Pavlo Gilchuk

Affiliations

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Publications (45)

Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.

Cell reports

Avec: Charles D Murin , Pavlo Gilchuk , Philipp A Ilinykh , Kai Huang , Natalia Kuzmina , Xiaoli Shen , Jessica F Bruhn , Aubrey L Bryan , Edgar Davidson , Benjamin J Doranz , Lauren E Williamson , Jeffrey Copps , Tanwee Alkutkar , Andrew I Flyak , Alexander Bukreyev , James E Crowe , Andrew B Ward

Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk.

Nature communications

Avec: Liam B King , Brandyn R West , Crystal L Moyer , Pavlo Gilchuk , Andrew Flyak , Philipp A Ilinykh , Robin Bombardi , Sean Hui , Kai Huang , Alexander Bukreyev , James E Crowe , Erica Ollmann Saphire

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell.

Cell reports

Avec: Maritza Puray-Chavez , Kyle M LaPak , Travis P Schrank , Jennifer L Elliott , Dhaval P Bhatt , Megan J Agajanian , Ria Jasuja , Dana Q Lawson , Keanu Davis , Paul W Rothlauf , Zhuoming Liu , Heejoon Jo , Nakyung Lee , Kasyap Tenneti , Jenna E Eschbach , Christian Shema Mugisha , Emily M Cousins , Erica W Cloer , Hung R Vuong , Laura A VanBlargan , Adam L Bailey , Pavlo Gilchuk , James E Crowe , Michael S Diamond , D Neil Hayes , Sean P J Whelan , Amjad Horani , Steven L Brody , Dennis Goldfarb , M Ben Major , Sebla B Kutluay

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals.

Cell reports

Avec: Elaine C Chen , Pavlo Gilchuk , Seth J Zost , Naveenchandra Suryadevara , Emma S Winkler , Carly R Cabel , Elad Binshtein , Rita E Chen , Rachel E Sutton , Jessica Rodriguez , Samuel Day , Luke Myers , Andrew Trivette , Jazmean K Williams , Edgar Davidson , Shuaizhi Li , Benjamin J Doranz , Samuel K Campos , Robert H Carnahan , Curtis A Thorne , Michael S Diamond , James E Crowe

Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region.

PLoS pathogens

Avec: Clara T Schoeder , Pavlo Gilchuk , Amandeep K Sangha , Kaitlyn V Ledwitch , Delphine C Malherbe , Xuan Zhang , Elad Binshtein , Lauren E Williamson , Cristina E Martina , Jinhui Dong , Erica Armstrong , Rachel Sutton , Rachel Nargi , Jessica Rodriguez , Natalia Kuzmina , Brooke Fiala , Neil P King , Alexander Bukreyev , James E Crowe , Jens Meiler

Antibodies targeting the glycan cap of Ebola virus glycoprotein are potent inducers of the complement.

Communications biology

Avec: Philipp A Ilinykh , Kai Huang , Bronwyn M Gunn , Natalia A Kuzmina , Kritika Kedarinath , Eduardo Jurado-Cobena , Fuchun Zhou , Chandru Subramani , Matthew A Hyde , Jalene V Velazquez , Lauren E Williamson , Pavlo Gilchuk , Robert H Carnahan , Galit Alter , James E Crowe , Alexander Bukreyev

Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics.

Nature biomedical engineering

Avec: Pavlo Gilchuk , Robin G Bombardi , Jesse H Erasmus , Qing Tan , Rachel Nargi , Cinque Soto , Peter Abbink , Todd J Suscovich , Lorellin A Durnell , Amit Khandhar , Jacob Archer , Jenny Liang , Mallorie E Fouch , Edgar Davidson , Benjamin J Doranz , Taylor Jones , Elise Larson , Stacey Ertel , Brian Granger , Jasmine Fuerte-Stone , Vicky Roy , Thomas Broge , Thomas C Linnekin , Caitlyn H Linde , Matthew J Gorman , Joseph Nkolola , Galit Alter , Steven G Reed , Dan H Barouch , Michael S Diamond , James E Crowe , Neal Van Hoeven , Larissa B Thackray , Robert H Carnahan

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein.

Nature medicine

Avec: Seth J Zost , Pavlo Gilchuk , Rita E Chen , James Brett Case , Joseph X Reidy , Andrew Trivette , Rachel S Nargi , Rachel E Sutton , Naveenchandra Suryadevara , Elaine C Chen , Elad Binshtein , Swathi Shrihari , Mario Ostrowski , Helen Y Chu , Jonathan E Didier , Keith W MacRenaris , Taylor Jones , Samuel Day , Luke Myers , F Eun-Hyung Lee , Doan C Nguyen , Ignacio Sanz , David R Martinez , Paul W Rothlauf , Louis-Marie Bloyet , Sean P J Whelan , Ralph S Baric , Larissa B Thackray , Michael S Diamond , Robert H Carnahan , James E Crowe

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.

Nature medicine

Avec: Rita E Chen , Xianwen Zhang , James Brett Case , Emma S Winkler , Yang Liu , Laura A VanBlargan , Jianying Liu , John M Errico , Xuping Xie , Naveenchandra Suryadevara , Pavlo Gilchuk , Seth J Zost , Stephen Tahan , Lindsay Droit , Jackson S Turner , Wooseob Kim , Aaron J Schmitz , Mahima Thapa , David Wang , Adrianus C M Boon , Rachel M Presti , Jane A O'Halloran , Alfred H J Kim , Parakkal Deepak , Dora Pinto , Daved H Fremont , James E Crowe , Davide Corti , Herbert W Virgin , Ali H Ellebedy , Pei-Yong Shi , Michael S Diamond

In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains.

