(10):3033-3040
pubmed: 30988114
Am J Respir Crit Care Med. 2009 Sep 15;180(6):521-32
pubmed: 19590023
Cell Signal. 1998 Oct;10(9):619-28
pubmed: 9794243
J Virol. 1998 Jun;72(6):4962-9
pubmed: 9573265
Ann Rheum Dis. 2017 Jun;76(6):1020-1030
pubmed: 28213566
Am J Respir Crit Care Med. 2011 Jul 15;184(2):259-68
pubmed: 21474645
JAMA. 1998 Mar 11;279(10):756-61
pubmed: 9508151
PLoS Pathog. 2014 Jul 17;10(7):e1004146
pubmed: 25033082
Br J Cancer. 2019 Jan;120(1):6-15
pubmed: 30413827
Crit Care Med. 2013 Jan;41(1):224-36
pubmed: 23222256
Front Immunol. 2019 Sep 04;10:2055
pubmed: 31552022
Eur J Immunol. 2007 Sep;37(9):2518-28
pubmed: 17694571
Virology. 2010 Oct 10;406(1):80-7
pubmed: 20667572
Cell Death Dis. 2018 Feb 15;9(3):267
pubmed: 29449600
J Cell Physiol. 1980 Jun;103(3):435-45
pubmed: 6967488
PLoS One. 2015 Apr 29;10(4):e0124593
pubmed: 25923215
Viral Immunol. 1989 Fall;2(3):163-73
pubmed: 2483503
J Virol. 2001 Dec;75(24):12128-40
pubmed: 11711604
Science. 1994 Apr 29;264(5159):713-6
pubmed: 8171324
Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1135-44
pubmed: 23640482
AIDS Res Hum Retroviruses. 1998 Jan 20;14(2):129-38
pubmed: 9462923
Cold Spring Harb Perspect Med. 2012 Aug 01;2(8):
pubmed: 22908191
J Immunol. 2010 Aug 1;185(3):1606-15
pubmed: 20622119
Nat Immunol. 2011 Mar;12(3):231-8
pubmed: 21240265
J Leukoc Biol. 2016 Jun;99(6):1089-106
pubmed: 26667473
Genes Dev. 2003 Feb 15;17(4):455-60
pubmed: 12600939
J Infect Dis. 2014 Jun 1;209(11):1827-36
pubmed: 24367039
J Clin Virol. 2003 Apr;26(3):339-46
pubmed: 12637083
BMC Infect Dis. 2017 Mar 24;17(1):228
pubmed: 28340570
Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7
pubmed: 2430286
J Virol. 2009 Jun;83(11):5683-92
pubmed: 19297466
Blood. 1996 Jul 1;88(1):202-10
pubmed: 8704175
Cell Rep. 2019 Oct 22;29(4):860-872.e5
pubmed: 31644909
J Virol. 2000 Feb;74(3):1313-20
pubmed: 10627542
Cold Spring Harb Perspect Biol. 2014 Sep 04;6(10):a016295
pubmed: 25190079
AIDS. 2000 Mar 10;14(4):387-95
pubmed: 10770541
PLoS One. 2011;6(9):e24559
pubmed: 21931755
J Clin Pathol. 1994 Sep;47(9):855-7
pubmed: 7962659
Blood. 1980 Dec;56(6):947-58
pubmed: 7002232
J Clin Invest. 2012 Oct;122(10):3652-64
pubmed: 22996662
J Immunol. 1997 Apr 15;158(8):3947-58
pubmed: 9103465
Curr Opin Virol. 2015 Jun;12:47-52
pubmed: 25771505
Nat Commun. 2016 Nov 07;7:13228
pubmed: 27819269
Cells. 2019 Aug 17;8(8):
pubmed: 31426476
Arthritis Res Ther. 2012 Sep 20;14(5):R199
pubmed: 22995428
Retrovirology. 2015 Feb 07;12:12
pubmed: 25809599
J Immunol. 2007 Apr 15;178(8):5245-52
pubmed: 17404308
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3402-7
pubmed: 17360658
Immunopharmacol Immunotoxicol. 1998 Aug;20(3):373-82
pubmed: 9736442
Mol Cell. 2018 Sep 6;71(5):825-840.e6
pubmed: 30100266
Clin Immunol. 2007 Dec;125(3):328-36
pubmed: 17827068
Immunity. 2016 Nov 15;45(5):963-973
pubmed: 27851925
Atherosclerosis. 2011 Feb;214(2):316-24
pubmed: 21159337
Immunol Rev. 2008 Dec;226:10-8
pubmed: 19161412
Am J Respir Cell Mol Biol. 2010 Jun;42(6):732-43
pubmed: 19617401
Clin Cancer Res. 2017 Sep 1;23(17):5034-5043
pubmed: 28536308
Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1560-5
pubmed: 19164548
Scand J Immunol. 2007 Apr;65(4):311-9
pubmed: 17386021
Front Immunol. 2017 Apr 21;8:459
pubmed: 28484457
Blood. 1992 Aug 15;80(4):995-1003
pubmed: 1379854
J Virol. 2003 Dec;77(23):12630-8
pubmed: 14610185
J Infect Dis. 2003 Dec 15;188(12):1804-14
pubmed: 14673758
Arch Virol. 2018 Jul;163(7):1889-1895
pubmed: 29594364
Blood. 1990 Mar 15;75(6):1215-9
pubmed: 2178702
J Infect Dis. 2000 Nov;182(5):1531-5
pubmed: 11023477
J Immunol. 2003 May 15;170(10):5195-202
pubmed: 12734367
