SARS-CoV-2 variants show resistance to neutralization by many monoclonal and serum-derived polyclonal antibodies.


Journal

Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035

Informations de publication

Date de publication:
10 Feb 2021
Historique:
entrez: 17 2 2021
pubmed: 18 2 2021
medline: 18 2 2021
Statut: epublish

Résumé

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global COVID-19 pandemic infecting more than 106 million people and causing 2.3 million deaths. The rapid deployment of antibody-based countermeasures has provided hope for curtailing disease and ending the pandemic

Identifiants

pubmed: 33594356
doi: 10.21203/rs.3.rs-228079/v1
pmc: PMC7885928
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAMS NIH HHS
ID : P30 AR073752
Pays : United States

Commentaires et corrections

Type : UpdateIn

Références

J Immunol. 2020 Aug 15;205(4):915-922
pubmed: 32591393
Nature. 2020 Jul;583(7815):290-295
pubmed: 32422645
Nat Med. 2021 Apr;27(4):622-625
pubmed: 33654292
Cell. 2020 Dec 10;183(6):1508-1519.e12
pubmed: 33207184
Science. 2021 Feb 19;371(6531):823-829
pubmed: 33495307
Nat Biotechnol. 2018 Nov;36(10):983-987
pubmed: 30247488
Nat Med. 2021 Apr;27(4):620-621
pubmed: 33558724
Cell Host Microbe. 2020 Sep 9;28(3):475-485.e5
pubmed: 32735849
Science. 2020 Nov 20;370(6519):950-957
pubmed: 32972994
Cell. 2020 Jun 25;181(7):1458-1463
pubmed: 32492407
Cell. 2020 Oct 1;183(1):169-184.e13
pubmed: 32931734
Cell. 2020 Nov 12;183(4):1024-1042.e21
pubmed: 32991844
Cell Rep Med. 2021 Apr 20;2(4):100230
pubmed: 33754147
Cell. 2021 Apr 29;184(9):2332-2347.e16
pubmed: 33761326
Elife. 2020 Oct 28;9:
pubmed: 33112236
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Nature. 2021 Apr;592(7852):116-121
pubmed: 33106671
Cell. 2021 Feb 18;184(4):861-880
pubmed: 33497610
Nat Med. 2020 Sep;26(9):1422-1427
pubmed: 32651581
Nat Protoc. 2021 Mar;16(3):1761-1784
pubmed: 33514944
Cell. 2021 Apr 1;184(7):1804-1820.e16
pubmed: 33691139
Cell. 2021 Apr 29;184(9):2316-2331.e15
pubmed: 33773105
Nature. 2021 Mar;591(7849):293-299
pubmed: 33494095
Bioinformatics. 2018 Sep 1;34(17):i884-i890
pubmed: 30423086
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):
pubmed: 34417349
Science. 2020 Aug 21;369(6506):1014-1018
pubmed: 32540904
Cell Host Microbe. 2021 Mar 10;29(3):477-488.e4
pubmed: 33535027
Nature. 2021 Apr;592(7855):616-622
pubmed: 33567448
Cell Host Microbe. 2020 May 13;27(5):841-848.e3
pubmed: 32289263
Cell Host Microbe. 2021 Jan 13;29(1):44-57.e9
pubmed: 33259788
Fly (Austin). 2012 Apr-Jun;6(2):80-92
pubmed: 22728672
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
Nature. 2020 Aug;584(7821):443-449
pubmed: 32668443
Nat Rev Immunol. 2020 Nov;20(11):709-713
pubmed: 33024281
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33211088
Euro Surveill. 2021 Jan;26(1):
pubmed: 33413740
Cell Rep. 2021 Jul 20;36(3):109400
pubmed: 34245672
Cell. 2021 Jan 7;184(1):15-17
pubmed: 33338422
J Gen Virol. 2020 Nov;101(11):1156-1169
pubmed: 32821033
Nat Med. 2021 Feb;27(2):205-211
pubmed: 33469205
Nature. 2021 Jul;595(7867):421-425
pubmed: 34030176
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Protein Sci. 2018 Jan;27(1):14-25
pubmed: 28710774

Auteurs

Michael Diamond (M)

Washington University School of Medicine.

Rita Chen (R)

Washington University School of Medicine.

Xuping Xie (X)

University of Texas Medical Branch.

James Case (J)

Washington University School of Medicine.

Laura VanBlargan (L)

Washington University.

Yang Liu (Y)

University of Texas Medical Branch.

Jianying Liu (J)

University of Texas Medical Branch.

John Errico (J)

Washington University.

Emma Winkler (E)

Washington University School of Medicine.

Naveenchandra Suryadevara (N)

Vanderbilt University Medical Center.

Stephen Tahan (S)

Washington University.

Jackson Turner (J)

Washington University School of Medicine.

Wooseob Kim (W)

Washington University School of Medicine.

Aaron Schmitz (A)

Washington University School of Medicine.

Mahima Thapa (M)

Washington University.

David Wang (D)

Washington University in St. Louis.

Andrianus Boon (A)

Washington University School of Medicine.

Dora Pinto (D)

Humabs BioMed SA, a subsidiary of Vir Biotechnology, Inc.

Rachel Presti (R)

Washington University School of Medicine.

Jane O'Halloran (J)

Washington University School of Medicine.

Alfred Kim (A)

Washington University.

Parakkal Deepak (P)

Washington University.

Daved Fremont (D)

Washington University School of Medicine.

Herbert Virgin (H)

Vir Biotechnology, Washington University School of Medicine.

James Crowe (J)

Vanderbilt University Medical Center.

Lindsay Droit (L)

Washington University School of Medicine.

Ali Ellebedy (A)

Washington University School of Medicine.

Pei-Yong Shi (PY)

The University of Texas Medical Branch at Galveston.

Pavlo Gilchuk (P)

Vanderbilt University Medical Center.

Classifications MeSH