Research square

Avec: Michael Diamond , Rita Chen , Emma Winkler , James Case , Ishmael Aziati , Traci Bricker , Astha Joshi , Tamarand Darling , Baoling Ying , John Errico , Swathi Shrihari , Laura VanBlargan , Xuping Xie , Pavlo Gilchuk , Seth Zost , Lindsay Droit , Zhuoming Liu , Spencer Stumpf , David Wang , Scott Handley , W Stine , Pei-Yong Shi , Miguel Garcia-Knight , Raul Andino , Charles Chiu , Ali Ellebedy , Daved Fremont , Sean Whelan , James Crowe , Lisa Purcell , Davide Corti , Andrianus Boon

Pan-ebolavirus protective therapy by two multifunctional human antibodies.

Cell

Avec: Pavlo Gilchuk , Charles D Murin , Robert W Cross , Philipp A Ilinykh , Kai Huang , Natalia Kuzmina , Viktoriya Borisevich , Krystle N Agans , Joan B Geisbert , Seth J Zost , Rachel S Nargi , Rachel E Sutton , Naveenchandra Suryadevara , Robin G Bombardi , Robert H Carnahan , Alexander Bukreyev , Thomas W Geisbert , Andrew B Ward , James E Crowe

Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface.

The Journal of clinical investigation

Avec: Seth J Zost , Jinhui Dong , Iuliia M Gilchuk , Pavlo Gilchuk , Natalie J Thornburg , Sandhya Bangaru , Nurgun Kose , Jessica A Finn , Robin Bombardi , Cinque Soto , Elaine C Chen , Rachel S Nargi , Rachel E Sutton , Ryan P Irving , Naveenchandra Suryadevara , Jonna B Westover , Robert H Carnahan , Hannah L Turner , Sheng Li , Andrew B Ward , James E Crowe

A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection.

Cell reports. Medicine

Avec: Lucas J Adams , Laura A VanBlargan , Zhuoming Liu , Pavlo Gilchuk , Haiyan Zhao , Rita E Chen , Saravanan Raju , Zhenlu Chong , Bradley M Whitener , Swathi Shrihari , Prashant N Jethva , Michael L Gross , James E Crowe , Sean P J Whelan , Michael S Diamond , Daved H Fremont

Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice.

Cell host & microbe

Avec: Iuliia M Gilchuk , Sandhya Bangaru , Pavlo Gilchuk , Ryan P Irving , Nurgun Kose , Robin G Bombardi , Natalie J Thornburg , C Buddy Creech , Kathryn M Edwards , Sheng Li , Hannah L Turner , Wenli Yu , Xueyong Zhu , Ian A Wilson , Andrew B Ward , James E Crowe

High frequency of shared clonotypes in human B cell receptor repertoires.

Nature

Avec: Cinque Soto , Robin G Bombardi , Andre Branchizio , Nurgun Kose , Pranathi Matta , Alexander M Sevy , Robert S Sinkovits , Pavlo Gilchuk , Jessica A Finn , James E Crowe

A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface.

Cell

Avec: Sandhya Bangaru , Shanshan Lang , Michael Schotsaert , Hillary A Vanderven , Xueyong Zhu , Nurgun Kose , Robin Bombardi , Jessica A Finn , Stephen J Kent , Pavlo Gilchuk , Iuliia Gilchuk , Hannah L Turner , Adolfo García-Sastre , Sheng Li , Andrew B Ward , Ian A Wilson , James E Crowe

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope.

Immunity

Avec: Laura A VanBlargan , Lucas J Adams , Zhuoming Liu , Rita E Chen , Pavlo Gilchuk , Saravanan Raju , Brittany K Smith , Haiyan Zhao , James Brett Case , Emma S Winkler , Bradley M Whitener , Lindsay Droit , Ishmael D Aziati , Traci L Bricker , Astha Joshi , Pei-Yong Shi , Adrian Creanga , Amarendra Pegu , Scott A Handley , David Wang , Adrianus C M Boon , James E Crowe , Sean P J Whelan , Daved H Fremont , Michael S Diamond

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein.

Cell

Avec: Naveenchandra Suryadevara , Swathi Shrihari , Pavlo Gilchuk , Laura A VanBlargan , Elad Binshtein , Seth J Zost , Rachel S Nargi , Rachel E Sutton , Emma S Winkler , Elaine C Chen , Mallorie E Fouch , Edgar Davidson , Benjamin J Doranz , Rita E Chen , Pei-Yong Shi , Robert H Carnahan , Larissa B Thackray , Michael S Diamond , James E Crowe

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions and monocytes for optimal therapeutic protection.

bioRxiv : the preprint server for biology

Avec: Emma S Winkler , Pavlo Gilchuk , Jinsheng Yu , Adam L Bailey , Rita E Chen , Seth J Zost , Hyesun Jang , Ying Huang , James D Allen , James Brett Case , Rachel E Sutton , Robert H Carnahan , Tamarand L Darling , Adrianus C M Boon , Matthias Mack , Richard D Head , Ted M Ross , James E Crowe , Michael S Diamond

SARS-CoV-2 variants show resistance to neutralization by many monoclonal and serum-derived polyclonal antibodies.