J Clin Oncol. 2019 May 1;37(13):1051-1061
pubmed: 30817251
Biochem Biophys Res Commun. 2002 Jun 7;294(2):414-22
pubmed: 12051728
PLoS One. 2009;4(1):e4176
pubmed: 19137067
AIDS. 2003 Aug 15;17(12):1731-40
pubmed: 12891059
Blood. 2012 Apr 12;119(15):3383-93
pubmed: 22323450
mBio. 2018 Mar 20;9(2):
pubmed: 29559569
J Virol. 2002 Feb;76(3):1071-6
pubmed: 11773383
Blood. 1996 Nov 1;88(9):3474-81
pubmed: 8896413
Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2367-72
pubmed: 10051648
Antiviral Res. 2011 Nov;92(2):319-28
pubmed: 21925209
Clin Exp Immunol. 1988 Apr;72(1):67-73
pubmed: 3260840
J Immunol. 2006 Apr 1;176(7):4343-51
pubmed: 16547272
Science. 2013 Feb 15;339(6121):786-91
pubmed: 23258413
J Clin Invest. 2001 Sep;108(6):887-94
pubmed: 11560958
Front Immunol. 2019 Jan 08;9:3086
pubmed: 30671058
Int J Mol Sci. 2019 Mar 21;20(6):
pubmed: 30901970
Viral Immunol. 2005;18(2):355-64
pubmed: 16035947
Drug Des Devel Ther. 2017 Jan 13;11:211-223
pubmed: 28144129
Sci STKE. 2004 Nov 23;2004(260):tr8
pubmed: 15561980
AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1151-9
pubmed: 8844019
Immunity. 2019 Apr 16;50(4):796-811
pubmed: 30995500
J Exp Med. 1997 Nov 3;186(9):1591-6
pubmed: 9348317
J Allergy Clin Immunol. 2016 Mar;137(3):700-9.e9
pubmed: 26560044
J Immunol. 2002 Jan 15;168(2):562-8
pubmed: 11777947
J Leukoc Biol. 2005 Jun;77(6):914-22
pubmed: 15767289
Nat Rev Immunol. 2014 Jan;14(1):36-49
pubmed: 24362405
J Exp Med. 2013 Sep 23;210(10):1977-92
pubmed: 24043763
J Exp Med. 2020 Jan 6;217(1):
pubmed: 31611249
J Virol. 2008 May;82(9):4265-74
pubmed: 18287245
Front Microbiol. 2019 May 10;10:1057
pubmed: 31134045
Blood. 2002 Dec 1;100(12):4193-200
pubmed: 12393686
J Infect Dis. 2000 Jan;181(1):148-57
pubmed: 10608761
Am J Respir Crit Care Med. 2014 Mar 1;189(5):609-11
pubmed: 24579839
Cancer Res. 2004 Sep 1;64(17):6337-43
pubmed: 15342423
Natl Sci Rev. 2020 Jun;7(6):998-1002
pubmed: 34676125
Science. 1993 Sep 10;261(5127):1445-8
pubmed: 7690156
Blood. 2009 Aug 13;114(7):1289-98
pubmed: 19436055
Science. 1993 Mar 19;259(5102):1742-5
pubmed: 8456301
Nat Immunol. 2003 Jan;4(1):63-8
pubmed: 12469119
Annu Rev Immunol. 1998;16:293-322
pubmed: 9597132
Front Immunol. 2019 Nov 19;10:2674
pubmed: 31798594
Nat Rev Immunol. 2008 Jul;8(7):533-44
pubmed: 18551128
J Infect Dis. 1999 Oct;180(4):1064-71
pubmed: 10479132
Nat Rev Immunol. 2020 Aug;20(8):507-514
pubmed: 32576980
AIDS. 2000 Aug 18;14(12):1739-48
pubmed: 10985310
AIDS Res Hum Retroviruses. 1995 Sep;11(9):1031-8
pubmed: 8554900
Cytokine. 2020 Mar;127:154939
pubmed: 31786501
J Biomed Sci. 2009 Apr 20;16:41
pubmed: 19374779
J Gen Virol. 1994 Jan;75 ( Pt 1):101-10
pubmed: 8113718
J Neuroinflammation. 2012 Dec 13;9:268
pubmed: 23234315
Nat Immunol. 2003 Jan;4(1):69-77
pubmed: 12483210
J Biol Chem. 2008 May 23;283(21):14295-308
pubmed: 18332133
Lancet Rheumatol. 2020 Aug;2(8):e465-e473
pubmed: 32835256
J Virol. 2003 May;77(9):5493-8
pubmed: 12692250
Viral Immunol. 2020 Jul/Aug;33(6):477-488
pubmed: 32255741
Inflammation. 2018 Oct;41(5):1825-1834
pubmed: 29911275
Cell Mol Immunol. 2018 Feb;15(2):187-189
pubmed: 29057973
Mol Biol Cell. 2006 Jul;17(7):2896-909
pubmed: 16624862
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Nov;36(11):1037-45
pubmed: 22169717
Eur J Immunol. 2001 Sep;31(9):2566-73
pubmed: 11536154
J Biol Chem. 1994 May 13;269(19):14032-7
pubmed: 8188683
Biochem Pharmacol. 1990 Dec 15;40(12):2695-700
pubmed: 2260992
J Leukoc Biol. 2011 Jun;89(6):945-53
pubmed: 21393420
Blood. 2008 Jan 15;111(2):485-91
pubmed: 18182579
Blood. 1998 Jun 15;91(12):4752-60
pubmed: 9616174
J Immunol. 2001 Jun 15;166(12):7381-8
pubmed: 11390489