Research square

Avec: Michael Diamond , Rita Chen , Xuping Xie , James Case , Xianwen Zhang , Laura VanBlargan , Yang Liu , Jianying Liu , John Errico , Emma Winkler , Naveenchandra Suryadevara , Stephen Tahan , Jackson Turner , Wooseob Kim , Aaron Schmitz , Mahima Thapa , David Wang , Andrianus Boon , Dora Pinto , Rachel Presti , Jane O'Halloran , Alfred Kim , Parakkal Deepak , Daved Fremont , Davide Corti , Herbert Virgin , James Crowe , Lindsay Droit , Ali Ellebedy , Pei-Yong Shi , Pavlo Gilchuk

A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques.

Med (New York, N.Y.)

Avec: Ronald R Cobb , Joseph Nkolola , Pavlo Gilchuk , Abishek Chandrashekar , Jingyou Yu , Robert V House , Christopher G Earnhart , Nicole M Dorsey , Svetlana A Hopkins , Doris M Snow , Rita E Chen , Laura A VanBlargan , Manuel Hechenblaickner , Brian Hoppe , Laura Collins , Milan T Tomic , Genevieve H Nonet , Kyal Hackett , James C Slaughter , Mark G Lewis , Hanne Andersen , Anthony Cook , Michael S Diamond , Robert H Carnahan , Dan H Barouch , James E Crowe

Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development.

Frontiers in immunology

Avec: Charles D Murin , Pavlo Gilchuk , James E Crowe , Andrew B Ward

Potently neutralizing and protective human antibodies against SARS-CoV-2.

Nature

Avec: Seth J Zost , Pavlo Gilchuk , James Brett Case , Elad Binshtein , Rita E Chen , Joseph P Nkolola , Alexandra Schäfer , Joseph X Reidy , Andrew Trivette , Rachel S Nargi , Rachel E Sutton , Naveenchandra Suryadevara , David R Martinez , Lauren E Williamson , Elaine C Chen , Taylor Jones , Samuel Day , Luke Myers , Ahmed O Hassan , Natasha M Kafai , Emma S Winkler , Julie M Fox , Swathi Shrihari , Benjamin K Mueller , Jens Meiler , Abishek Chandrashekar , Noe B Mercado , James J Steinhardt , Kuishu Ren , Yueh-Ming Loo , Nicole L Kallewaard , Broc T McCune , Shamus P Keeler , Michael J Holtzman , Dan H Barouch , Lisa E Gralinski , Ralph S Baric , Larissa B Thackray , Michael S Diamond , Robert H Carnahan , James E Crowe

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals.

bioRxiv : the preprint server for biology

Avec: Seth J Zost , Pavlo Gilchuk , James Brett Case , Elad Binshtein , Rita E Chen , Joseph X Reidy , Andrew Trivette , Rachel S Nargi , Rachel E Sutton , Naveenchandra Suryadevara , Lauren E Williamson , Elaine C Chen , Taylor Jones , Samuel Day , Luke Myers , Ahmed O Hassan , Natasha M Kafai , Emma S Winkler , Julie M Fox , James J Steinhardt , Kuishu Ren , Yueh-Ming Loo , Nicole L Kallewaard , David R Martinez , Alexandra Schäfer , Lisa E Gralinski , Ralph S Baric , Larissa B Thackray , Michael S Diamond , Robert H Carnahan , James E Crowe

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein.

bioRxiv : the preprint server for biology

Avec: Seth J Zost , Pavlo Gilchuk , Rita E Chen , James Brett Case , Joseph X Reidy , Andrew Trivette , Rachel S Nargi , Rachel E Sutton , Naveenchandra Suryadevara , Elaine C Chen , Elad Binshtein , Swathi Shrihari , Mario Ostrowski , Helen Y Chu , Jonathan E Didier , Keith W MacRenaris , Taylor Jones , Samuel Day , Luke Myers , F Eun-Hyung Lee , Doan C Nguyen , Ignacio Sanz , David R Martinez , Ralph S Baric , Larissa B Thackray , Michael S Diamond , Robert H Carnahan , James E Crowe

Antibody-Mediated Protective Mechanisms Induced by a Trivalent Parainfluenza Virus-Vectored Ebolavirus Vaccine.

Journal of virology

Avec: J Brian Kimble , Delphine C Malherbe , Michelle Meyer , Bronwyn M Gunn , Marcus M Karim , Philipp A Ilinykh , Mathieu Iampietro , Khaled S Mohamed , Surendra Negi , Pavlo Gilchuk , Kai Huang , Yuri I Wolf , Werner Braun , James E Crowe , Galit Alter , Alexander Bukreyev

Standardized two-step testing of antibody activity in COVID-19 convalescent plasma.

iScience

Avec: Pavlo Gilchuk , Isaac Thomsen , Sandra Yoder , Eric Brady , James D Chappell , Laura J Stevens , Mark R Denison , Rachel E Sutton , Rita E Chen , Laura A VanBlargan , Naveenchandra Suryadevara , Seth J Zost , Jonathan Schmitz , Jill M Pulley , Michael S Diamond , Jillian P Rhoads , Gordon R Bernard , Wesley H Self , Todd W Rice , Allison P Wheeler , James E Crowe , Robert H Carnahan

A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope.

bioRxiv : the preprint server for biology

Avec: Laura VanBlargan , Lucas Adams , Zhuoming Liu , Rita E Chen , Pavlo Gilchuk , Saravanan Raju , Brittany Smith , Haiyan Zhao , James Brett Case , Emma S Winkler , Bradley Whitener , Lindsay Droit , Ismael Aziati , Pei-Yong Shi , Adrian Creanga , Amarendra Pegu , Scott Handley , David Wang , Adrianus Boon , James E Crowe , Sean P J Whelan , Daved Fremont , Michael Diamond

Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Nina G Bozhanova , Amandeep K Sangha , Alexander M Sevy , Pavlo Gilchuk , Kai Huang , Rachel S Nargi , Joseph X Reidy , Andrew Trivette , Robert H Carnahan , Alexander Bukreyev , James E Crowe , Jens Meiler

Real-time cell analysis: A high-throughput approach for testing SARS-CoV-2 antibody neutralization and escape.

STAR protocols

Avec: Naveenchandra Suryadevara , Pavlo Gilchuk , Seth J Zost , Nikhil Mittal , Li Leyna Zhao , James E Crowe , Robert H Carnahan

Antiviral protection by antibodies targeting the glycan cap of Ebola virus glycoprotein requires activation of the complement system.

Research square

Avec: Alexander Bukreyev , Philipp Ilinykh , Kai Huang , Bronwyn Gunn , Natalia Kuzmina , Pavlo Gilchuk , Galit Alter , James Crowe

Mucosal Immunization with a pH-Responsive Nanoparticle Vaccine Induces Protective CD8

ACS nano

Avec: Frances C Knight , Pavlo Gilchuk , Amrendra Kumar , Kyle W Becker , Sema Sevimli , Max E Jacobson , Naveenchandra Suryadevara , Lihong Wang-Bishop , Kelli L Boyd , James E Crowe , Sebastian Joyce , John T Wilson

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.

Immunity

Avec: Pavlo Gilchuk , Charles D Murin , Jacob C Milligan , Robert W Cross , Chad E Mire , Philipp A Ilinykh , Kai Huang , Natalia Kuzmina , Pilar X Altman , Sean Hui , Bronwyn M Gunn , Aubrey L Bryan , Edgar Davidson , Benjamin J Doranz , Hannah L Turner , Tanwee Alkutkar , Robin Flinko , Chiara Orlandi , Robert Carnahan , Rachel Nargi , Robin G Bombardi , Megan E Vodzak , Sheng Li , Adaora Okoli , Morris Ibeawuchi , Benjamin Ohiaeri , George K Lewis , Galit Alter , Alexander Bukreyev , Erica Ollmann Saphire , Thomas W Geisbert , Andrew B Ward , James E Crowe

Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies.

Cell host & microbe

Avec: Philipp A Ilinykh , Kai Huang , Rodrigo I Santos , Pavlo Gilchuk , Bronwyn M Gunn , Marcus M Karim , Jenny Liang , Mallorie E Fouch , Edgar Davidson , Diptiben V Parekh , James B Kimble , Colette A Pietzsch , Michelle Meyer , Natalia A Kuzmina , Larry Zeitlin , Erica Ollmann Saphire , Galit Alter , James E Crowe , Alexander Bukreyev

In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains.

Nature

Avec: Rita E Chen , Emma S Winkler , James Brett Case , Ishmael D Aziati , Traci L Bricker , Astha Joshi , Tamarand L Darling , Baoling Ying , John M Errico , Swathi Shrihari , Laura A VanBlargan , Xuping Xie , Pavlo Gilchuk , Seth J Zost , Lindsay Droit , Zhuoming Liu , Spencer Stumpf , David Wang , Scott A Handley , W Blaine Stine , Pei-Yong Shi , Meredith E Davis-Gardner , Mehul S Suthar , Miguel Garcia Knight , Raul Andino , Charles Y Chiu , Ali H Ellebedy , Daved H Fremont , Sean P J Whelan , James E Crowe , Lisa Purcell , Davide Corti , Adrianus C M Boon , Michael S Diamond

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail.

Nature microbiology

Avec: Jinhui Dong , Seth J Zost , Allison J Greaney , Tyler N Starr , Adam S Dingens , Elaine C Chen , Rita E Chen , James Brett Case , Rachel E Sutton , Pavlo Gilchuk , Jessica Rodriguez , Erica Armstrong , Christopher Gainza , Rachel S Nargi , Elad Binshtein , Xuping Xie , Xianwen Zhang , Pei-Yong Shi , James Logue , Stuart Weston , Marisa E McGrath , Matthew B Frieman , Tyler Brady , Kevin M Tuffy , Helen Bright , Yueh-Ming Loo , Patrick M McTamney , Mark T Esser , Robert H Carnahan , Michael S Diamond , Jesse D Bloom , James E Crowe

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition.

Cell host & microbe

Avec: Allison J Greaney , Tyler N Starr , Pavlo Gilchuk , Seth J Zost , Elad Binshtein , Andrea N Loes , Sarah K Hilton , John Huddleston , Rachel Eguia , Katharine H D Crawford , Adam S Dingens , Rachel S Nargi , Rachel E Sutton , Naveenchandra Suryadevara , Paul W Rothlauf , Zhuoming Liu , Sean P J Whelan , Robert H Carnahan , James E Crowe , Jesse D Bloom

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals.

bioRxiv : the preprint server for biology

Avec: Elaine C Chen , Pavlo Gilchuk , Seth J Zost , Naveenchandra Suryadevara , Emma S Winkler , Carly R Cabel , Elad Binshtein , Rachel E Sutton , Jessica Rodriguez , Samuel Day , Luke Myers , Andrew Trivette , Jazmean K Williams , Edgar Davidson , Shuaizhi Li , Benjamin J Doranz , Samuel K Campos , Robert H Carnahan , Curtis A Thorne , Michael S Diamond , James E Crowe

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection.

Cell

Avec: Emma S Winkler , Pavlo Gilchuk , Jinsheng Yu , Adam L Bailey , Rita E Chen , Zhenlu Chong , Seth J Zost , Hyesun Jang , Ying Huang , James D Allen , James Brett Case , Rachel E Sutton , Robert H Carnahan , Tamarand L Darling , Adrianus C M Boon , Matthias Mack , Richard D Head , Ted M Ross , James E Crowe , Michael S Diamond

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail.

bioRxiv : the preprint server for biology

Avec: Jinhui Dong , Seth Zost , Allison Greaney , Tyler N Starr , Adam S Dingens , Elaine C Chen , Rita Chen , Brett Case , Rachel Sutton , Pavlo Gilchuk , Jessica Rodriguez , Erica Armstrong , Christopher Gainza , Rachel Nargi , Elad Binshtein , Xuping Xie , Xianwen Zhang , Pei-Yong Shi , James Logue , Stuart Weston , Marisa McGrath , Matthew Frieman , Tyler Brady , Kevin Tuffy , Helen Bright , Yueh-Ming Loo , Patrick McvTamney , Mark Esser , Robert Carnahan , Michael Diamond , Jesse Bloom , James E Crowe

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein.

bioRxiv : the preprint server for biology

Avec: Naveenchandra Suryadevara , Swathi Shrihari , Pavlo Gilchuk , Laura A VanBlargan , Elad Binshtein , Seth J Zost , Rachel S Nargi , Rachel E Sutton , Emma S Winkler , Elaine C Chen , Mallorie E Fouch , Edgar Davidson , Benjamin J Doranz , Robert H Carnahan , Larissa B Thackray , Michael S Diamond , James E Crowe

Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition.

bioRxiv : the preprint server for biology

Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma.

Frontiers in immunology

Avec: Pavlo Gilchuk , Adrian Guthals , Stefano R Bonissone , Jared B Shaw , Philipp A Ilinykh , Kai Huang , Robin G Bombardi , Jenny Liang , Ariadna Grinyo , Edgar Davidson , Elaine C Chen , Bronwyn M Gunn , Galit Alter , Erica Ollmann Saphire , Benjamin J Doranz , Alexander Bukreyev , Larry Zeitlin , Natalie Castellana , James E Crowe

Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized With COVID-19: A Blinded, Randomized, Placebo-Controlled Trial.

Chest

Avec: Wesley H Self , Allison P Wheeler , Thomas G Stewart , Harry Schrager , Jason Mallada , Christopher B Thomas , Vince D Cataldo , Hollis R O'Neal , Nathan I Shapiro , Conor Higgins , Adit A Ginde , Lakshmi Chauhan , Nicholas J Johnson , Daniel J Henning , Stuti J Jaiswal , Manoj J Mammen , Estelle S Harris , Sonal R Pannu , Maryrose Laguio-Vila , Wissam El Atrouni , Marjolein de Wit , Daanish Hoda , Claudia S Cohn , Carla McWilliams , Carl Shanholtz , Alan E Jones , Jay S Raval , Simon Mucha , Tina S Ipe , Xian Qiao , Stephen J Schrantz , Aarthi Shenoy , Richard D Fremont , Eric J Brady , Robert H Carnahan , James D Chappell , James E Crowe , Mark R Denison , Pavlo Gilchuk , Laura J Stevens , Rachel E Sutton , Isaac Thomsen , Sandra M Yoder , Amanda J Bistran-Hall , Jonathan D Casey , Christopher J Lindsell , Li Wang , Jill M Pulley , Jillian P Rhoads , Gordon R Bernard , Todd W Rice , Auteur inconnu

Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes.

Cell reports

Avec: Elaine C Chen , Pavlo Gilchuk , Seth J Zost , Philipp A Ilinykh , Elad Binshtein , Kai Huang , Luke Myers , Stefano Bonissone , Samuel Day , Chandrahaas R Kona , Andrew Trivette , Joseph X Reidy , Rachel E Sutton , Christopher Gainza , Summer Diaz , Jazmean K Williams , Christopher N Selverian , Edgar Davidson , Erica Ollmann Saphire , Benjamin J Doranz , Natalie Castellana , Alexander Bukreyev , Robert H Carnahan , James E Crowe

Réseau de co-auteurs

James E Crowe 42 collaborations

Robert H Carnahan 23 collaborations

Seth J Zost 20 collaborations

Michael S Diamond 19 collaborations

Rachel E Sutton 18 collaborations

Naveenchandra Suryadevara 17 collaborations

Rita E Chen 16 collaborations

Elad Binshtein 14 collaborations

Elaine C Chen 13 collaborations

Alexander Bukreyev 12 collaborations

Emma S Winkler 12 collaborations

Rachel S Nargi 12 collaborations

Kai Huang 11 collaborations

James Brett Case 11 collaborations

Edgar Davidson 10 collaborations

Philipp A Ilinykh 9 collaborations

Benjamin J Doranz 9 collaborations

Laura A VanBlargan 9 collaborations

Pei-Yong Shi 9 collaborations

Zhuoming Liu 8 collaborations

Sean P J Whelan 8 collaborations

Andrew Trivette 8 collaborations

Swathi Shrihari 8 collaborations

Andrew B Ward 7 collaborations

Samuel Day 7 collaborations

Luke Myers 7 collaborations

Galit Alter 7 collaborations

Larissa B Thackray 7 collaborations

Robin G Bombardi 6 collaborations

Joseph X Reidy 6 collaborations

Xuping Xie 6 collaborations

Lindsay Droit 6 collaborations

David Wang 6 collaborations

Natalia Kuzmina 5 collaborations

Lauren E Williamson 5 collaborations

Erica Ollmann Saphire 5 collaborations

Jessica Rodriguez 5 collaborations

Bronwyn M Gunn 5 collaborations

Taylor Jones 5 collaborations

Adrianus C M Boon 5 collaborations

Charles D Murin 4 collaborations

Paul W Rothlauf 4 collaborations

Jinhui Dong 4 collaborations

Rachel Nargi 4 collaborations

Mallorie E Fouch 4 collaborations

David R Martinez 4 collaborations

Ralph S Baric 4 collaborations

Xianwen Zhang 4 collaborations

Daved H Fremont 4 collaborations

Davide Corti 4 collaborations

Michael Diamond 4 collaborations

Nurgun Kose 4 collaborations

Hannah L Turner 4 collaborations

Sheng Li 4 collaborations

Yueh-Ming Loo 4 collaborations

Tyler N Starr 4 collaborations

Adam S Dingens 4 collaborations

Robin Bombardi 3 collaborations

Adam L Bailey 3 collaborations

Jazmean K Williams 3 collaborations

Erica Armstrong 3 collaborations

Jens Meiler 3 collaborations

Cinque Soto 3 collaborations

Jenny Liang 3 collaborations

Dan H Barouch 3 collaborations

Rita Chen 3 collaborations

Astha Joshi 3 collaborations

Laura VanBlargan 3 collaborations

Daved Fremont 3 collaborations

James Crowe 3 collaborations

Sandhya Bangaru 3 collaborations

Jessica A Finn 3 collaborations

Haiyan Zhao 3 collaborations

Saravanan Raju 3 collaborations

Tamarand L Darling 3 collaborations

Allison J Greaney 3 collaborations

Christopher Gainza 3 collaborations

Jesse D Bloom 3 collaborations

Aubrey L Bryan 2 collaborations

Tanwee Alkutkar 2 collaborations

Sean Hui 2 collaborations

Carly R Cabel 2 collaborations

Shuaizhi Li 2 collaborations

Samuel K Campos 2 collaborations

Curtis A Thorne 2 collaborations

Amandeep K Sangha 2 collaborations

Delphine C Malherbe 2 collaborations

Rachel Sutton 2 collaborations

Natalia A Kuzmina 2 collaborations

Joseph Nkolola 2 collaborations

Mario Ostrowski 2 collaborations

Helen Y Chu 2 collaborations

Jonathan E Didier 2 collaborations

Keith W MacRenaris 2 collaborations

F Eun-Hyung Lee 2 collaborations

Doan C Nguyen 2 collaborations

Ignacio Sanz 2 collaborations

Yang Liu 2 collaborations

Jianying Liu 2 collaborations

John M Errico 2 collaborations

Stephen Tahan 2 collaborations

Wooseob Kim 2 collaborations

Mahima Thapa 2 collaborations

Parakkal Deepak 2 collaborations

Dora Pinto 2 collaborations

Ali H Ellebedy 2 collaborations

Emma Winkler 2 collaborations

James Case 2 collaborations

Baoling Ying 2 collaborations

John Errico 2 collaborations

Seth Zost 2 collaborations

Spencer Stumpf 2 collaborations

Scott Handley 2 collaborations

Raul Andino 2 collaborations

Ali Ellebedy 2 collaborations

Lisa Purcell 2 collaborations

Andrianus Boon 2 collaborations

Robert W Cross 2 collaborations

Thomas W Geisbert 2 collaborations

Iuliia M Gilchuk 2 collaborations

Natalie J Thornburg 2 collaborations

Ryan P Irving 2 collaborations

Lucas J Adams 2 collaborations

Zhenlu Chong 2 collaborations

Bradley M Whitener 2 collaborations

Xueyong Zhu 2 collaborations

Ian A Wilson 2 collaborations

Alexander M Sevy 2 collaborations

Ishmael D Aziati 2 collaborations

Traci L Bricker 2 collaborations

Adrian Creanga 2 collaborations

Amarendra Pegu 2 collaborations

Scott A Handley 2 collaborations

Jinsheng Yu 2 collaborations

Hyesun Jang 2 collaborations

Ying Huang 2 collaborations

James D Allen 2 collaborations

Matthias Mack 2 collaborations

Richard D Head 2 collaborations

Ted M Ross 2 collaborations

Abishek Chandrashekar 2 collaborations

Alexandra Schäfer 2 collaborations

Ahmed O Hassan 2 collaborations

Natasha M Kafai 2 collaborations

Julie M Fox 2 collaborations

James J Steinhardt 2 collaborations

Kuishu Ren 2 collaborations

Nicole L Kallewaard 2 collaborations

Lisa E Gralinski 2 collaborations

Michelle Meyer 2 collaborations

Marcus M Karim 2 collaborations

Isaac Thomsen 2 collaborations

James D Chappell 2 collaborations

Laura J Stevens 2 collaborations

Mark R Denison 2 collaborations

Jill M Pulley 2 collaborations

Jillian P Rhoads 2 collaborations

Gordon R Bernard 2 collaborations

Wesley H Self 2 collaborations

Todd W Rice 2 collaborations

Allison P Wheeler 2 collaborations

Robert Carnahan 2 collaborations

Larry Zeitlin 2 collaborations

James Logue 2 collaborations

Stuart Weston 2 collaborations

Tyler Brady 2 collaborations

Helen Bright 2 collaborations

Andrea N Loes 2 collaborations

Sarah K Hilton 2 collaborations

John Huddleston 2 collaborations

Rachel Eguia 2 collaborations

Katharine H D Crawford 2 collaborations

Natalie Castellana 2 collaborations

Xiaoli Shen 1 collaboration

Jessica F Bruhn 1 collaboration

Jeffrey Copps 1 collaboration

Andrew I Flyak 1 collaboration

Liam B King 1 collaboration

Brandyn R West 1 collaboration

Crystal L Moyer 1 collaboration

Andrew Flyak 1 collaboration

Maritza Puray-Chavez 1 collaboration

Kyle M LaPak 1 collaboration

Travis P Schrank 1 collaboration

Jennifer L Elliott 1 collaboration

Dhaval P Bhatt 1 collaboration

Megan J Agajanian 1 collaboration

Ria Jasuja 1 collaboration

Dana Q Lawson 1 collaboration

Keanu Davis 1 collaboration

Heejoon Jo 1 collaboration

Nakyung Lee 1 collaboration

Kasyap Tenneti 1 collaboration

Jenna E Eschbach 1 collaboration

Christian Shema Mugisha 1 collaboration

Emily M Cousins 1 collaboration

Erica W Cloer 1 collaboration

Hung R Vuong 1 collaboration

D Neil Hayes 1 collaboration

Amjad Horani 1 collaboration

Steven L Brody 1 collaboration

Dennis Goldfarb 1 collaboration

M Ben Major 1 collaboration

Sebla B Kutluay 1 collaboration

Clara T Schoeder 1 collaboration

Kaitlyn V Ledwitch 1 collaboration

Xuan Zhang 1 collaboration

Cristina E Martina 1 collaboration

Brooke Fiala 1 collaboration

Neil P King 1 collaboration

Kritika Kedarinath 1 collaboration

Eduardo Jurado-Cobena 1 collaboration

Fuchun Zhou 1 collaboration

Chandru Subramani 1 collaboration

Matthew A Hyde 1 collaboration

Jalene V Velazquez 1 collaboration

Jesse H Erasmus 1 collaboration

Qing Tan 1 collaboration

Peter Abbink 1 collaboration

Todd J Suscovich 1 collaboration

Lorellin A Durnell 1 collaboration

Amit Khandhar 1 collaboration

Jacob Archer 1 collaboration

Elise Larson 1 collaboration

Stacey Ertel 1 collaboration

Brian Granger 1 collaboration

Jasmine Fuerte-Stone 1 collaboration

Vicky Roy 1 collaboration

Thomas Broge 1 collaboration

Thomas C Linnekin 1 collaboration

Caitlyn H Linde 1 collaboration

Matthew J Gorman 1 collaboration

Steven G Reed 1 collaboration

Neal Van Hoeven 1 collaboration

Louis-Marie Bloyet 1 collaboration

Jackson S Turner 1 collaboration

Aaron J Schmitz 1 collaboration

Rachel M Presti 1 collaboration

Jane A O'Halloran 1 collaboration

Alfred H J Kim 1 collaboration

Herbert W Virgin 1 collaboration

Ishmael Aziati 1 collaboration

Traci Bricker 1 collaboration

Tamarand Darling 1 collaboration

W Stine 1 collaboration

Miguel Garcia-Knight 1 collaboration

Charles Chiu 1 collaboration

Sean Whelan 1 collaboration

Viktoriya Borisevich 1 collaboration

Krystle N Agans 1 collaboration

Joan B Geisbert 1 collaboration

Jonna B Westover 1 collaboration

Prashant N Jethva 1 collaboration

Michael L Gross 1 collaboration

C Buddy Creech 1 collaboration

Kathryn M Edwards 1 collaboration

Wenli Yu 1 collaboration

Andre Branchizio 1 collaboration

Pranathi Matta 1 collaboration

Robert S Sinkovits 1 collaboration

Shanshan Lang 1 collaboration

Michael Schotsaert 1 collaboration

Hillary A Vanderven 1 collaboration

Stephen J Kent 1 collaboration

Iuliia Gilchuk 1 collaboration

Adolfo García-Sastre 1 collaboration

Brittany K Smith 1 collaboration

Jackson Turner 1 collaboration

Aaron Schmitz 1 collaboration

Rachel Presti 1 collaboration

Jane O'Halloran 1 collaboration

Alfred Kim 1 collaboration

Herbert Virgin 1 collaboration

Ronald R Cobb 1 collaboration

Jingyou Yu 1 collaboration

Robert V House 1 collaboration

Christopher G Earnhart 1 collaboration

Nicole M Dorsey 1 collaboration

Svetlana A Hopkins 1 collaboration

Doris M Snow 1 collaboration

Manuel Hechenblaickner 1 collaboration

Brian Hoppe 1 collaboration

Laura Collins 1 collaboration

Milan T Tomic 1 collaboration

Genevieve H Nonet 1 collaboration

Kyal Hackett 1 collaboration

James C Slaughter 1 collaboration

Mark G Lewis 1 collaboration

Hanne Andersen 1 collaboration

Anthony Cook 1 collaboration

Joseph P Nkolola 1 collaboration

Benjamin K Mueller 1 collaboration

Noe B Mercado 1 collaboration

Broc T McCune 1 collaboration

Shamus P Keeler 1 collaboration

Michael J Holtzman 1 collaboration

J Brian Kimble 1 collaboration

Mathieu Iampietro 1 collaboration

Khaled S Mohamed 1 collaboration

Surendra Negi 1 collaboration

Yuri I Wolf 1 collaboration

Werner Braun 1 collaboration

Sandra Yoder 1 collaboration

Eric Brady 1 collaboration

Jonathan Schmitz 1 collaboration

Lucas Adams 1 collaboration

Brittany Smith 1 collaboration

Bradley Whitener 1 collaboration

Ismael Aziati 1 collaboration

Adrianus Boon 1 collaboration

Nina G Bozhanova 1 collaboration

Nikhil Mittal 1 collaboration

Li Leyna Zhao 1 collaboration

Philipp Ilinykh 1 collaboration

Bronwyn Gunn 1 collaboration

Frances C Knight 1 collaboration

Amrendra Kumar 1 collaboration

Kyle W Becker 1 collaboration

Sema Sevimli 1 collaboration

Max E Jacobson 1 collaboration

Lihong Wang-Bishop 1 collaboration

Kelli L Boyd 1 collaboration

Sebastian Joyce 1 collaboration

John T Wilson 1 collaboration

Jacob C Milligan 1 collaboration

Chad E Mire 1 collaboration

Pilar X Altman 1 collaboration

Robin Flinko 1 collaboration

Chiara Orlandi 1 collaboration

Megan E Vodzak 1 collaboration

Adaora Okoli 1 collaboration

Morris Ibeawuchi 1 collaboration

Benjamin Ohiaeri 1 collaboration

George K Lewis 1 collaboration

Rodrigo I Santos 1 collaboration

Diptiben V Parekh 1 collaboration

James B Kimble 1 collaboration

Colette A Pietzsch 1 collaboration

W Blaine Stine 1 collaboration

Meredith E Davis-Gardner 1 collaboration

Mehul S Suthar 1 collaboration

Miguel Garcia Knight 1 collaboration

Charles Y Chiu 1 collaboration

Marisa E McGrath 1 collaboration

Matthew B Frieman 1 collaboration

Kevin M Tuffy 1 collaboration

Patrick M McTamney 1 collaboration

Mark T Esser 1 collaboration

Allison Greaney 1 collaboration

Brett Case 1 collaboration

Marisa McGrath 1 collaboration

Matthew Frieman 1 collaboration

Kevin Tuffy 1 collaboration

Patrick McvTamney 1 collaboration

Mark Esser 1 collaboration

Jesse Bloom 1 collaboration

Adrian Guthals 1 collaboration

Stefano R Bonissone 1 collaboration

Jared B Shaw 1 collaboration

Ariadna Grinyo 1 collaboration

Thomas G Stewart 1 collaboration

Harry Schrager 1 collaboration

Jason Mallada 1 collaboration

Christopher B Thomas 1 collaboration

Vince D Cataldo 1 collaboration

Hollis R O'Neal 1 collaboration

Nathan I Shapiro 1 collaboration

Conor Higgins 1 collaboration

Adit A Ginde 1 collaboration

Lakshmi Chauhan 1 collaboration

Nicholas J Johnson 1 collaboration

Daniel J Henning 1 collaboration

Stuti J Jaiswal 1 collaboration

Manoj J Mammen 1 collaboration

Estelle S Harris 1 collaboration

Sonal R Pannu 1 collaboration

Maryrose Laguio-Vila 1 collaboration

Wissam El Atrouni 1 collaboration

Marjolein de Wit 1 collaboration

Daanish Hoda 1 collaboration

Claudia S Cohn 1 collaboration

Carla McWilliams 1 collaboration

Carl Shanholtz 1 collaboration

Alan E Jones 1 collaboration

Jay S Raval 1 collaboration

Simon Mucha 1 collaboration

Tina S Ipe 1 collaboration

Xian Qiao 1 collaboration

Stephen J Schrantz 1 collaboration

Aarthi Shenoy 1 collaboration

Richard D Fremont 1 collaboration

Eric J Brady 1 collaboration

Sandra M Yoder 1 collaboration

Amanda J Bistran-Hall 1 collaboration

Jonathan D Casey 1 collaboration

Christopher J Lindsell 1 collaboration

Li Wang 1 collaboration

None None 1 collaboration

Stefano Bonissone 1 collaboration

Chandrahaas R Kona 1 collaboration

Summer Diaz 1 collaboration

Christopher N Selverian 1 collaboration